Article
Biochemistry & Molecular Biology
Kevin Pacheco-Barrios, Danielle Carolina Pimenta, Anne Victorio Pessotto, Felipe Fregni
Summary: The clinical correlates of transcranial magnetic stimulation (TMS) measures, such as resting motor threshold (MT), motor-evoked potential (MEP), short intracortical inhibition (SICI), and intracortical facilitation (ICF), in fibromyalgia syndrome (FMS) patients were investigated. It was found that SICI was associated with sleepiness, comorbidities, disease duration, and anxiety, while ICF showed a positive correlation with pain levels and a negative correlation with body mass index (BMI). These findings suggest that SICI and ICF metrics may serve as potential phenotyping biomarkers in FMS.
Article
Behavioral Sciences
Qian Ding, Huiting Cai, Manfeng Wu, Guiyuan Cai, Hongying Chen, Wanqi Li, Tuo Lin, Yinghua Jing, Tifei Yuan, Guangqing Xu, Yue Lan
Summary: This study systematically investigated the relationship between resting-state intracortical inhibition or facilitation and inhibitory control, finding a positive correlation between short intracortical facilitation and poorer inhibitory control. This suggests that short intracortical facilitation may serve as a potential physiological biomarker for motor-inhibitory control and have clinical implications for disorders associated with inhibitory control deficits.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Engineering, Electrical & Electronic
Sana Ullah, Hyoungsuk Yoo
Summary: This article introduces rectangular and circular intravascular receive-only microcoils for blood-vessel and brain-aneurysm imaging, with advantages of wider bandwidth, high signal-to-noise ratio, and improved vessel imaging compared to state-of-the-art microcoils. The open interiors of the proposed microcoils allow uninterrupted blood flow during MRI scanning and reduce motion artifacts. Simulation results show significant enhancements in reception efficiency and B-1 field strengths in the region of interest, with high sensitivity to blood signals and selective imaging of arterial walls achieved by the proposed microcoils.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2021)
Article
Engineering, Biomedical
Kyeong Jae Lee, Byungwook Park, Jae-Won Jang, Sohee Kim
Summary: Magnetic stimulation using small implantable coils and low current is a feasible alternative to transcranial magnetic stimulation (TMS) and electric stimulation with implantable devices. It improves stimulation selectivity and eliminates the need for metal exposure to tissue.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Sahar Elyahoodayan, Wenxuan Jiang, Curtis D. Lee, Xiecheng Shao, Gregory Weiland, John J. Whalen, Artin Petrossians, Dong Song
Summary: This study demonstrated the capability of recording single units and evoked potentials through high-resolution microelectrodes coated with Pt-Ir, showing higher signal-to-noise ratios and lower voltages compared to uncoated electrodes. The improved performance of the coated electrodes led to lower energy consumptions and enabled electrochemically safe stimulation above 5 μA. This work provides a powerful tool for monitoring and manipulating neural circuits at the single neuron level by stimulating and recording single unit activities from the same microelectrode.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ke Zeng, Ghazaleh Darmani, Anton Fomenko, Xue Xia, Stephanie Tran, Jean-Francois Nankoo, Yazan Shamli Oghli, Yanqiu Wang, Andres M. Lozano, Robert Chen
Summary: Transcranial ultrasound stimulation (TUS) has been shown to effectively induce cortical plasticity in human subjects, with the potential for neuromodulation treatment for neurological and psychiatric disorders, as well as advancing neuroscience research. This study demonstrated the efficacy of TUS in increasing corticospinal excitability and modulating intracortical inhibition and facilitation in the motor cortex.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Computer Science, Information Systems
Tan Pan, Yuanwen Zou
Summary: The development of neural implantable systems has advanced neurosurgery research and clinical practice. However, the limitations of traditional tethered neural implants have driven the need for untethered, wireless, and controllable neural stimulation. In this study, a wirelessly powered stimulator using magnetically coupled resonant wireless power transfer (MCR-WPT) technology was designed and manufactured for electrical stimulation experiments in nerve repair. The stimulator demonstrated low-frequency, safe, and controllable wireless stimulation capabilities through experimental tests.
Review
Nanoscience & Nanotechnology
Renata Saha, Kai Wu, Robert P. Bloom, Shuang Liang, Denis Tonini, Jian-Ping Wang
Summary: This article reviews the use of electrical probes and arrays in the treatment of neurodegenerative, sensory, and cardiovascular diseases. It discusses the limitations of current techniques and introduces micromagnetic stimulation as a promising alternative. The review also highlights the features and potential applications of magnetic neurostimulators, including microcoils, spintronic nanodevices, and magnetic nanoparticles.
Article
Clinical Neurology
Martin Syvertsen Mykland, Martin Uglem, Jan Petter Neverdahl, Lise Rystad Oie, Tore Wergeland Meisingset, David W. Dodick, Erling Tronvik, Morten Engstrom, Trond Sand, Petter Moe Omland
Summary: This study investigates the mechanisms of insufficient sleep in migraine by using transcranial magnetic stimulation. It is found that sleep restriction reduces GABAergic cortical inhibition during the interictal period in individuals with migraine, particularly in non-sleep related migraine and migraine with aura. The sleep restriction effect is associated with hypersensitivity symptoms such as photophobia, while the overall silent period is associated with premonitory dopaminergic symptoms such as yawning. These findings suggest that sleep related mechanisms may affect the pathophysiology of migraine and differentiate between migraine subgroups.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Zhongfei Bai, Jack Jiaqi Zhang, Kenneth N. K. Fong
Summary: This study investigated the immediate effects of intermittent theta burst stimulation (iTBS) on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke. The results showed that iTBS enhanced the amplitude of ipsilesional motor evoked potentials (MEPs) and P30 of TMS-evoked potentials located at the ipsilesional primary motor cortex (M1), but it did not have modulatory effects on intracortical inhibition or TMS-related oscillations and neural connectivity.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Review
Psychiatry
Parmis Fatih, M. Utku Kucuker, Jennifer L. Vande Voort, Deniz Doruk Camsari, Faranak Farzan, Paul E. Croarkin
Summary: Based on 113 articles, it is suggested that LICI may serve as a biomarker of GABA(B) functioning, but more rigorous research is required. The existing LICI literature shows methodological heterogeneity and inconsistencies in findings, which are also non-specific to diseases. Future studies should address these weaknesses and focus on high-quality test-retest reliability.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Alexandre Caux-Dedeystere, Etienne Allart, Pierre Morel, Alexandre Kreisler, Philippe Derambure, Herve Devanne
Summary: In patients with writer's cramp (WC), alterations in GABAergic inhibitory mechanisms result in longer duration of LICI and delayed LCD, affecting the activity of primary motor cortex inhibitory and excitatory circuits controlling hand muscles. This study highlights the impact of these changes on involuntary muscle contractions while writing and the potential therapeutic targets for WC.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Substance Abuse
Yuyu Song, Yanling Pi, Xiaoying Tan, Xue Xia, Yu Liu, Jian Zhang
Summary: By conducting three transcranial magnetic stimulation (TMS) experiments, the researchers measured the modulatory mechanisms in the primary motor cortex (M1) of smokers when they actively approached or avoided smoking-related cues. The results showed that smokers had faster reaction times, increased excitability of corticospinal pathways and intracortical facilitation effects when approaching smoking-related cues. On the other hand, they exhibited stronger short-interval intracortical inhibition effects when avoiding these cues.
Article
Neurosciences
Arturo Nuara, Maria Chiara Bazzini, Pasquale Cardellicchio, Emilia Scalona, Doriana De Marco, Giacomo Rizzolatti, Maddalena Fabbri-Destro, Pietro Avanzini
Summary: Observation of others' actions is crucial for motor skill acquisition and can induce changes in motor cortex excitability. Action Observation Training (AOT) improves motor performance, and the extent of improvement is predicted by the modulation of corticospinal excitability and intracortical inhibition during action observation.
Review
Nanoscience & Nanotechnology
Hoa Thanh Le, Rubaiyet I. Haque, Ziwei Ouyang, Seung Woo Lee, Shelley I. Fried, Ding Zhao, Min Qiu, Anpan Han
Summary: This review provides a comprehensive overview of state-of-the-art MEMS technologies for inductor fabrication, presents recent advances in 3D additive fabrication technologies, and discusses the challenges and opportunities of MEMS inductors for two emerging applications, namely, integrated power electronics and neurotechnologies.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Biochemical Research Methods
Marie Palma, Mehrdad Khoshnevis, Marie Lion, Cyril Zenga, Samy Kefs, Florian Fallegger, Giuseppe Schiavone, Isabelle Gabelle Flandin, Stephanie Lacour, Blaise Yvert
Summary: The study demonstrates the safe implantation of soft ECoG grids using conventional craniotomy in minipigs younger than 5 months, revealing cortical dynamics underlying vocal production. Activation of the motor and premotor cortex around the onset of grunting in behaving animals indicates minipigs as a potential large animal model for studying the cortical bases of vocal production.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Biology
Jae-Ik Lee, Richard Seist, Stephen McInturff, Daniel J. Lee, M. Christian Brown, Konstantina M. Stankovic, Shelley Fried
Summary: Cochlear implants (CIs) provide sound and speech sensations for patients with severe to profound hearing loss. However, they have limited effectiveness in utilizing complex neural coding such as appreciating music. Recent research suggests that magnetic stimulation from micro-coils can improve the spectral resolution of CIs. Experimental results show that activation with micro-coils is about 60% narrower compared to electric stimulation and similar to acoustic stimulation, supporting the idea that magnetic micro-coil CIs can produce a larger number of independent spectral channels and potentially improve auditory outcomes.
Article
Neurosciences
Beatrice Barra, Sara Conti, Matthew G. Perich, Katie Zhuang, Giuseppe Schiavone, Florian Fallegger, Katia Galan, Nicholas D. James, Quentin Barraud, Maude Delacombaz, Melanie Kaeser, Eric M. Rouiller, Tomislav Milekovic, Stephanie Lacour, Jocelyne Bloch, Gregoire Courtine, Marco Capogrosso
Summary: This study focuses on restoring arm and hand control in paralyzed individuals using spinal cord stimulation. By stimulating specific spinal segments, sustained arm movements were produced, allowing monkeys with paralysis to regain the ability to reach and grasp within a few days after injury.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Seung Woo Lee, Shelley I. Fried
Summary: This study demonstrates that magnetic stimulation of the visual cortex using microcoils can induce localized activation in the secondary visual cortex. Compared to conventional electrodes, microcoils better confine activation and produce more precise and sustained activation in higher visual centers.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Neurosciences
Morgan E. Urdaneta, Nicolas G. Kunigk, Seth Currlin, Francisco Delgado, Shelley I. Fried, Kevin J. Otto
Summary: Intracortical microstimulation (ICMS) can restore sensory function in paralyzed patients. This study investigates the stability of ICMS and the impact of cortical layers on its performance. The results demonstrate that ICMS sensitivity and long-term performance are layer dependent, with different cortical layers exhibiting varying levels of foreign body response (FBR) and astrocytic glial scar.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Arda Uran, Kerim Ture, Cosimo Aprile, Alix Trouillet, Florian Fallegger, Emilie C. M. Revol, Azita Emami, Stephanie P. Lacour, Catherine Dehollain, Yusuf Leblebici, Volkan Cevher
Summary: This article presents a neural recording system-on-chip that achieves high resource and wireless bandwidth efficiency. The chip is able to compress and reduce the data rate of raw neural signals while maintaining good classification performance, enabling simultaneous recording from a large number of channels.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2022)
Article
Engineering, Biomedical
TaeKen Kim, Herve Kadji, Andrew J. Whalen, Arian Ashourvan, Eugene Freeman, Shelley Fried, Srinivas Tadigadapa, Steven J. Schiff
Summary: This study found that electrical and magnetic stimulation of the brain generates small thermal effects, resulting in consistent transient suppression and excitation of neurons. Understanding the underlying biophysics and incorporating thermal effects into models can lead to more accurate modulation of neuronal activity.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Biophysics
Xiyuan Liu, Andrew J. Whalen, Kayeon Kim, Changsi Cai, Martin Lauritzen, Nicolas Bertram, Bingdong Chang, Tianbo Yu, Anpan Han, Seung Woo, Shelley I. Fried
Summary: Micro-coil magnetic stimulation of brain tissue poses challenges for MEMS micro-coil probe fabrication, including low coil resistance, low leak current, and adaptive process technology. We propose a fabrication process that utilizes multilayer resist lift-off, encapsulation of micro-coil Al wires, and a combination of DRIE process and maskless photolithography. The resulting probes are validated in vivo using mice and show improvements compared to previous work.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Robotics
Sukho Song, Florian Fallegger, Alix Trouillet, Kyungjin Kim, Stephanie P. Lacour
Summary: This study presents a scalable technique for fabricating large-area soft robotic electrode arrays that can be deployed on the cortex. The deployable system consists of up to six prefolded soft legs that are placed subdurally on the cortex using a pressurized solution. Each leg contains soft, microfabricated electrodes and strain sensors for real-time deployment monitoring. A proof-of-concept surgery on a minipig successfully demonstrated the deployment of a soft robotic electrode array on the cortex to record sensory cortical activity. This technology has promising applications in minimally invasive cortical surgery and neurological disorders.
Article
Engineering, Biomedical
Andrew J. Whalen, Shelley Fried
Summary: Micro magnetic stimulation of the brain via implantable micro-coils is a promising technology for neuromodulation, but careful consideration of the thermodynamic profile is necessary. This study used thermocouples and finite element modeling to examine the thermal gradients generated by bent wire micro-coils during stimulation. By switching coil wire material, the thermal impact of stimulation was significantly reduced below the safety limit.
JOURNAL OF NEURAL ENGINEERING
(2023)
Meeting Abstract
Ophthalmology
Yanjinsuren Otgondemberel, Hyeonhee Roh, Shelley Fried, Maesoon Im
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Edward C. Szoka, Jesse C. Werth, Sunwoo Lee, Jae-Ik Lee, Alejandro J. Cortese, Thomas A. Cleland, Shelley Fried, Alyosha Molnar
Summary: Micro-coil based magnetic stimulation is an effective form of neural modulation that offers spatially asymmetric electric fields for neuron orientation-based selectivity without direct contact with biological tissue. However, traditional micro-coil based neural probes lack reconfigurable hardware, leading to fixed stimulation sites post-insertion.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)