Aberrant Promoter Hypomethylation in CLL: Does It Matter for Disease Development?

DNA methylation in normal and malignant hematopoiesis

(2016) Hamza Celik et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

(2016) S. E. Meyer et al.   Cancer Discovery

Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a

(2016) Staci L. Haney et al.   Cell Reports

Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells

(2015) O A Guryanova et al.   LEUKEMIA

AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation

(2015) X N Gao et al.   LEUKEMIA

Loss of Dnmt3a and endogenous Kras G12D/+ cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis

(2015) Y-I Chang et al.   LEUKEMIA

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

(2015) S L Haney et al.   ONCOGENE

Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis

(2014) M. Chadeau-Hyam et al.   ANNALS OF ONCOLOGY

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

(2014) H. Celik et al.   BLOOD

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

(2014) A. Mayle et al.   BLOOD

Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells

(2014) Grant A. Challen et al.   Cell Stem Cell

Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia

(2014) Mirjam Hoxha et al.   GENES CHROMOSOMES & CANCER

Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis

(2013) A. Vasanthakumar et al.   BLOOD

Accelerated progression of chronic lymphocytic leukemia in E -TCL1 mice expressing catalytically inactive RAG1

(2013) V. K. Nganga et al.   BLOOD

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

(2013) S L Peters et al.   LEUKEMIA

Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia

(2013) Cecilia Abreu et al.   LEUKEMIA & LYMPHOMA

Essential Role for Dnmt1 in the Prevention and Maintenance of MYC-Induced T-Cell Lymphomas

(2013) S. L. Peters et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia

(2012) Lirong Pei et al.   Epigenetics

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains

(2012) J. J. Trowbridge et al.   GENES & DEVELOPMENT

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia

(2012) Marta Kulis et al.   NATURE GENETICS

Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)

(2012) A. Palamarchuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

(2011) Ryan A. Hlady et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group

(2010) Torsten Haferlach et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications

(2009) M. T. McCabe et al.   CLINICAL CANCER RESEARCH

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

(2009) Ann-Marie Bröske et al.   NATURE GENETICS

The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24

(2008) K. Huppi et al.   MOLECULAR CANCER RESEARCH

Pvt1-encoded microRNAs in oncogenesis

(2008) Gabriele B Beck-Engeser et al.   Retrovirology