Letter
Immunology
John B. Fournier, Lucas S. Blanton, Nivison Nery Jr, Elsio A. Wunder Jr, Federico Costa, Mitermayer G. Reis, Guilherme S. Ribeiro, David H. Walker, Albert I. Ko
Summary: Enhanced acute febrile illness surveillance in an urban slum community in Salvador, Brazil revealed that rickettsial infection accounted for 3.5% of urgent care visits for acute fever, suggesting it might be an underrecognized, treatable cause of acute febrile illness in impoverished urban populations in Brazil.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Xudong Ma, Annoor Awadasseid, Kang Zhou, Xiao Wang, Chenfeng Shen, Xiaoyin Zhao, Mei Cheng, Wen Zhang
Summary: The study demonstrates that compound 13d induces autophagy and apoptosis in gastric cancer cells, while also promoting telomere dysfunction and DNA damage by blocking the Akt/m-TOR signaling pathway. This compound effectively inhibits proliferation, migration, and invasion of tumor cells.
Article
Immunology
Liyun Liu, Ling Zhang, Haijian Zhou, Min Yuan, Dalong Hu, Yonglu Wang, Hui Sun, Jianguo Xu, Ruiting Lan
Summary: This prospective study investigated molecular characteristics and antimicrobial susceptibility patterns of Citrobacter spp. isolates from extraintestinal infections. The results showed a diverse range of Citrobacter isolates causing extraintestinal infections and a high prevalence of multidrug resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Helge Waldum, Reidar Fossmark
Summary: Despite a decrease in prevalence over the past few decades, gastric cancer remains a significant global cause of death, with Helicobacter pylori infection reduction being a key factor. The carcinogenic effects of H. pylori are likely due to hypergastrinemia and autoimmune gastritis, while long-term use of proton pump inhibitors may also predispose individuals to ECL cell neoplasia. Additionally, gastric polyps, although generally low in malignant potential, can still pose a cancer risk and share some common risk factors and mechanisms with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Wenchang Yang, Xin Chen, Peng Zhang, Chengguo Li, Weizhen Liu, Zheng Wang, Yuping Yin, Kaixiong Tao
Summary: This study found that a PCT value less than 2.03 ng/mL on postoperative day 3 in patients undergoing GC surgery is an excellent negative predictor of IAIs, ensuring safe early discharge.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Infectious Diseases
Rosalino Vazquez-Lopez, Tanya Hernandez-Martinez, Selene Ivonne Larios-Fernandez, Celia Pina-Leyva, Manuel Lara-Lozano, Tayde Guerrero-Gonzalez, Javier Martinez-Bautista, Eduardo Gomez-Conde, Juan Antonio Gonzalez-Barrios
Summary: This study investigated the conformation of the beta-lactam resistome in Escherichia coli strains causing nosocomial infections. The results showed a multi-drug-resistance phenotype against beta-lactam drugs, primarily driven by the expression of the blaTEM gene family.
Article
Infectious Diseases
Nadezhda K. Fursova, Evgenii Astashkin, Olga N. Ershova, Irina A. Aleksandrova, Ivan A. Savin, Tatiana S. Novikova, Galina N. Fedyukina, Angelina A. Kislichkina, Mikhail Fursov, Ekaterina S. Kuzina, Sergei F. Biketov, Ivan A. Dyatlov
Summary: This study identified genetic lineages, antimicrobial resistance, and virulence genes in Klebsiella pneumoniae isolates associated with severe infections in neuro-ICU. Specific sequence types were found to be linked to fatal outcomes, indicating high virulence potential.
Article
Biochemical Research Methods
Khonaw Kader Salh
Summary: This study investigated the isolation of etiologic agents from patients with urinary tract infections (UTIs) and found that Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) were the most common causative bacteria. It also identified a high incidence of extended-spectrum β-lactamase (ESBL) genes and recorded high resistance to multiple antibiotics. The study emphasizes the importance of formulating effective antibiotic treatment policies in Iraq.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Chemistry, Analytical
Katarina Rebrosova, Silvie Bernatova, Martin Siler, Magdalena Uhlirova, Ota Samek, Jan Jezek, Veronika Hola, Filip Ruzicka, Pavel Zemanek
Summary: Urinary tract infections are among the most common infections worldwide. This study demonstrates that Raman spectroscopy can be used as a rapid diagnostic tool to differentiate causative agents and determine antimicrobial susceptibility. It holds great potential for clinical diagnostics in the future.
ANALYTICA CHIMICA ACTA
(2022)
Article
Microbiology
Malini Shariff, Elizabeth Ramengmawi
Summary: This study aimed to investigate anaerobes causing respiratory tract infections and their antibiotic susceptibility. The results showed variable resistance of many anaerobic bacteria to most classes of antibiotics.
Article
Gastroenterology & Hepatology
Lyvianne Decourtye-Espiard, Parry Guilford
Summary: Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). It is caused by germline mutations in the CDH1 and CTNNA1 genes. This article discusses the genetics, clinical phenotype, pathology, tumor initiation mechanism, natural history, and clinical management of HDGC.
Article
Microbiology
Karen Leth Nielsen, Marc Stegger, Kristoffer Kiil, Berit Lilje, Karen Ejrnaes, Rikke Fleron Leihof, Line Skjot-Rasmussen, Paul Godfrey, Tor Monsen, Sven Ferry, Anette M. Hammerum, Niels Frimodt-Moller
Summary: This study used a genomic approach to investigate recurrent urinary tract infections, finding limited adaptation and polymorphisms in metabolism genes among recurrent isolates. Though some genes were more common in rUTI isolates, overall, recurrent isolates did not show distinct variation in the core genome compared to non-rUTI isolates.
Article
Microbiology
Cong Shen, Jinxiang Zeng, Dexiang Zheng, Yinglun Xiao, Jieying Pu, Li Luo, Hongyun Zhou, Yimei Cai, Liling Zhang, Meina Wu, Xuan Zhang, Guangyuan Deng, Song Li, Qiwei Li, Jianming Zeng, Zhaohui Sun, Bin Huang, Cha Chen
Summary: Pseudomonas aeruginosa (P. aeruginosa) is a leading cause of chronic infections, and relapse infections are more common in carbapenem-resistant strains. This study identified relapse infections in a tertiary hospital in China and found that they were not caused by specific lineages. Genomic changes, including antimicrobial resistance and gene mutations, were observed during relapse episodes. A specific mutation in the fptA gene could be a potential target for the diagnosis and treatment of relapse P. aeruginosa infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Cong Shen, Jinxiang Zeng, Dexiang Zheng, Yinglun Xiao, Jieying Pu, Li Luo, Hongyun Zhou, Yimei Cai, Liling Zhang, Meina Wu, Xuan Zhang, Guangyuan Deng, Song Li, Qiwei Li, Jianming Zeng, Zhaohui Sun, Bin Huang, Cha Chen
Summary: Pseudomonas aeruginosa is a leading cause of chronic infections, especially in cystic fibrosis patients. In this study, we observed a high incidence of relapse P. aeruginosa infection in China, with carbapenem-resistant strains being more prevalent. Whole-genome sequencing revealed the dynamic changes and evolution of this pathogen during relapse episodes. A convergent non-synonymous mutation in a virulence gene could be a potential target for diagnosis and treatment. Integrated utilization of WGS and medical records provides opportunities for improved diagnostics of relapse infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Yingmiao Zhang, Yue Fan, Yu Zhan, Hao Wang, Xun Li, Hui Wang, Tian Feng, Lifeng Shi, Jing Wang, Zhongxin Lu
Summary: This study reports the first case of human infection caused by P. anthophila in China, providing a fundamental resource for further investigation of its virulence factors, antibiotic resistance, host-pathogen interactions, and comparative genomics of the Pantoea genus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
