Article
Marine & Freshwater Biology
Sara Norgaard Sorensen, Henning Wigger, Alex Zabeo, Elena Semenzin, Danail Hristozov, Bernd Nowack, David J. Spurgeon, Anders Baun
AQUATIC TOXICOLOGY
(2020)
Article
Chemistry, Physical
Elisa Giubilato, Virginia Cazzagon, Monica J. B. Amorim, Magda Blosi, Jacques Bouillard, Hans Bouwmeester, Anna Luisa Costa, Bengt Fadeel, Teresa F. Fernandes, Carlos Fito, Marina Hauser, Antonio Marcomini, Bernd Nowack, Lisa Pizzol, Leagh Powell, Adriele Prina-Mello, Haralambos Sarimveis, Janeck James Scott-Fordsmand, Elena Semenzin, Burkhard Stahlmecke, Vicki Stone, Alexis Vignes, Terry Wilkins, Alex Zabeo, Lang Tran, Danail Hristozov
Article
Chemistry, Multidisciplinary
Vicki Stone, Stefania Gottardo, Eric A. J. Bleeker, Hedwig Braakhuis, Susan Dekkers, Teresa Fernandes, Andrea Haase, Neil Hunt, Danail Hristozov, Paula Jantunen, Nina Jeliazkova, Helinor Johnston, Lara Lamon, Fiona Murphy, Kirsten Rasmussen, Hubert Rauscher, Araceli Sanchez Jimenez, Claus Svendsen, David Spurgeon, Socorro Vazquez-Campos, Wendel Wohlleben, Agnes G. Oomen
Article
Environmental Sciences
Nina Jeliazkova, Eric Bleeker, Richard Cross, Andrea Haase, Gemma Janer, Willie Peijnenburg, Mario Pink, Hubert Rauscher, Claus Svendsen, Georgia Tsiliki, Alex Zabeo, Danail Hristozov, Vicki Stone, Wendel Wohlleben
Summary: This paper discusses methods for grouping nanoforms and evaluating data similarity, emphasizing the property-by-property evaluation of the data matrix to support grouping. Multidimensional approaches were found to offer unexpected insights from a scientific perspective, but were deemed difficult to use in a regulatory context.
Article
Environmental Sciences
V. Cazzagon, E. Giubilato, L. Pizzol, C. Ravagli, S. Doumett, G. Baldi, M. Blosi, A. Brunelli, C. Fito, F. Huertas, A. Marcomini, E. Semenzin, A. Zabeo, I. Zanoni, D. Hristozov
Summary: The safety assessment of nano-biomedical products is crucial for market authorization and must consider the safety of workers and medical professionals. Limited workplace risk assessments exist for NBMs in medical applications, but using a software-based Decision Support System can help increase knowledge in this area.
Article
Environmental Sciences
Alex Zabeo, Gianpietro Basei, Georgia Tsiliki, Willie Peijnenburg, Danail Hristozov
Summary: The proposed novel procedure for similarity assessment and grouping of nanomaterials is based on various metrics and hierarchical clustering, ensuring robust grouping independent of the dataset used, and a software tool has been developed to facilitate its application.
Article
Environmental Sciences
Gianpietro Basei, Alex Zabeo, Kirsten Rasmussen, Georgia Tsiliki, Danail Hristozov
Summary: The study proposes a quantitative Weight of Evidence (WoE) approach for hazard classification of nanomaterials, integrating and evaluating results from heterogeneous studies based on data quality and completeness criteria, with the ability to highlight uncertainty through probabilistic integration. The use of Monte Carlo resampling allows for the quantitative integration of weighted evidence, leading to coherent and justifiable hazard classification of nanomaterials.
Article
Environmental Sciences
Georgia Tsiliki, Didem Ag Seleci, Alex Zabeo, Gianpietro Basei, Danail Hristozov, Nina Jeliazkova, Matthew Boyles, Fiona Murphy, Willie Peijnenburg, Wendel Wohlleben, Vicki Stone
Summary: The article presents a novel computational method for comparing dose-response curves of nanoforms and identifying similar nanoforms for toxicity grouping research.
Article
Nanoscience & Nanotechnology
Gianpietro Basei, Hubert Rauscher, Nina Jeliazkova, Danail Hristozov
Summary: This manuscript proposes a methodology to assess the completeness and quality of physicochemical and hazard datasets for risk assessment purposes. The unique goal of this approach is to assess data quality in such a way that all the steps are automatized, thus reducing reliance on expert judgment.
Article
Green & Sustainable Science & Technology
Stella Stoycheva, Alex Zabeo, Lisa Pizzol, Danail Hristozov
Summary: This manuscript presents an innovative approach to socio-economic assessment of advanced engineered nanomaterials and nano-enabled products to support safe-and-sustainable-by-design decision-making by industries. The methodology combines social life cycle analysis and multi-criteria decision analysis methods to assess socio-economic impacts over the full life cycle of a product. A user-friendly Excel-based self-assessment tool was developed to facilitate its application by industries.
Article
Instruments & Instrumentation
Alex Zabeo, Fabio Rosada, Lisa Pizzol, Fanny Caputo, Sven Even Borgos, Jeremie Parot, Robert E. Geertsma, Joost Jacob Pouw, Rob J. Vandebriel, Oihane Ibarrola Moreno, Danail Hristozov
Summary: The application of nanomaterials in medicine has great potential, but the translation of these technologies to clinical practice faces challenges. To support the development and clinical implementation of nanotechnology-enabled health products, the REFINE project has developed a Decision Support System (DSS) to assist developers in preclinical assessment and intelligent testing, improving efficiency.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
L. G. Powell, S. Gillies, T. F. Fernandes, F. Murphy, E. Giubilato, V. Cazzagon, D. Hristozov, L. Pizzol, M. Blosi, A. L. Costa, A. Prina-Mello, H. Bouwmeester, H. Sarimveis, G. Janer, V. Stone
Summary: This article provides guidance for implementing tailored safety assessment strategies for nanomaterials in order to increase their translation from bench development to clinical use. Integrated Approaches to Testing and Assessment (IATAs) are key tools in developing these strategies.
Article
Biotechnology & Applied Microbiology
V. Cazzagon, E. Giubilato, A. Bonetto, M. Blosi, I. Zanoni, A. L. Costa, C. Vineis, A. Varesano, A. Marcomini, D. Hristozov, E. Semenzin, E. Badetti
Summary: The use of silver nanoparticles in medical devices is increasing due to their antimicrobial properties. A Safe-by-Design procedure has been developed to reduce environmental risks and optimize wound dressings containing silver nanoparticles. By comparing with existing products on the market, the procedure proved to be effective in selecting the best alternative.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristo, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Summary: Manufacturing and functionalizing materials at the nanoscale has led to the generation of various nanoforms of substances. Testing every unique nanoform for adverse effects is impossible, thus hypothesis-driven grouping and read-across approaches supported by the GRACIOUS Framework are promising alternatives for efficient risk assessment. The framework enables the assessment of similarity between nanoforms, minimizing the need for new testing and aligning with the 3R principles. The template used to generate GRACIOUS grouping hypotheses and the IATAs provide a structured approach for data gathering, facilitating decision-making.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2023)
