Article
Cell Biology
Chien-Ting Wu, Peter Lidsky, Yinghong Xiao, Ivan T. Lee, Ran Cheng, Tsuguhisa Nakayama, Sizun Jiang, Janos Demeter, Romina J. Bevacqua, Charles A. Chang, Robert L. Whitener, Anna K. Stalder, Bokai Zhu, Han Chen, Yury Goltsev, Alexandar Tzankov, Jayakar Nayak, Garry P. Nolan, Matthias S. Matter, Raul Andino, Peter K. Jackson
Summary: There is evidence suggesting a complex relationship between COVID-19 and diabetes, with SARS-CoV-2 being able to directly induce beta cell killing and this effect being rescued by NRP1 inhibition.
Article
Endocrinology & Metabolism
Anais Schaschkow, Lokman Pang, Valerie Vandenbempt, Bernat Elvira, Sara A. Litwak, Beata Vekeriotaite, Elisa Maillard, Marjorie Vermeersch, Flavia M. M. Paula, Michel Pinget, David Perez-Morga, Daniel J. Gough, Esteban N. Gurzov
Summary: This study suggests that STAT3 may be a novel regulator of beta-cell function in obesity, with its deficiency leading to impaired glucose tolerance and reduced expression of mitochondrial genes.
Article
Biochemistry & Molecular Biology
Layanne Nascimento Fraga, Sara Lima Anacleto, Dragan Milenkovic, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto
Summary: Citrus flavanone metabolites H7G and PA can protect pancreatic beta-cells against stress induced by cholesterol through multi-proteomic mechanisms.
Article
Cell Biology
Kedar Ghimire, Atharva Kale, Jennifer Li, Sohel M. Julovi, Philip O'Connell, Shane T. Grey, Wayne J. Hawthorne, Jenny E. Gunton, Natasha M. Rogers
Summary: CD47 is a molecule that regulates insulin secretion and plays an important role in pancreatic beta cells. Its depletion can stimulate insulin secretion and improve insulin sensitivity. Blocking CD47 with drugs can enhance islet transplantation efficiency and restore normal blood glucose levels in diabetic mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Zhengwei Zhang, Beier Tong, Jie Liu, Jieyuan Feng, Linyang Song, Huawei Wang, Mengting Ke, Chengkai Xu, Yancheng Xu
Summary: This study revealed the effects of interfering with PP2Ac gene expression on pancreatic beta-cells in vivo and in vitro and the underlying mechanisms, which may provide insights for the treatment of type 2 diabetes mellitus in the clinic.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Cell Biology
Jungwon Wee, Sungmin Pak, Tahnbee Kim, Gyu-Sang Hong, Ji Seon Lee, Jinyan Nan, Hyungsup Kim, Mi-Ock Lee, Kyong Soo Park, Uhtaek Oh
Summary: Insulin plays a critical role in regulating glucose homeostasis, while the mechanosensitive channel Tentonin 3/TMEM150C (TTN3) is involved in glucose-stimulated insulin secretion by mediating cation influx in beta-cells.
Article
Medicine, Research & Experimental
Peng Wang, Esra Karakose, Carmen Argmann, Huan Wang, Metodi Balev, Rachel Brody, Hembly G. Rivas, Xinyue Liu, Olivia Wood, Hongtao Liu, Lauryn Choleva, Dan Hasson, Emily Bernstein, Joao A. Paulo, Donald K. Scott, Luca Lambertini, James A. DeCaprio, Andrew F. Stewart
Summary: Resistance to regeneration of insulin-producing pancreatic β cells is a challenge in diabetes. Small molecule inhibitors of DYRK1A kinase have been found to induce proliferation of adult human β cells, but their mechanism of action is not fully understood. Through analysis of transcriptomic databases, researchers identified the DREAM complex as a central regulator of quiescence in human β cells. The DREAM complex consists of transcriptionally repressive proteins that assemble in response to DYRK1A kinase activity, inducing and maintaining cellular quiescence.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Stefanie Maria Werhahn, Julia S. Kreusser, Marco Hagenmuller, Jan Beckendorf, Nathalie Diemert, Sophia Hoffmann, Jobst-Hendrik Schultz, Johannes Backs, Matthias Dewenter
Summary: Chronic isoproterenol (ISO) infusion induces both maladaptive remodelling and adaptive PKA signalling to maintain cardiac function, highlighting the complex role of beta-adrenergic signaling in heart failure._Stoppage of ISO leads to progressive worsening of cardiac function, indicating the delicate balance between adaptive and maladaptive effects of beta-adrenergic stimulation.
Article
Environmental Sciences
Xiaowei He, Dan Wu, Yanan Xu, Yaqin Zhang, Yue Sun, Xiaoai Chang, Yunxia Zhu, Wei Tang
Summary: This study found that PFOA leads to damage and apoptosis of pancreatic beta cells, resulting in reduced insulin secretion. The increased expression of ER stress-related genes, particularly Trib3, contributes to this process. Inhibiting Trib3 expression can protect beta cells from PFOA-induced damage and apoptosis by alleviating ER stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yuki Nishimura, Misaki Iwashita, Masato Hayashi, Takanori Shinjo, Yukari Watanabe, Tatsuro Zeze, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomomi Sano, Tomoichiro Asano, Fusanori Nishimura
Summary: This study investigated the effects of XAF1 on beta-cell function and progression of diabetes, and found that high-fat diet upregulated XAF1 expression in pancreatic islets through macrophage-derived IFN beta, which promoted beta-cell apoptosis, reduced insulin expression, and exacerbated diabetes.
ACTA DIABETOLOGICA
(2022)
Article
Surgery
Elisa Bannone, Giovanni Marchegiani, Alberto Balduzzi, Giuseppa Procida, Pier Giuseppe Vacca, Roberto Salvia, Claudio Bassi
Summary: The objective of this study was to characterize early postoperative serum pancreatic amylase (spAMY) trends after pancreatic resections. Three patterns of spAMY were identified, and a sustained increase in spAMY activity on POD 1 + 2 was associated with overall and severe early morbidity. Early and dynamic evaluation of spAMY could have important prognostic implications.
Article
Chemistry, Medicinal
Min Hee Yang, Seung Ho Baek, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kwang Seok Ahn
Summary: Protocatechuic acid (PA) has been found to suppress and reverse the EMT process in tumor cells, reducing their invasive and metastatic potential. Additionally, PA exerts its effects by influencing the PI3K/Akt/mTOR signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Myeong-Seong Seo, Kyung Hee Jung, Kewon Kim, Ji Eun Lee, Beom Seok Han, Soyeon Ko, Jae Ho Kim, Sungwoo Hong, So Ha Lee, Soon-Sun Hong
Summary: The novel NUAK1 inhibitor, KI-301670, effectively inhibits pancreatic cancer growth and proliferation, induces cell cycle arrest and apoptotic effect, and inhibits migration and invasion of cancer cells by targeting the PI3K/AKT pathway. It also shows significant tumor growth inhibition in a mouse xenograft tumor model, suggesting its potential as a therapeutic candidate for pancreatic cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Ye-Jee Lee, Esder Lee, Young-Hye You, Yu-Bae Ahn, Ki-Ho Song, Ji-Won Kim, Seung-Hyun Ko
Summary: Under hypoxic conditions, reduced SIRT1 expression in pancreatic beta-cells leads to decreased cell viability and increased levels of inflammatory cytokines, which can be ameliorated by activating SIRT1.
JOURNAL OF DRUG TARGETING
(2021)
Article
Oncology
Sharavan Ramachandran, Itishree S. Kaushik, Sanjay K. Srivastava
Summary: Pimavanserin, as a novel anti-psychotic drug, shows potential as a treatment option for pancreatic cancer by suppressing the growth of pancreatic tumors through inducing autophagy-mediated apoptosis. The study found that Pimavanserin treatment led to increased autophagy and apoptosis in pancreatic ductal adenocarcinoma cells, supporting its role in tumor growth suppression.
Article
Biochemistry & Molecular Biology
Siyuan Dong, Yanni Yang, Biqi He, Zhao Xu, Zhaoqiang Zhou, Jinhai Wang, Chen Chen, Qun Chen
Summary: Fluorosis causes female reproductive dysfunction and reduced fertility, but the underlying mechanism is still unclear. This study found that NaF treatment significantly reduced body weight and pregnancy rate in female rats, while inhibiting the secretion of hormones and estradiol. SIRT1 may be involved in this NaF-induced reproductive dysfunction in female rats through regulating reproductive hormone secretion.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qun Chen, Xibin Kao, Yan Gao, Jinghong Chen, Zhaoheng Dong, Chen Chen
Summary: The study investigated the role of cytoskeletal proteins in chondrocyte apoptosis induced by SNP, finding that the JNK/ERK pathways have opposite effects on cytoskeletal proteins, with the ERK pathway protecting the proteins from dissolution through inhibition of caspase-3 activation while the JNK pathway promoting dissolution through activation of caspase-3 activity.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hui Wang, Zhengzheng Li, Yinan Liu, Meng Zhang, Yawen Shi, Ying Zhang, Ge Mi, Mengying Wang, Ying He, Yonghui Chen, Chen Chen, Jinghong Chen
Summary: SelS is a selenium-sensitive protein involved in various biological processes in chondrocytes, including ER stress. Knocking down SelS results in abnormal expression of adhesion molecules and matrix homeostasis in hypertrophic chondrocytes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Qun Chen, Xibin Kao, Yan Gao, Jinghong Chen, Zhaoheng Dong, Chen Chen
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Li-Sha Ran, Ya-Zeng Wu, Yi-Wen Gan, Hong-Lian Wang, Li-Juan Wu, Chun-Mei Zheng, Yao Ming, Ran Xiong, Yong-Lin Li, Shi-Hang Lei, Xue Wang, Xiao-Qing Lao, Hong-Min Zhang, Li Wang, Chen Chen, Chang-Ying Zhao
Summary: This study found that andrographolide can alleviate hepatic steatosis by suppressing FATP2-mediated fatty acid uptake, suggesting its potential therapeutic application in the treatment of nonalcoholic fatty liver disease (NAFLD).
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Medicine, General & Internal
Xin Zhou, Yanping Wang, Wenyun Chen, Hongmin Zhang, Yirui He, Han Dai, Wenjing Hu, Ke Li, Lili Zhang, Chen Chen, Gangyi Yang, Ling Li
Summary: This study found that serum human hedgehog-interacting protein (HHIP) concentration is associated with diabetes. The relationship between HHIP and polycystic ovary syndrome (PCOS) or abnormal sex hormones remains unknown. Bioinformatics analysis revealed the association of PCOS with metabolic-related genes and signaling pathways. HHIP may serve as a useful biomarker and novel drug target for PCOS and insulin resistance individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Education, Scientific Disciplines
Yangting Xu, Chen Chen, Ming Ji, Yang Xiang, Yang Han, Dandan Feng, Ziqiang Luo
Summary: The online flipped classroom is a new teaching method in universities that combines asynchronous and synchronous online learning. In terms of overall exam scores, the online flipped classroom and online live teaching showed no significant difference. However, the online flipped classroom had a more positive impact on high-achieving students, particularly in short answer questions and courses requiring logical thinking. The performance of low-achieving students in case study questions was lower in the online flipped classroom. Further research is needed to understand the reasons behind this and develop strategies to improve their learning outcomes.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Correction
Pharmacology & Pharmacy
Wenrong Li, Siyuan Dong, Qun Chen, Chen Chen, Zhaoheng Dong
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Jing-Tian Zhang, Li -Ya Xie, Qiong Shen, Wei Liu, Ming -Han Li, Rui-Yi Hu, Jun-Nan Hu, Zi Wang, Chen Chen, Wei Li
Summary: This study investigated the regulatory effects of Platycodin D (PD) on neurodegeneration caused by reactive oxidative stress (ROS). In vivo and in vitro experiments demonstrated that PD could improve memory, reduce cell apoptosis and ROS production, and inhibit inflammation. PD enhanced the antioxidant ability by activating AMPK. This study suggests that PD may be a potential pharmaceutical agent to treat ROS-induced neurodegeneration.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yue Zhang, He Xian, Ekaterina Strounina, Kimberley S. Gunther, Matthew J. Sweet, Chen Chen, Chengzhong Yu, Yue Wang
Summary: In this study, tetrasulphide bridged mesoporous organosilica nanoparticles (MONs) were found to have enhanced transfection performance of plasmid DNA (pDNA) in dendritic cell (DC) lines compared to conventional mesoporous silica nanoparticles (MSNs). This enhancement is attributed to the glutathione (GSH) depletion capability of MONs, which increases the activation of the mammalian target of rapamycin complex 1 (mTORc1) pathway and enhances translation and protein expression. The increased transfection efficiency was only observed in high GSH cell lines, validating the mechanism. This study provides a new design principle for nano delivery systems targeting pDNA delivery to DCs.
Article
Computer Science, Hardware & Architecture
Yanjun Zhang, Guangdong Bai, Xue Li, Surya Nepal, Marthie Grobler, Chen Chen, Ryan K. L. Ko
Summary: Genome-wide analysis has health and social benefits, but sharing such data may risk revealing sensitive information. Identity tracing attack exploits correlations among genomic data to reveal the identity of DNA samples. This paper proposes a framework called "F-RAG" to enable privacy-preserving data sharing and computation in genome-wide analysis, mitigating privacy risks without compromising utility.
IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING
(2023)
Review
Agriculture, Multidisciplinary
Lin Li, Ruiyuan Zhang, Yichen Hu, Hongdan Deng, Xu Pei, Fang Liu, Chen Chen
Summary: This review provides up-to-date information on the effects of oat and its constituents on metabolic syndrome, highlighting their potential applications in functional foods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Wanlong Zhang, Changhua Zhang, Lan Cao, Fang Liang, Weihua Xie, Liang Tao, Chen Chen, Ming Yang, Lingyun Zhong
Summary: Processing of Chinese Materia Medica (PCMM) is the core of traditional pharmaceutical technology in China, involving steps like cleansing and stir-frying to impact the quality and efficacy of Chinese botanical drugs. The rapid development of digital technologies has promoted the digitalization and intellectualization of traditional pharmaceutical manufacturing industry. This review analyzes and discusses the application of digital intelligence technology in PCMM, aiming to promote process standardization and ensure the quality of botanical drugs decoction pieces.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Ming-Fei Du, Xi Zhang, Gui-Lin Hu, Jian-Jun Mu, Chao Chu, Yue-Yuan Liao, Chen Chen, Dan Wang, Qiong Ma, Yu Yan, Hao Jia, Ke-Ke Wang, Yue Sun, Ze-Jiaxin Niu, Zi-Yue Man, Lan Wang, Xiao-Yu Zhang, Wen-Jing Luo, Wei-Hua Gao, Hao Li, Guan-Ji Wu, Ke Gao, Jie Zhang, Yang Wang
Summary: This study aimed to examine and compare the predictive values of three novel obesity indices--LAP, VAI, and TyG index--for cardiovascular subclinical organ damage in a Chinese adult population. The results showed that LAP, VAI, and TyG index demonstrated utility in screening cardiovascular subclinical organ damage, with TyG index showing the highest predictive value. These indices have the potential to serve as markers for early detection of cardiovascular disease in otherwise healthy individuals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Oncology
Hongzhuo Li, Wenyi Gu, Penny Jeffery, Chen Chen
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)