Article
Multidisciplinary Sciences
Boris Barbarics, Katja Eildermann, Lars Kaderali, Lukas Cyganek, Uwe Plessmann, Julius Bodemeyer, Thomas Paul, Philipp Stroebel, Henning Urlaub, Theodorus Tirilomis, Christof Lenz, Hanibal Bohnenberger
Summary: Aortic valve stenosis (AVS) is a common valve disease, but biological understanding of myocardial changes at the proteome level is still lacking. This study used high-resolution mass spectrometry to analyze FFPE human myocardial tissue samples from AVS patients, revealing significant upregulation and downregulation of multiple proteins associated with AVS-related changes such as cardiac hypertrophy, fibrosis, impaired mitochondria, and reduced blood supply. The findings provide a workflow for quantitative proteomics of human FFPE heart tissue and a comprehensive proteomic resource for AVS induced changes in the human myocardium.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Andrew R. Kompa, Fay L. Khong, Yuan Zhang, Cindy Nguyen, Amanda J. Edgley, Owen L. Woodman, Grant McLachlan, Darren J. Kelly
Summary: This study evaluated the efficacy of NP202, a synthetic flavonol, on cardiac remodelling in a chronic model of myocardial infarction (MI). Results showed that NP202 improved left ventricular function and structure, especially at a higher dose. NP202 also reduced hypertrophy and interstitial fibrosis in the non-infarct region of the myocardium.
Article
Biochemistry & Molecular Biology
Tilo Thottakara, Natalie Lund, Elisabeth Kraemer, Paulus Kirchhof, Lucie Carrier, Monica Patten
Summary: Circulating levels of miR-1, miR-495-3p, and miR-4454 are elevated in the plasma of HCM patients, with a significant correlation between miR-4454 levels and cardiac fibrosis. This suggests miR-4454 as a potential biomarker for fibrosis in these patients.
Article
Biochemistry & Molecular Biology
Maryam Farazandeh, Maryam Mahmoudabady, Ali Akbar Asghari, Saeed Niazmand
Summary: Cinnamon extract can prevent diabetic heart damage by alleviating cardiac inflammation and fibrosis, in addition to its hypoglycemic and antioxidant properties.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Cell Biology
Matthew Amoni, Eef Dries, Sebastian Ingelaere, Dylan Vermoortele, H. Llewelyn Roderick, Piet Claus, Rik Willems, Karin R. Sipido
Summary: Ischemic heart disease is a common cause of lethal ventricular arrhythmias and sudden cardiac death, with implantable cardioverter defibrillators and ablation therapy being the most effective treatments. Advances in mechanistic insights and technological innovation have led to improved interventional approaches, while pharmacological management still needs improvement.
Article
Cell Biology
Mattia La Torre, Eleonora Centofante, Carmine Nicoletti, Romina Burla, Alessandro Giampietro, Federica Cannistra, Leonardo Schirone, Valentina Valenti, Sebastiano Sciarretta, Antonio Musaro, Isabella Saggio
Summary: DNA damage is emerging as a key factor in the development of heart disease. This study investigates the role of Ft1 deficiency in cardiac defects and compares the impact of DNA damage targeted to vasculature smooth muscle cells versus diffuse damage. The results show that both Ft1ko and Ft1sm22ko mice display cardiac defects, but Ft1 deficiency targeted to smooth muscle cells exacerbates age-related pathological traits. Additionally, depletion of the DNA damage sensor p53 rescues the defects caused by Ft1 deficiency in the left ventricle and functional heart.
Article
Urology & Nephrology
Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P. C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joachim Jankowski, Leticia Prates Roma, Heidi Noels
Summary: Chronic kidney disease (CKD) increases the risk of developing uremic cardiomyopathy, and animal studies are used to investigate the underlying mechanisms. This review systematically analyzed 88 studies and performed meta-analyses of 52 to identify suitable animal models for future experimental studies. The results showed variations in different mouse strains and the effects of CKD on cardiac hypertrophy, fibrosis, and function. Multifactorial hit models consistently induced cardiac hypertrophy and fibrosis compared to single hit kidney injury models.
KIDNEY INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Hui-Hui Yang, Xiaohong Wang, Siru Li, Yueying Liu, Rubab Akbar, Guo-Chang Fan
Summary: The lipocalin (LCN) family members are small extracellular proteins with highly conserved tertiary structures and diverse functions. They can bind small hydrophobic ligands and interact with cell membrane receptors and soluble macromolecules. LCN family proteins are involved in the regulation of various physiological processes and human diseases. This review focuses on the structural and sequence properties of LCNs and highlights the diagnostic/prognostic values and potential effects of six LCNs in coronary artery disease and myocardial infarction injury. It also summarizes the roles of these LCNs in cardiac hypertrophy, heart failure, diabetes-induced cardiac disorder, and septic cardiomyopathy, as well as discusses their therapeutic potential for cardiovascular disease.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yinhui Wang, Kun Yu, Chengcheng Zhao, Ling Zhou, Jia Cheng, Dao Wen Wang, Chunxia Zhao
Summary: The study revealed that Follistatin plays a cardioprotective role in attenuating diabetic cardiomyopathy by reducing cardiac fibrosis and reactive oxygen species production, and enhancing matrix metallopeptidase 9 activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yongning Shang, Yulin Zhang, Weiling Leng, Xiaotian Lei, Liu Chen, Xiaoyue Zhou, Ziwen Liang, Jian Wang
Summary: Sex differences were observed in myocardial remodeling induced by type 2 diabetes mellitus (T2DM), with female patients showing concentric remodeling in left ventricular structure and male patients showing extracellular matrix remodeling and subclinical diastolic dysfunction.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Medicine, Research & Experimental
Weiwei Lu, Zhaojie Meng, Rebecca Hernandez, Changcheng Zhou
Summary: The study demonstrates the crucial role of IKK-beta in regulating fibroblast functions and cardiac remodeling, showing that fibroblast-specific IKK-beta deficiency can protect mice from hypertension-induced adverse cardiac remodeling, including hypertrophy, fibrosis, and macrophage infiltration. Ablation of fibroblast IKK-beta inhibits proinflammatory and profibrogenic responses, leading to improved cardiac remodeling and function.
Article
Nutrition & Dietetics
Xiaoning Cui, Ke Wang, Jinghua Zhang, Zhen-Bo Cao
Summary: Myocardial fibrosis is a crucial factor in the development of heart diseases associated with cardiovascular disease. Vitamin D deficiency promotes the development of cardiovascular disease, while exercise plays a role in its treatment. This study aimed to investigate the effects of 12-week aerobic exercise training on myocardial fibrosis in vitamin D-deficient mice.
Review
Immunology
Yingnan Liao, Kui Liu, Liyuan Zhu
Summary: Cardiovascular diseases are a major health problem globally, and inflammasomes play a significant role in these diseases. Among them, NLRP3 inflammasome has been extensively studied for its involvement in immune response and disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Pankaj Garg, Hosamadin Assadi, Rachel Jones, Wei Bin Chan, Peter Metherall, Richard Thomas, Rob van der Geest, Andrew J. Swift, Abdallah Al-Mohammad
Summary: CMR is helpful for prognostication in patients with HFpEF, where left ventricular fibrosis and hypertrophy are associated with all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Lin Peng, Tian-Jing Zhang, Ke Shi, Hai-Xia Li, Ying Li, Sen He, Chen Li, Dong Xia, Chun-Chao Xia, Zhen-Lin Li
Summary: The study investigated the feasibility of autoML based on native T1 mapping to predict LGE status in HCM patients. Results showed that TPOT modeling was effective in detecting LGE status and distinguishing between HCM patients and controls.
EUROPEAN RADIOLOGY
(2022)
Article
Medical Laboratory Technology
Finosh G. Thankam, Sharona Sedighim, Rebecca Kuan, Devendra K. Agrawal
Summary: The study suggests that ischemic insults activate epicardial adipose tissue-derived stem cells (EATDS) to secrete extracellular vesicles (EVs) containing regenerative mediators, which can alter gene expression in cardiac fibroblasts (CF). Results showed that the interaction between ischemia-induced EVs and CF cells led to the upregulation of cardiomyocyte-specific transcription factors and the downregulation of fibroblast and cardiac biomarkers, indicating a cardiomyocyte-like phenotype. The study also identified LGALS1, PRDX2, and CCL2 as potent protein mediators involved in regenerative processes. The findings highlight the potential of EATDS-derived EVs and sub-populations for improved cardiac healing following ischemic injury.
TRANSLATIONAL RESEARCH
(2023)
Article
Cell Biology
Vikrant Rai, Devendra K. Agrawal
Summary: Treatment of nonhealing diabetic foot ulcers is a major challenge and understanding the effects of sexual dimorphism and other related issues is crucial. However, there is a lack of data in this area. It is important to understand these aspects for choosing appropriate animal models and investigating therapeutic options.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Vikrant Rai, Rebecca Moellmer, Devendra K. Agrawal
Summary: Chronic diabetic foot ulcers (DFUs) can lead to amputation, increased morbidity and mortality, and economic stress. Fibroblast plasticity and heterogeneity, hyperglycemia, inflammatory cytokines, and interactions with other cells in the diabetic wound microenvironment play important roles in DFU healing. The different phenotypes of fibroblasts and their effects on angiogenesis in DFUs have not been thoroughly studied. This review aims to address these gaps in the field.
MOLECULAR BIOLOGY REPORTS
(2023)
Correction
Pharmacology & Pharmacy
Gunimat Samra, Vikrant Rai, Devendra K. Agrawal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vikrant Rai, Joe Abdo, Devendra K. Agrawal
Summary: Esophageal cancer is a highly fatal disease with limited screening techniques and low survival rates. Non-invasive biomarkers and diagnostic methods are needed for early detection and improved outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Parth Patel, Vikrant Rai, Devendra K. Agrawal
Summary: Atherosclerosis is a multifactorial inflammatory disease, characterized by plaque formation and hypoxic tissue due to vessel occlusion. Chronic inflammation and altered collagen expression contribute to plaque vulnerability, leading to acute ischemic events. Inflammatory mediators, including TREM-1, TLRs, MMPs, and immune cells, play a critical role in plaque vulnerability.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Prathosh Velpuri, Vikrant Rai, Devendra K. Agrawal
Summary: Atherosclerosis is a disease characterized by the formation of plaques in the blood vessels, resulting in reduced blood flow and oxygen deprivation to organs. Chronic inflammation plays a crucial role in plaque instability and rupture, leading to cardiovascular events. Sirtuins have been identified as potential targets for controlling plaque progression and vulnerability due to their involvement in inflammation and oxidative stress.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Oncology
Hafiza Padinharayil, Vikrant Rai, Alex George
Summary: In cancer therapy, targeting mitochondrial metabolism has become an attractive strategy, especially for pancreatic ductal adenocarcinoma (PDAC) which is resistant to treatment. Along with other approaches, mitochondrial oxidative phosphorylation (OXPHOS) remains a key target. Understanding how pancreatic cancer cells control mitochondrial metabolism and its role in PDAC progression can lead to the development of more effective therapeutics.
Review
Immunology
Armand N. Yazdani, Nathaniel DeMarco, Parth Patel, Arian Abdi, Prathosh Velpuri, Devendra K. Agrawal, Vikrant Rai
Summary: The SARS-CoV-2 virus and the COVID-19 pandemic have had a significant impact on patients with hematological conditions, particularly those who are immunocompromised. Vaccination efforts have increased to protect this vulnerable population, but there are reported side effects and concerns about the vaccine's effectiveness for patients with hematological conditions. This review aims to provide critical hematological information on COVID-19 vaccination for clinicians and to clarify the adverse hematological effects associated with infection and vaccination within the general population.
Article
Pharmacology & Pharmacy
Vikrant Rai, Hoangvi Le, Devendra K. Agrawal
Summary: A non-healing diabetic foot ulcer (DFU) is a significant clinical problem with socioeconomic and psychosocial burdens. Current therapies for DFU, such as wound debridement and growth factors, have limited success in promoting angiogenesis and healing. Poor angiogenesis due to decreased expression of angiogenic mediators and matrix formation leads to nonhealing ulcers and amputation. This article critically reviews existing pro-angiogenic mediators and explores potential novel factors that may enhance angiogenesis and wound healing in DFUs.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Armand N. Yazdani, Michaela Pletsch, Abraham Chorbajian, David Zitser, Vikrant Rai, Devendra K. Agrawal
Summary: To effectively monitor CAD, it is important to identify key biomarkers for assessing disease severity and progression. This review discusses the most relevant markers for monitoring CAD prognosis and highlights the potential of using these markers in therapeutic interventions. By utilizing these markers, healthcare providers can improve patient care, optimize treatment plans, and reduce healthcare costs associated with CAD management.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
