Article
Behavioral Sciences
Eri Tajiri, Eiichi Yoshimura, Takuro Tobina, Tomoki Yamashita, Kokoro Kume, Yoichi Hatamoto, Seiya Shimoda
Summary: This study investigated the changes in subjective psychological factors and dietary intake during sleep restriction. The findings showed that ratings for subjective psychological factors and energy and carbohydrate intakes from snacks increased under the condition of sleep restriction.
Article
Food Science & Technology
Hanne Pedersen, Jonas Salling Quist, Marie Moller Jensen, Kim Katrine Bjerring Clemmensen, Dorte Vistisen, Marit Eika Jorgensen, Kristine Faerch, Graham Finlayson
Summary: This study examined how biometric responses differ in foods varying in fat and taste, and found positive associations between attention and subsequent food reward and intake. The findings suggest that implicit biometric responses to food cues can predict both food reward and actual food intake.
FOOD QUALITY AND PREFERENCE
(2021)
Article
Psychology, Biological
Leticia E. Sewaybricker, Susan J. Melhorn, Jennifer L. Rosenbaum, Mary K. Askren, Vidhi Tyagi, Mary F. Webb, Mary Rosalynn B. De Leon, Thomas J. Grabowski, Ellen A. Schur
Summary: In a study involving a majority of overweight or obese adult twins, the level of adiposity was not associated with excess appetitive drive.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Nutrition & Dietetics
Jennifer A. Nasser, Eram Albajri, Lisa Lanza, Abigail Gilman, Mansour Altayyar, Dimitra Thomopoulos, Michael Bruneau
Summary: This study found that consuming a high-protein preload before eating ultra-processed snack food can reduce caloric intake, potentially leading to weight loss.
Article
Nutrition & Dietetics
Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada
Summary: d-allulose can suppress hunger-associated feeding and inhibit hunger-promoting neurons in the hypothalamic arcuate nucleus.
Review
Chemistry, Medicinal
Mahtab Zarei, Shaghayegh Adeli, Shabnam Hosseini, Elnaz Daneshzad
Summary: This study comprehensively reviewed the effect of flaxseed on appetite perception. Although the results were inconsistent, some studies found a significant reduction in hunger and appetite, as well as an increase in fullness and satiety.
PHYTOTHERAPY RESEARCH
(2022)
Article
Nutrition & Dietetics
Angelo Tremblay, Mikael Fogelholm, Elli Jalo, Margriet S. Westerterp-Plantenga, Tanja C. Adam, Maija Huttunen-Lenz, Gareth Stratton, Tony Lam, Teodora Handjieva-Darlenska, Svetoslav Handjiev, J. Alfredo Martinez, Ian A. Macdonald, Elizabeth J. Simpson, Jennie Brand-Miller, Roslyn Muirhead, Sally D. Poppitt, Marta P. Silvestre, Thomas M. Larsen, Pia Siig Vestentoft, Wolfgang Schlicht, Vicky Drapeau, Anne Raben
Summary: The study found that overweight individuals with pre-diabetes who failed to achieve a body weight loss of >= 8% of the baseline value after a 2-month low-energy diet maintained a lower daily energy deficit and had less favorable changes in susceptibility to hunger and appetite sensations. Additionally, they did not benefit in terms of improving sleep quality. These results indicate that these individuals may have behavioral vulnerability that could be exacerbated by prolonged diet restriction.
FRONTIERS IN NUTRITION
(2021)
Review
Nutrition & Dietetics
Vinicius M. Valicente, Ching-Hsuan Peng, Kathryn N. Pacheco, Luotao Lin, Elizabeth I. Kielb, Elina Dawoodani, Afsoun Abdollahi, Richard D. Mattes
Summary: Epidemiological evidence suggests a positive association between consuming ultraprocessed foods (UPFs) and body mass index, although causality is not well-established. This review evaluates various mechanisms related to food choice, composition, and digestive processes to determine the specific effects of UPFs. The findings indicate that some proposed mechanisms do not support a unique contribution of UPFs, while data is insufficient or unavailable for other mechanisms. Additionally, evidence suggests that certain ingredients in UPFs may actually influence body weight. It is important to verify causality and understand plausible mechanisms before making recommendations about the role of UPFs in diets.
ADVANCES IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Rodrigo Chamorro, Marcelo Garrido, Cecilia Algarin, Betsy Lozoff, Patricio Peirano
Summary: Experimental studies found a close link between acute sleep restriction and metabolic disorders. This study showed that a single night of moderate sleep restriction at home resulted in increased food intake, feelings of hunger, and impaired regulation of blood pressure and heart rate in overweight young adults.
Article
Behavioral Sciences
Nicole T. Crane, Meghan L. Butryn, Amy A. Gorin, Michael R. Lowe, Erica M. LaFata
Summary: Hedonic hunger, a reward-driven eating behavior, is associated with weight loss during behavioral weight loss, but its predictive power is unclear when considering other similar constructs. The study also found that contextual factors, such as the home food environment, did not predict weight loss, regardless of levels of hedonic hunger. This research provides valuable information for improving conceptual models and treatment strategies for weight control.
Article
Nutrition & Dietetics
Nicole Fearnbach, Amanda E. Staiano, Neil M. Johannsen, Daniel S. Hsia, Robbie A. Beyl, Owen T. Carmichael, Corby K. Martin
Summary: Exercise may impact energy intake in adolescents by influencing appetite states rather than traits. Additionally, baseline energy intake after exercise is associated with weight change over time, indicating that appetitive cues play a significant role in post-exercise energy intake.
Article
Nutrition & Dietetics
Agata Chmurzynska, Monika A. Mlodzik-Czyzewska, Anna Radziejewska, Douglas J. Wiebe
Summary: The study found that hedonic hunger is related to the intake of specific types of high-fat food, but not with total intake. The interaction between OPRM1 genotype and hedonic hunger affects fast-food intake. Total hedonic hunger and some aspects of hedonic hunger are associated with BMI.
JOURNAL OF NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Naima Covassin, Prachi Singh, Shelly K. McCrady-Spitzer, Erik K. St Louis, Andrew D. Calvin, James A. Levine, Virend K. Somers
Summary: Sleep deficiency combined with ad libitum food intake promotes excess energy intake without affecting energy expenditure. Weight gain, especially central accumulation of fat, indicates that sleep loss predisposes individuals to abdominal visceral obesity.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Food Science & Technology
Tobias Otterbring, Michal Folwarczny, Kerstin Gidlof
Summary: Studies have found that hunger levels influence consumers' food choices and preference patterns, particularly in the selection of utilitarian foods. Hungry consumers have lower option quality for utilitarian foods and perform worse on cognitively demanding tasks.
FOOD QUALITY AND PREFERENCE
(2023)
Article
Psychology, Biological
Lena Pelissier, Valerie Julian, Kristine Beaulieu, Julie Siroux, Audrey Boscaro, Alicia Fillon, Graham Finlayson, Martine Duclos, Yves Boirie, Bruno Pereira, Laurie Isacco, David Thivel
Summary: This study compared the effects of equivalent energy deficits induced by dietary restriction alone and combined with exercise on appetite responses in adolescents with obesity. The results showed that neither of the two deficits led to subsequent appetitive compensation, with the dietary deficit even inducing a lower ad libitum energy intake at the subsequent dinner. Further research is needed to better understand the appetitive response to dietary and exercise energy balance manipulations in this population.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Xiaojie Liu, Hao Yu, Bixuan Chen, Vladislav Friedman, Lianwei Mu, Thomas J. Kelly, Gonzalo Ruiz-Perez, Li Zhao, Xiaowen Bai, Cecilia J. Hillard, Qing-song Liu
Summary: The study found that CB2 agonists ameliorate anxiogenic and depressive-like behaviors in Parkinson's disease models, possibly through neuroprotective mechanisms.
Article
Biochemistry & Molecular Biology
Colleen M. Trevino, Cecilia J. Hillard, Aniko Szabo, Terri A. deRoon-Cassini
Summary: This study found an association between immediate endocannabinoid concentrations after trauma and chronic pain, suggesting that excessive activation of the endocannabinoid signaling pathway increases the risk for chronic pain development.
Article
Physiology
Victoria Woyach, Katherine Sherman, Cecilia J. Hillard, Francis A. Hopp, Quinn H. Hogan, Caron Dean
Summary: The complexity of neuropathic pain and its associated comorbidities make it difficult to treat. The dorsal periaqueductal gray (dPAG) plays a crucial role in both pain modulation and the regulation of sympathetic activity. Manipulation of the endocannabinoid signaling system shows promise in providing analgesia and normalizing autonomic function in neuropathic pain.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Neurosciences
Cesar E. Martinez Ramirez, Gonzalo Ruiz-Perez, Todd M. Stollenwerk, Christina Behlke, Ashley Doherty, Cecilia J. Hillard
Summary: It is difficult to underestimate the impact of the endocannabinoid signaling system on central nervous system function. Research on the ECS system continues to amaze and confuse, with CB1 and CB2 cannabinoid receptors playing important roles in cell-cell communication and regulating various brain functions. While preclinical studies are providing valuable insights, there is still much to learn about this versatile modulatory system.
Letter
Hematology
Jennifer M. Knight, Edward Hackett, Aniko Szabo, Ruizhe Wu, Garrett Sauber, Bryon Johnson, Rachel N. Cusatis, Elizabeth Aughey, Steve W. Cole, Cecilia J. Hillard, Nirav N. Shah
Editorial Material
Pharmacology & Pharmacy
Reem Smoum, Uwe Grether, Meliha Karsak, Andrea J. Vernall, Frank Park, Cecilia J. Hillard, Pal Pacher
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Clinical
Carissa W. Tomas, Jacklynn M. Fitzgerald, Carisa Bergner, Cecilia J. Hillard, Christine L. Larson, Terri A. deroon-Cassini
Summary: Predicting the development of posttraumatic stress disorder (PTSD) after traumatic injury is difficult due to its heterogeneity. Recent machine learning approaches have provided insights into predicting PTSD symptom trajectories. By using eXtreme Gradient Boosting (XGB), different PTSD symptom trajectories were identified. However, the prediction accuracy on discharged patients was limited.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Neurosciences
Itziar Terradillos, Itziar Bonilla-Del Rio, Nagore Puente, Maitane Serrano, Amaia Mimenza, Leire Lekunberri, Ilazki Anaut-Lusar, Leire Reguero, Inmaculada Gerrikagoitia, Samuel Ruiz de Martin Esteban, Cecilia J. Hillard, Maria T. Grande, Julian Romero, Izaskun Elezgarai, Pedro Grandes
Summary: In Alzheimer's disease, the expression of the CB1 receptor increases in reactive microglia, but remains constant in astrocytes, with CB1 receptor labeling proportionally increasing with the perimeter of reactive astrocytes. These findings contribute to the understanding of the role of the endocannabinoid system in the pathophysiology of Alzheimer's disease.
Article
Pharmacology & Pharmacy
Lawrence M. Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G. Hohmann
Summary: This study suggests that CB2 activation may alleviate HIV-associated antiretroviral neuropathy and identifies a previously unreported mechanism through which CB2 activation produces antinociceptive efficacy. The study also demonstrates that a CB2 agonist can reverse established morphine tolerance and shows that CB2 localized to peripheral sensory neurons mediates the opioid tolerance sparing efficacy of CB2 agonists.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Psychology, Clinical
Chloe Botsford, Angelique G. Brellenthin, Josh M. Cisler, Cecilia J. Hillard, Kelli F. Koltyn, Kevin M. Crombie
Summary: Recent research has explored the connection between blood-based biomarkers (such as endocannabinoids; eCBs: including N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) and mental health outcomes in psychiatric populations, especially posttraumatic stress disorder (PTSD). The findings suggest that there may be alterations in circulating eCBs and their response to stress in individuals with PTSD, and that moderate-intensity aerobic exercise can increase circulating eCBs in women with and without PTSD.
JOURNAL OF ANXIETY DISORDERS
(2023)
Article
Neurosciences
Jayme R. McReynolds, Colten P. Wolf, Dylan M. Starck, Jacob C. Mathy, Rebecca Schaps, Leslie A. Krause, Cecilia J. Hillard, John R. Mantsch
Summary: Stress promotes drug use in individuals with substance use disorders (SUDs). The CB1 cannabinoid receptor plays a crucial role in the stress-induced escalation of cocaine self-administration in male rats. The mesolimbic CB1 receptors are required for increased intake and heightened relapse susceptibility, suggesting that repeated stress at the time of cocaine use regulates CB1 receptor activity, though the exact mechanism is still unknown.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Kelsey G. Guenther, Zhili Xu, Julian Romero, Cecilia J. Hillard, Ken Mackie, Andrea G. Hohmann
Summary: CB2 agonists can suppress pathological pain in animal models without unwanted side effects associated with CB1 receptor activation. However, the specific types of pain responsive to CB2 agonists and the cell types underlying therapeutic efficacy are not fully understood.
Article
Biochemistry & Molecular Biology
Anna Portugalov, Hiba Zaidan, Inna Gaisler-Salomon, Cecilia J. J. Hillard, Irit Akirav
Summary: Early life stress (ELS) increases susceptibility to depression, and treatment with the FAAH inhibitor URB597 can reverse ELS-induced depressive-like behavior and specific miR downregulation, revealing a novel mechanism for the beneficial effects of FAAH inhibition. The differential effects of ELS and URB597 on males and females highlight the importance of developing sex-specific treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Mallory R. Taylor, Cecilia J. Hillard, William R. Drobyski, Aniko Szabo, Bryon D. Johnson, Fenlu Zhu, Charles L. Raison, Steve W. Cole, Jennifer M. Knight
Summary: This study explored the relationship between inflammatory biomarkers and patient-reported outcomes (PROs) in patients undergoing HCT treated with tocilizumab, finding that this treatment did not improve patient-reported symptoms. Larger prospective translational studies in biobehavioral HCT research are needed to further investigate this relationship.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Gabriel Forn-Cuni, Patrick Pfaff, Roman C. Sarott, Matthias Westphal, Yelena Mostinski, Leonard Mach, Malgorzata Wasinska-Kalwa, Marie Weise, Bradley L. Hoare, Tamara Miljus, Maira Mexi, Nicolas Roth, Eline J. Koers, Wolfgang Guba, Andre Alker, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Matthias Nettekoven, Irene Benito-Cuesta, Teresa Grande, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Michael Honer, Jurgen Fingerle, Joerg Scheffel, Johannes Broichhagen, Klaus Gawrisch, Julian Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jurg Gertsch, Christoph Ullmer, Peter J. McCormick, Sergio Oddi, Herman P. Spaink, Mauro Maccarrone, Dmitry B. Veprintsev, Erick M. Carreira, Uwe Grether, Marc Nazare
Summary: This study reports the development of a novel fluorescent CB2R agonist probe that can detect CB2R in living cells and zebrafish larvae. These findings contribute to the clinical translatability of CB2R-based drugs.