期刊
OPEN FORUM INFECTIOUS DISEASES
卷 3, 期 2, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofw090
关键词
carbapenemase; child; drug resistance; Enterobacteriaceae; epidemiology
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [K08AI112506, R01AI072219, R01AI063517, R01AI100560]
- Department of Veterans Affairs Research and Development [I01BX001974]
- VISN 10 Geriatrics Research, Education and Clinical Center
Metallo-beta-lactamases (MBLs) are emerging as the most notable resistance determinants in Enterobacteriaceae. In many cases, the genes encoding MBLs are part of complex, mobile genetic elements that carry other resistance determinants. In the United States, there are increasing reports of MBL-producing Enterobacteriaceae, with New Delhi MBLs (NDMs) accounting for the majority of transmissible MBL infections. Many infections caused by NDM-producing bacteria are associated with international travel and medical tourism. However, little recognition of the introduction of MBL-producing Enterobacteriaceae into the pediatric community has followed. Reports suggest that this occurred as early as 2002. Here, we reflect on the unwelcome emergence of MBL-producing Enterobacteriaceae in US children and the available clinical and molecular data associated with spread. Since 2002, there have been disturbing reports that include the most readily transmissible MBLs, bla(IMP), bla(VIM), and bla(NDM) types. In the majority of children with available data, a history of foreign travel is absent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据