Editorial Material
Cell Biology
Michael Way, Sharon Ahmad
JOURNAL OF CELL SCIENCE
(2021)
Editorial Material
Cell Biology
Michael Way
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Chiara Galloni, Davide Carra, Jasmine V. G. Abella, Svend Kjaer, Pavithra Singaravelu, David J. Barry, Naoko Kogata, Christophe Guerin, Laurent Blanchoin, Michael Way
Summary: The study found that Arp3 and Arp3B isocomplexes both efficiently promote actin assembly but generate branched actin networks with different disassembly rates, with Arp3B dissociating significantly faster than Arp3. This difference is due to the oxidation of Arp3B by MICAL2, which is recruited to the actin network by coronin 1C, and together with cortactin, they promote the disassembly of branched actin networks.
JOURNAL OF CELL BIOLOGY
(2021)
Editorial Material
Cell Biology
Michael Way, Sharon Ahmad
JOURNAL OF CELL SCIENCE
(2021)
Editorial Material
Cell Biology
Michael Way, Sharon Ahmad
JOURNAL OF CELL SCIENCE
(2022)
Editorial Material
Cell Biology
Sharon Ahmad, Michael Way
JOURNAL OF CELL SCIENCE
(2022)
Article
Biology
Angika Basant, Michael Way
Summary: The positioning of pTyr motifs plays a crucial role in the signal cascade driving the movement and spread of Vaccinia virus. Only specific spatial arrangements of pTyr motifs result in the recruitment of N-WASP and Arp2/3 complex-mediated actin polymerization, indicating that the relative position of pTyr adaptor binding sites is optimized for signal output.
Article
Cell Biology
Amadeus Xu, Angika Basant, Sibylle Schleich, Timothy P. Newsome, Michael Way
Summary: The study reveals that intracellular mature viruses (IMVs) and intracellular enveloped viruses (IEVs) can undergo microtubule-based motility and recruit the kinesin-1 motor protein for transport. IMVs are the first and most abundant infectious form of vaccinia virus during its replication cycle. These findings provide insights into the transport mechanism of the virus.
JOURNAL OF CELL SCIENCE
(2023)
Editorial Material
Cell Biology
Michael Way
JOURNAL OF CELL SCIENCE
(2022)
Editorial Material
Cell Biology
Michael Way
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Luyan Cao, Foad Ghasemi, Michael Way, Antoine Jegou, Guillaume Romet-Lemonne
Summary: Activation of the Arp2/3 complex by actin nucleation-promoting factors leads to the formation of branching actin filaments, while direct nucleation of linear actin filaments is induced by SPIN90-Arp2/3. Interestingly, the VCA motifs of certain proteins destabilize existing branches and linear filament ends. However, branch stabilizer cortactin and destabilizer GMF have similar effects on SPIN90-activated Arp2/3. These findings highlight the importance of understanding the similarities and differences between the two mechanisms in regulating actin cytoskeleton dynamics, as well as the differential responses of branched and linear filaments to aging and mechanical stress.
Editorial Material
Cell Biology
Michael Way
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Miguel Hernandez-Gonzalez, Thomas Calcraft, Andrea Nans, Peter B. Rosenthal, Michael Way
Summary: A new pseudohexagonal lattice made of trimeric pillars forms inside immature vaccinia virus particles during maturation, leading to the transition from non-infectious spherical virions to infectious brick-shaped virions. The viral membrane becomes corrugated as it adapts to the newly formed viral core without membrane removal.
Article
Cell Biology
Elena Sindram, Andres Caballero-Oteyza, Naoko Kogata, Shaina Chor Mei Huang, Zahra Alizadeh, Laura Gamez-Diaz, Mohammad Reza Fazlollhi, Xiao Peng, Bodo Grimbacher, Michael Way, Michele Proietti
Summary: The Arp2/3 complex is essential for the formation of branched actin networks. We identified a frameshift variant in the ARPC5 gene in a child with recurrent infections and birth defects. Loss of ARPC5 affects actin cytoskeleton organization and leads to developmental defects in mice. ARPC5 should be considered as a candidate gene for early-onset immunodeficiency.
DISEASE MODELS & MECHANISMS
(2023)
Editorial Material
Cell Biology
Michael Way
JOURNAL OF CELL SCIENCE
(2023)