Tiotropium in asthma: what is the evidence and how does it fit in?

Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial

(2016) Eckard Hamelmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial

(2016) Pierluigi Paggiaro et al.   Journal of Allergy and Clinical Immunology-In Practice

The prevalence of severe refractory asthma

(2015) Pieter-Paul W. Hekking et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized, three-period crossover study of umeclidinium as monotherapy in adult patients with asthma

(2015) Laurie A. Lee et al.   RESPIRATORY MEDICINE

Once-daily tiotropium Respimat® 5 μg is an efficacious 24-h bronchodilator in adults with symptomatic asthma

(2015) Wolfgang Timmer et al.   RESPIRATORY MEDICINE

Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling

(2015) Loes E.M. Kistemaker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials

(2015) Huib A M Kerstjens et al.   Lancet Respiratory Medicine

Long-Term Once-Daily Tiotropium Respimat® Is Well Tolerated and Maintains Efficacy over 52 Weeks in Patients with Symptomatic Asthma in Japan: A Randomised, Placebo-Controlled Study

(2015) Ken Ohta et al.   PLoS One

Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: A randomised dose-ranging study

(2014) Christian Vogelberg et al.   RESPIRATORY MEDICINE

Tiotropium Respimat® in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma

(2014) Kai-Michael Beeh et al.   RESPIRATORY RESEARCH

Cost Effectiveness of Tiotropium in Patients with Asthma Poorly Controlled on Inhaled Glucocorticosteroids and Long-Acting β-Agonists

(2014) Jenny Willson et al.   Applied Health Economics and Health Policy

Predictors of response to tiotropium versus salmeterol in asthmatic adults

(2013) Stephen P. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe asthma: future treatments

(2012) P. M. O'Byrne et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The non-neuronal cholinergic system: Basic science, therapeutic implications and new perspectives

(2012) Sergei A. Grando et al.   LIFE SCIENCES

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

(2012) Huib A.M. Kerstjens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of anticholinergic drugs in asthma

(2012) Federica Novelli et al.   Expert Review of Respiratory Medicine

Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma

(2011) Eric D. Bateman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current Control and Future Risk in Asthma Management

(2011) Erika J Sims et al.   Allergy Asthma & Immunology Research

Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD

(2010) Bart C Moulton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma

(2010) S. Ohta et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Overall asthma control: The relationship between current control and future risk

(2010) Eric D. Bateman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Status of Asthma Control in Pediatric Primary Care: Results from the Pediatric Asthma Control Characteristics and Prevalence Survey Study (ACCESS)

(2010) Andrew H. Liu et al.   JOURNAL OF PEDIATRICS

The FDA and Safe Use of Long-Acting Beta-Agonists in the Treatment of Asthma

(2010) Badrul A. Chowdhury et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

(2010) Stephen P. Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD

(2010) L. Wollin et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)

(2010) E. H. Bel et al.   THORAX

Achieving asthma control in practice: Understanding the reasons for poor control

(2008) John Haughney et al.   RESPIRATORY MEDICINE