Review
Endocrinology & Metabolism
Wencai Wang, Luyao Ma, Yongqiang Zhao, Menghao Liu, Wei Ye, Xianfeng Li
Summary: This article reviews the pathogenesis of pituitary adenoma and the role of the Wnt signaling pathway. It discusses the potential of combining Wnt pathway inhibitors with immunotherapy for the treatment of pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Ann Neiheisel, Manpreet Kaur, Nancy Ma, Patty Havard, Anitha K. Shenoy
Summary: The Wnt signaling pathway plays a crucial role in the initiation and progression of various cancers, serving as reliable biomarkers and potential therapeutic targets. The canonical pathway is involved in cell survival and proliferation, while the noncanonical pathway regulates cell polarity and migration. In addition to its biological functions in development and homeostasis, the Wnt pathway is implicated in a range of pathological disorders, particularly cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Sha Zhu, Qifeng Bai, Lanqing Li, Tingyang Xu
Summary: Drug repositioning plays a significant role in drug development and machine learning methods can accelerate this process. This article focuses on the repurposing potential of type 2 diabetes mellitus drugs for various diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Oncology
Melissa F. Adasme, Daniele Parisi, Anastasia Sveshnikova, Michael Schroeder
Summary: Drug repositioning is a strategy to assign new therapeutic purposes to known drugs, with many success cases in the market and more in experimental stage. Understanding drug-target interactions is crucial, and the availability of target data is a limiting factor for realizing the full potential of structural drug repositioning.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Medicine, General & Internal
Alex M. Ebied, Hesham Elmariah, Rhonda M. Cooper-DeHoff
Summary: According to the FDA, 50 novel drugs were approved in 2021, with a majority being reviewed and approved through an expedited pathway, and over half of them approved for the treatment of rare diseases.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Alex M. Ebied, Hesham Elmariah, Rhonda M. Cooper-DeHoff
Summary: In 2022, the FDA approved 37 novel drugs, with 24 (65%) of them being reviewed and approved through an expedited pathway and 20 (54%) approved for rare disease treatment. This article provides a summary of the novel drugs approved by the FDA in 2022.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Meghana Korikani, Neeshat Fathima, Gouthami Nadiminti, Sravani Akula, Rama Krishna Kancha
Summary: This study aimed to understand the promiscuity of kinase inhibitors and explore potential drug repurposing opportunities. By analyzing biochemical IC50 values, fold-change of IC50 values for additional targets were calculated. Surprisingly, class II inhibitors showed higher promiscuity than class I inhibitors. The study also identified cancer types and sub-types with overexpressed kinase targets for drug repurposing, and predicted toxicity by profiling kinase expression in normal human tissues. Overall, this study provides kinase-specific opportunities for cancer treatment.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sang Ah Yi, Ki Hong Nam, Min Gyu Lee, Hwamok Oh, Jae Sung Noh, Jae Kyun Jeong, Sangwoo Kwak, Ye Ji Jeon, So Hee Kwon, Jaecheol Lee, Jeung-Whan Han
Summary: Eudesmin regulates stem cell fate determination by affecting PRC2 target genes, particularly influencing the Wnt signaling pathway and pluripotency. Treatment with eudesmin increases the occupancy of PRC2 components on the promoter region of DKK1, downregulating its transcription level, which in turn upregulates pluripotency markers Oct4, Sox2, and Nanog.
Review
Pharmacology & Pharmacy
Davide Benedetto Tiz, Luana Bagnoli, Ornelio Rosati, Francesca Marini, Claudio Santi, Luca Sancineto
Summary: This review describes recently FDA-approved drugs, many of which contain active moieties that have not been previously approved by the FDA. These drugs provide important new therapies for patients with multiple unmet diseases.
Review
Oncology
Yan-Qi Li, Zhi Zheng, Quan-Xing Liu, Xiao Lu, Dong Zhou, Jiao Zhang, Hong Zheng, Ji-Gang Dai
Summary: Drug repositioning is a strategy that repurposes existing clinical drugs for cancer treatment; recent studies focus on using antiparasitic drugs to target tumors, which can regulate tumor growth through multiple pathways and potentially improve tumor diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Alyson Haslam, Myung Sun Kim, Vinay Prasad
Summary: The study found that only a portion of drugs approved for genomic indications have demonstrated improvements in overall survival and progression-free survival in randomized studies. Drugs approved for BRAF V600 melanoma were more likely to show improvements in overall survival.
EUROPEAN JOURNAL OF CANCER
(2022)
Letter
Medicine, General & Internal
S. Sean Tu, Aaron S. Kesselheim, Kathrine Wetherbee, William B. Feldman
Summary: This study evaluates the frequency of continuation patents on brand-name drugs approved by the US Food and Drug Administration from 2000 to 2015.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Chemistry, Medicinal
Jian-Hui Zhao, Shuai Ma, Chao-Yuan Li, Hong-Chao Zhang, Li-Jie Zhao, Zi-Yan Zhang
Summary: Rheumatoid arthritis is a chronic autoimmune disease characterized by inflammation, neovascularization, inflammatory cell infiltration, and damage to cartilage and bone tissue. It causes physical pain, economic burden, and decreased quality of life, making it a leading cause of disability. Treatment for rheumatoid arthritis commonly includes drugs targeting Cyclooxygenase, janus kinase, and glucocorticoid receptor. This article provides a comprehensive review of 26 representative drugs for rheumatoid arthritis, aiming to facilitate the discovery of more effective treatments for this debilitating disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Lu Wang, Panyu Xu, Ying Xu, Ruiqin Cui, Yibo Yang, Zhao Zou, Hanqian Du, Chunyan Zhu, Guoxin Zhang, Tengfei Han, Na Lin
Summary: PLQT exhibits significant effects on key pathological links of osteoarthritis, including inhibiting chondrocyte apoptosis, extracellular matrix degradation, inflammation, and subchondral bone metabolism.
Review
Medicine, General & Internal
Alex M. Ebied, Hesham Elmariah, Rhonda M. Cooper-DeHoff
Summary: In 2020, the US Food and Drug Administration approved 53 novel drugs, with the majority being reviewed and approved through an expedited review pathway, and over half being approved for the treatment of rare diseases.
AMERICAN JOURNAL OF MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yonika Larasati, Cedric Boudou, Alexey Koval, Vladimir L. Katanaev
Summary: The Wnt signaling pathway plays a critical role in carcinogenesis, and FZD(7) receptor is important in various cancers. This review summarises the functions of FZD(7) in carcinogenesis and tissue homeostasis, discusses the development of drugs targeting FZD(7), and explores the challenges and possibilities in developing FZD(7)-selective antagonists.
DRUG DISCOVERY TODAY
(2022)
Article
Multidisciplinary Sciences
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Bruckner, Vladimir L. Katanaev, Jurgen Behrens, Dominic B. Bernkopf
Summary: This study finds that G alpha i2 can induce the condensation of conductin, leading to the degradation of β-catenin and inhibition of Wnt signaling, thus suppressing the growth of colorectal cancer. Colorectal cancer evades this inhibition by decreasing the expression of G alpha i2 and inactivating mutations, but the G alpha i2-activating drug guanabenz can reduce colorectal cancer growth.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Robin Huber, Laurence Marcourt, Alexey Koval, Sylvain Schnee, Davide Righi, Emilie Michellod, Vladimir L. Katanaev, Jean-Luc Wolfender, Katia Gindro, Emerson Ferreira Queiroz
Summary: A series of complex phenylpropanoid derivatives were obtained by chemoenzymatic biotransformation. These compounds showed anti-Wnt activity and have potential applications.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Neurosciences
Denis Silachev, Alexey Koval, Mikhail Savitsky, Guru Padmasola, Charles Quairiaux, Fabrizio Thorel, Vladimir L. Katanaev
Summary: This study establishes two mouse models of GNAO1 encephalopathy, which simulate different clinical manifestations of the disease and reveal it as a neurodevelopmental disorder. These models contribute to understanding the disease mechanism and developing future treatment approaches.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Antonina Klimenko, Robin Huber, Laurence Marcourt, Dmitry Tabakaev, Alexey Koval, Salim Sh. Dautov, Tatyana N. N. Dautova, Jean-Luc Wolfender, Rob Thew, Yuri Khotimchenko, Emerson Ferreira Queiroz, Vladimir L. L. Katanaev
Summary: Through metabolite analysis, we have identified five new chlorin compounds from Ophiura sarsii and O. ooplax, demonstrating their potential applications in photodynamic therapy.
Review
Biochemistry & Molecular Biology
Vladimir L. Katanaev, Alexey Baldin, Tatiana V. Denisenko, Denis N. Silachev, Anna E. Ivanova, Gennadiy T. Sukhikh, Lee Jia, Lev A. Ashrafyan
Summary: Wnt signaling plays multiple important roles in cancer, including primary transformation, tumor growth, and metastasis. It is not only crucial for cancer cell-intrinsic functions but also for cross-communication among different cell types in the tumor microenvironment. Various cell types, such as fibroblasts, macrophages, endothelial cells, and lymphocytes, use the Wnt language to communicate with cancer cells and each other, and these messages are essential for tumor progression and fate. Decoding this language will provide valuable insights into tumor biology and lead to novel therapeutic strategies.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vladimir L. Katanaev
Summary: Neuroscience and neurology research heavily relies on experimentation with rodents, but non-vertebrate models such as fruit flies have not been able to fully replace mice and rats in these studies. One reason is that existing methodologies for creating fruit fly models of neurological diseases do not accurately reflect the genetic conditions of the diseases. Therefore, the author argues for a systematic humanization approach, where the fruit fly orthologs of human disease genes are replaced with the human sequences. This approach would improve disease modeling and drug discovery in fruit flies.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Alexey Koval, Yonika A. Larasati, Mikhail Savitsky, Gonzalo P. Solis, Jean-Marc Good, Mathieu Quinodoz, Carlo Rivolta, Andrea Superti-Furga, Vladimir L. Katanaev
Summary: A study found a mutation in the GNAO1 gene associated with pediatric encephalopathies. A precision medicine workflow combining NGS diagnostics, molecular etiology analysis, and personalized drug discovery was used to study this mutation. The mutation was found to cause structural changes in the Gao protein, leading to aberrant biochemical functions and providing insights into the molecular etiology of this pathology.
Article
Microbiology
Alexey Koval, Jiabin Xu, Nathalia Williams, Mirco Schmolke, Karl-Heinz Krause, Vladimir L. Katanaev
Summary: Despite previous indications, pharmacological modulation of the Wnt pathway is not a promising strategy to control SARS-CoV-2 infection in lung epithelia.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Alexey Koval, Xin Zhang, Vladimir L. Katanaev
Summary: Intracellular signaling plays crucial roles in an organism's development and functioning, and dysregulation of signaling pathways can lead to various pathologies, including cancer. A key characteristic of cell signaling is channel capacity, which measures how much information can be reliably transmitted by a signaling system. In this study, we present improved methods to quantify the channel capacity of GPCR signaling in single cells, and we analyze the channel capacity of cancer cells for the first time. We find that different types of cancer cells exhibit decreased channel capacity in their GPCR signaling, supporting the hypothesis that cancer is an information disease. These findings have important implications for understanding cancer biology and discovering new anticancer drugs.
Meeting Abstract
Plant Sciences
R. Huber, L. Marcourt, A. Luscher, A. Koval, N. Hanna, J. Nitschke, S. Schnee, E. Michellod, T. Kohler, V. L. Katanaev, T. Soldati, J-L Wolfender, K. Gindro, Queiroz E. Ferreira
