Article
Pharmacology & Pharmacy
Ru Chen, Juan Wu, Chang Lu, Ting Yan, Yu Qian, Huiqing Shen, Yujing Zhao, Jianzhen Wang, Pengzhou Kong, Xinri Zhang
Summary: CA extracted from cinnamon has shown antiviral and anti-tumor effects, including inhibiting proliferation, invasion, and migration, inducing apoptosis, and suppressing tumor growth in NSCLC. Through the ceRNA network, key genes SOCS1, BTG2, and BTK were identified as playing essential roles in CA against NSCLC.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Tanchun Cheng, Shouguo Huang
Summary: Metastasis in cervical cancer is not well understood, with non-coding RNAs playing diverse roles in this process. Dysregulation of miRNAs, lncRNAs, and circRNAs is associated with metastasis. They regulate metastasis by influencing metastasis-related genes, epithelial-mesenchymal transition, signaling pathways, and interactions with the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yikun Xu, Binshu Chai, Xianyi Wang, Zong Wu, Zhitao Gu, Xiaomin Liu, Yiqi Zhao, Tangbing Chen, Zhongliang Ma, Qiangling Sun
Summary: In this study, low expression of miR-199a-5p in NSCLC sera samples was found, and miR-199a-5p was demonstrated to suppress cell proliferation, migration, and cell cycle arrest in NSCLC cell lines by targeting SLC2A1. This study suggests that miR-199a-5p can inhibit glucose metabolism in NSCLC and provides a novel approach for clinical treatments of NSCLC.
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Xin Yu, Xueqing Zhu, Hongjun Xu, Linfeng Li
Summary: Keloids are pathological wound healing conditions that significantly impact patients by causing psychosocial and functional distress. The main pathophysiology of keloid is the deposition of extracellular matrix (ECM) and proliferation of human fibroblasts. Recent research has shown that deregulated long non-coding RNAs (LncRNAs) contribute to the formation of keloids. Exploring lncRNA-based methods holds promise as new effective therapies against keloids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Omid Reza Tamtaji, Maryam Derakhshan, Fatemeh Zahra Rashidi Noshabad, Javad Razaviyan, Razie Hadavi, Hamed Jafarpour, Ameneh Jafari, Ali Rajabi, Michael R. Hamblin, Mahmood Khaksary Mahabady, Mohammad Taghizadieh, Hamed Mirzaei
Summary: Brain tumor is a major global disease that causes significant mortality, and non-coding RNAs have been found to play important roles in the development and apoptosis of brain tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bodhisattwa Banerjee, Debaprasad Koner, David Karasik, Nirmalendu Saha
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in regulating neuronal development and differentiation pathways in the zebrafish brain regions under hypoxia. Differential expression of certain lncRNAs and mRNAs under hypoxia suggests their potential involvement in the pathogenesis of Alzheimer's disease (AD).
Article
Oncology
Samarth Kansara, Agrata Singh, Abhishesh Kumar Badal, Reshma Rani, Prakash Baligar, Manoj Garg, Amit Kumar Pandey
Summary: Altered energy metabolism is a key characteristic of tumorigenesis, and non-coding RNAs (ncRNAs) play a significant role in regulating glucose metabolism in human cancers. In this review, the aberrant expression of glucose metabolic pathways in breast cancer is outlined, and the potential applications of ncRNAs in regulating energy pathways, as well as their importance in prognosis, diagnosis, and future therapeutics for breast carcinoma, are discussed.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Cell Biology
Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: Non-coding RNAs play a crucial role in regulating angiogenesis in glioblastoma, affecting gene transcription and the expression of angiogenesis-inducing molecules through various mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yueyue Wang, Qian Liu, Fengchao Wang
Summary: Chemoresistance is a common issue in various types of tumors, leading to cancer relapse. Non-coding RNAs, especially those carried by exosomes, play crucial roles in mediating chemoresistance and cell-to-cell communication in cancer.
Article
Biotechnology & Applied Microbiology
Miao Da, Hao Jiang, Yangyang Xie, Weili Jin, Shuwen Han
Summary: Exosomal lncRNAs play a crucial role in regulating cancer progression, angiogenesis, and chemotherapy resistance, with potential applications in cancer diagnosis, treatment, and prognosis. Exosomal lncRNAs can transmit different phenotypic patterns to neighboring cells, serving as a new medium for cancer behavior.
ONCOTARGETS AND THERAPY
(2021)
Review
Medicine, Research & Experimental
Jicheng Wang, Yanshan Sun, Jianyong Liu, Bo Yang, Tengyun Wang, Zhen Zhang, Xin Jiang, Yongzhi Guo, Yangyang Zhang
Summary: OA is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation, causing chronic pain and joint activity disorder. Recent studies on lncRNA's role in the pathogenesis of OA provide valuable information for the prevention, diagnosis, and treatment of this condition.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yu Yan, Danzhu Wu, Liyuan Yang, Jinming Han, Yinglong Liu, Peng Dong, Jing Wu, Xinshuang Yu
Summary: This review summarizes the roles of long non-coding RNAs (lncRNAs) in pancreatic cancer, including their effects on occurrence, development, therapeutic resistance, and potential clinical implications. Understanding the functions and regulatory mechanisms of lncRNAs in pancreatic cancer is of great significance for researchers in developing novel therapeutic strategies.
ADVANCED THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Daniele Lettieri-Barbato, Katia Aquilano, Carolina Punziano, Giuseppina Minopoli, Raffaella Faraonio
Summary: Cell senescence plays critical roles in various aspects of organism life, including tissue development, homeostasis, tumor suppression, and aging-related diseases. Oxidative stress, caused by inadequate detoxification of reactive oxygen/nitrogen species, is a major driver of senescence. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, are important regulators of cellular processes, including oxidative stress responses and senescence.
Article
Chemistry, Multidisciplinary
Hong Yu, Hong-ying Gao, Hua Guo, Gui-zhen Wang, Yi-qing Yang, Qian Hu, Li-jun Liang, Qun Zhao, Da-wei Xie, Yu Rao, Guang-biao Zhou
Summary: RYL-687 inhibits non-small cell lung cancer cells by upregulating p53, which is achieved by inducing reactive oxygen species and upregulating NQO1 to protect p53 from degradation. Targeting NQO1 is a rational strategy to reactivate p53 and RYL-687 has therapeutic potentials in NSCLCs with wild type p53.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Chemistry, Medicinal
Lichuan Wu, Ke Ye, Sheng Jiang, Guangbiao Zhou
Summary: Around 19.3 million new cancer cases and almost 10.0 million cancer deaths occur worldwide each year. Attention has recently been focused on the ocean as a potential source of novel drugs to fight against malignant neoplasms. Marine compounds have shown promising anticancer activity, but few drugs have been approved for specific cancer treatments by the U.S. Food and Drug Administration.
Article
Oncology
Chen Zhang, Jiandong Zhang, Fan Liang, Han Guo, Sanhui Gao, Fuying Yang, Hua Guo, Guizhen Wang, Wei Wang, Guangbiao Zhou
Summary: Siglec10 is a member of innate immune checkpoints that inhibits immune cell activation by interacting with CD24 on tumor cells. Expression of Siglec10 was found to be altered in various cancers, particularly upregulated in kidney renal clear cell carcinoma (KIRC) with negative prognosis correlation. It may play an oncogenic role in KIRC by suppressing immune cell activation and interacting with CD24.
FRONTIERS OF MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Li-jun Liang, Di Wang, Hong Yu, Jun Wang, Hui Zhang, Bei-bei Sun, Fu-ying Yang, Zheng Wang, Da-wei Xie, Rui-E Feng, Kai-feng Xu, Gui-zhen Wang, Guang-biao Zhou
Summary: In this study, the researchers evaluated the transcription factors that regulate ACE2 expression and identified 24 potential regulators, with Stat3 being the most significant one. They also found that a compound called 6-OAP could effectively inhibit ACE2 expression and reduce IL-6 production. Moreover, 6-OAP was found to inhibit the entry of SARS-CoV-2 into target cells.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
San-Hui Gao, Gui-Zhen Wang, Li-Peng Wang, Lin Feng, Yong-Chun Zhou, Xian-Jun Yu, Fan Liang, Fu-Ying Yang, Zheng Wang, Bei-Bei Sun, Di Wang, Li-Jun Liang, Da-Wei Xie, Song Zhao, Hai-Ping Feng, Xueqing Li, Keqin Kathy Li, Tie-Shan Tang, Yun-Chao Huang, Shi-Qiang Wang, Guang-Biao Zhou
Summary: CACNA1E gene mutations are associated with non-small cell lung cancer, with high expression correlating with poor prognosis. Overexpression or mutation of CACNA1E promotes NSCLC cell proliferation, while gene silencing inhibits proliferation, suggesting that this protein is essential for NSCLC cell proliferation.
Correction
Multidisciplinary Sciences
Gui-Zhen Wang, Li Zhang, Xin-Chun Zhao, San-Hui Gao, Li-Wei Qu, Hong Yu, Wen-Feng Fang, Yong-Chun Zhou, Fan Liang, Chen Zhang, Yun-Chao Huang, Zhihua Liu, Yang-Xin Fu, Guang-Biao Zhou
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Peng-Fei Tian, Yu-Chen Ma, Dong-Sheng Yue, Fan Liang, Chen-Guang Li, Chen Chen, Hua Zhang, Xiao-Yan Sun, Wu-Hao Huang, Zhen-Fa Zhang, Guang-Biao Zhou, Gui-Zhen Wang, Bin Zhang, Chang-Li Wang
Summary: The study suggests that CXCL14 could serve as a potential diagnostic and prognostic biomarker in patients with lung cancer, as its expression is significantly associated with advanced disease stage, recurrence, and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Plant Sciences
Yong-Qiang Liu, Guang-Biao Zhou
Summary: This review provides a comprehensive summary of the anticancer properties exhibited by active components of Centipeda minima (C. minima). It discusses the anticancer potential of C. minima extracts and the identification of active components. Sesquiterpene lactones, such as 6-O-angeloylplenolin (6-OAP) and arnicolide D, have been found to have similar structures and anticancer mechanisms. Clinical trials have assessed the potential of these components in treating vertex balding, alopecia areata, and glioma. Therefore, a better understanding of the underlying anticancer mechanisms and further clinical trials are important for the development of novel anticancer drugs.
Correction
Plant Sciences
Yong-Qiang Liu, Guang-Biao Zhou
Editorial Material
Cell Biology
Si-Chong Han, Gui-Zhen Wang, Guang-Biao Zhou
Summary: This study by Swanton et al.(1) reveals that exposure to PM2.5 is linked to an increased incidence of EGFR/KRAS-driven lung cancer. PM2.5 enhances the function and tumorigenic activity of pre-mutated alveolar type II cell progenitors through interleukin-1 beta secreted by interstitial macrophages, offering potential strategies for cancer prevention.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Dawei Xie, Zheng Wang, Beibei Sun, Liwei Qu, Musheng Zeng, Lin Feng, Mingzhou Guo, Guizhen Wang, Jihui Hao, Guangbiao Zhou
Summary: Based on the analysis of The Cancer Genome Atlas datasets, FAK(6/7) was found to be strongly associated with neuroendocrine neoplasms (NENs), suggesting its potential as a biomarker and therapeutic target for NENs.
FRONTIERS OF MEDICINE
(2023)
Letter
Biochemistry & Molecular Biology
Si-Chong Han, Gui-Zhen Wang, Ya-Ning Yang, Wen-Feng Fang, Bei-Bei Sun, Jian-Dong Zhang, Hua-Qiang Zhou, Li Zhang, Yan Wang, Guang-Biao Zhou
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Integrative & Complementary Medicine
Qun Zhao, Mengyuan Feng, Shu Jin, Xiaobo Liu, Shengbao Li, Jian Guo, Xinran Cheng, Guangbiao Zhou, Xianjun Yu
Summary: The natural-product macrolide, 10,11-Dehydrocurvularin (DCV), inhibits NLRP3 inflammasome activation, reducing IL-1 beta secretion and caspase-1 activation without affecting NLRC4 and AIM2 inflammasomes. DCV disrupts the interaction between NEK7 and NLRP3, inhibiting NLRP3 inflammasome activation. Furthermore, DCV ameliorates inflammation in vivo by inhibiting the NLRP3 inflammasome.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Fan Liang, Gui-Zhen Wang, Yan Wang, Ya-Ning Yang, Zhe-Sheng Wen, Dong-Ni Chen, Wen-Feng Fang, Bin Zhang, Lu Yang, Chen Zhang, Si-Chong Han, Fu-Ying Yang, Di Wang, Li-Jun Liang, Zheng Wang, Yong Zhao, Chang-Li Wang, Li Zhang, Guang-Biao Zhou
Summary: Tobacco smoke induces IDO1 to promote carcinogenesis. Smokers with lower IDO1 levels respond better to anti-PD1 antibody treatment, while smokers with higher IDO1 levels may benefit from IDO1 inhibitors in combination with anti-PD1 antibodies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yenan Fu, Xi Zhang, Xiao Liu, Peng Wang, Wenhui Chu, Wei Zhao, Yunling Wang, Guangbiao Zhou, Yu Yu, Hongquan Zhang
Summary: The DNMT1-PAS1-PH20 axis plays an important role in controlling breast cancer growth and metastasis. PAS1 suppresses PH20 expression by recruiting SUV39H1 for methylation, leading to its silencing. Targeting this axis could be a potential therapeutic strategy for breast cancer.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
