期刊
ADIPOCYTE
卷 5, 期 3, 页码 318-325出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2015.1137689
关键词
alternative splicing; hormones; insulin; regulated membrane fusion; SNARE
资金
- Swedish Research Council
- Family Erling-Persson Foundation
- Karolinska Institutet Funds
- Magnus Bergvall's Foundation
- Gun and Bertil Stohne's Foundation
- Langmanska Kulturfonden
- Fogelstrom's Foundation
- Sven Mattsson's Foundation
The exocytosis of signaling molecules from neuronal, neuroendocrine and endocrine cells is regulated by membrane fusion involving SNAP-25 and associated SNARE proteins. The importance of this process for metabolic control recently became evident by studies of mouse mutants genetically engineered to only express one of 2 closely related, alternatively-spliced variants of SNAP-25. The results showed that even minor differences in the function of proteins regulating exocytosis are sufficient to provoke metabolic disease, including hyperglycaemia, liver steatosis, adipocyte hypertrophy and obesity. Thus, an imbalance in the dynamics of hormonal and/or neurotransmitter release can cause obesity and type 2 diabetes. This recent discovery highlights the fact that metabolic health requires a perfectly operating interplay between the SNARE protein machinery in excitable cells and the organs responding to these messengers.
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