Article
Immunology
Bijaya Sharma, Julie E. McCarthy, Cecily A. Freliech, Morgen M. Clark, Linden T. Hu
Summary: Unrecognized immunodeficiency may contribute to antibiotics' failure in treating Lyme disease symptoms. The study showed that the efficacy of doxycycline was significantly lower in mice lacking adaptive immunity, especially B cells, with the most pronounced effect seen in immunodeficient C3H mice. Additionally, the addition of a single dose of ceftriaxone to doxycycline treatment effectively cleared infection in severely immunodeficient C3H mice.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Bryna L. Fitzgerald, Barbara Graham, Mark J. Delorey, Adoracion Pegalajar-Jurado, M. Nurul Islam, Gary P. Wormser, John N. Aucott, Alison W. Rebman, Mark J. Soloski, John T. Belisle, Claudia R. Molins
Summary: This study used metabolomics to analyze metabolic responses in patients with Post-treatment Lyme disease symptoms/syndrome (PTLDS) compared to clinically cured non-PTLDS patients. The findings revealed observable metabolic differences between PTLDS and non-PTLDS patients at multiple time points, with distinct patterns of metabolite abundance. A small number of metabolites could be used to define PTLDS versus non-PTLDS patients at specific time points, and these findings were validated in a second patient cohort. These results suggest that metabolite-based measurement can help distinguish patients with PTLDS and provide insights into the underlying biochemistry of PTLDS.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Maroun M. Sfeir, Jennifer K. Meece, Elitza S. Theel, Dane Granger, Thomas R. Fritsche, Allen C. Steere, John A. Branda
Summary: Modified two-tiered testing algorithms are acceptable alternatives for Lyme disease diagnosis. The study found that these algorithms showed higher sensitivity in patients with acute erythema migrans and comparable specificity in other types of Lyme disease patients and control subjects.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Health Care Sciences & Services
Finja Huendersen, Stefanie Forst, Erich Kasten
Summary: The study found that patients with Lyme disease have lower quality of life and sleep, as well as cognitive impairments in attention and memory. Depressive symptoms are common among Lyme patients, and the disease is often diagnosed late.
Article
Medicine, General & Internal
Klaudia Sowula, Joanna Szaleniec, Mateusz Dworak, Maria Przeklasa, Malgorzata Maraj, Piotr Ceranowicz, Jerzy Tomik
Summary: The study aimed to evaluate the frequency of vertigo symptoms and potential labyrinth damage in patients diagnosed with Lyme disease (LD). Vertigo is often associated with labyrinth and hearing-organ damage in LD patients, and antibiotic therapy is effective in reducing otoneurological symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Priyanka G. Mukherjee, Dionysios Liveris, Klara Hanincova, Radha Iyer, Gary P. Wormser, Weihua Huang, Ira Schwartz
Summary: Lyme disease in the United States is mainly caused by Borrelia burgdorferi sensu stricto. After a tick bite, patients may develop erythema migrans. If dissemination occurs, neurologic manifestations, carditis, or arthritis may follow. OspC, a surface protein, is essential in early infection, but it is not the sole determinant of dissemination.
INFECTION AND IMMUNITY
(2023)
Article
Immunology
Hanna Schmid, Ulrich Heininger
Summary: Lyme disease, caused by Borrelia burgdorferi infection, presents with well-defined symptoms that can be treated with appropriate antibiotics. However, some patients may experience persistent nonspecific symptoms after treatment. Posttreatment Lyme disease syndrome is a diagnosis of exclusion and requires careful evaluation to avoid overdiagnosis and overtreatment.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Shaghayegh Jahanbani, Paige S. Hansen, Lisa K. Blum, Effie E. Bastounis, Nitya S. Ramadoss, Mallesh Pandrala, Jessica Marie Kirschmann, Grace Sisemore Blacker, Zelda Z. Love, Irving L. Weissman, Fahimeh Nemati, Michal Caspi Tal, William H. Robinson
Summary: This study sequenced the antibody repertoire of plasmablasts in Bb-infected humans and identified their binding specificities. The researchers found that by conjugating a TLR9-agonist CpG oligo to an anti-BmpA monoclonal antibody, they were able to enhance macrophage phagocytosis of Bb.
CLINICAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Elisa Kortela, Mari Kanerva, Satu Kurkela, Jarmo Oksi, Asko Jarvinen
Summary: This study evaluated the conditions behind the symptoms in patients with suspected Lyme borreliosis (LB) referred to an infectious diseases clinic. The results showed that LB was unlikely in half of the patients, with most cases having other conditions to explain their symptoms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Christa D. Jackson, Kinsey A. Hilliard, Charles R. Brown
Summary: The deficiency of 12/15-lipoxygenase (12/15-LO) exacerbates ankle swelling and arthritis severity in Lyme arthritis, suggesting that 12/15-LO lipid metabolites play a crucial role in resolving inflammatory arthritis. Therapeutic treatment with lipoxin A4 (LXA(4)) can alleviate joint edema and pain in Lyme arthritis patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sanna Avellan, Daniel Bremell
Summary: The study found that adjunctive corticosteroids do not improve or impair the outcome for patients with LNB PFP treated with doxycycline.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Hanna Schmid, Ulrich Heininger
Summary: Lyme disease caused by Borrelia burgdorferi infection can lead to well-defined symptoms at early or late stages, with appropriate antibiotic therapy typically resulting in a favorable outcome. However, some patients may experience persistent unspecific symptoms despite treatment, the underlying mechanism of which remains unclear.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Microbiology
Paul M. Arnaboldi, Adiya S. Katseff, Mariya Sambir, Raymond J. Dattwyler
Summary: This study evaluated the efficacy of using synthetic peptides containing unique epitopes from B. burgdorferi as antigen targets in Lyme disease seroassay. The results showed that combining epitopes from different antigens significantly increased the sensitivity of the assay without compromising specificity. These findings provide a new approach to improve the laboratory diagnosis of Lyme disease.
Article
Immunology
Bharti Bhatia, Chadwick Hillman, Philip E. Stewart, Patricia Rosa
Summary: The highly conserved gene bba30 on the linear plasmid lp54 of Lyme disease spirochetes was found to be not required during the experimental mouse-tick infectious cycle, suggesting its potential role in the natural life cycle of Borrelia burgdorferi remains undefined.
INFECTION AND IMMUNITY
(2021)
Article
Microbiology
Gary P. Wormser, Donna McKenna, Eliana Jacobson, Elayna M. Shanker, Keith D. Shaffer, Carol Scavarda, Paul Visintainer
Summary: The study found that patients with erythema migrans who received antibiotic treatment for less than 7 days were more likely to experience at least one symptom than those treated for 7 days or more. Additionally, there was a significantly lower percentage of males among the treated group compared to untreated study subjects.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Gavin M. Traber, Ai-Ming Yu
Summary: RNA interference (RNAi) is a versatile method for regulating gene expression. Endogenous microRNAs (miRNAs) and exogenous small interfering RNAs (siRNAs) form RNA-induced silencing complexes to achieve gene regulation. RNAi-based drugs have been approved for clinical use and advancements in technology aim to improve their efficacy and safety. Chemical modifications and delivery platforms are being explored to enhance the structure, stability, and activity of RNA molecules. Novel biologic RNAi agents are also being developed for research purposes.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Microbiology
Yijie Deng, Shiao Y. Wang
Summary: This study investigates the role of biofilm in cellulose degradation using Bacillus subtilis. It shows that biofilm is able to absorb and retain cellulase, leading to increased cellulose degradation by bacteria that produce more biofilm.
Article
Multidisciplinary Sciences
Peng Rao, Yijie Deng, Wenjun Fan, Junming Luo, Peilin Deng, Jing Li, Yijun Shen, Xinlong Tian
Summary: In this study, multiple single metal atoms were successfully anchored onto carbon supports as high-entropy single-atom catalysts using a movable typing method. This opens up a new approach for investigating highly efficient single-atom catalysts with multiple compositions.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Qilong Ye, Mengwei Li, Sanying Hou, Yijie Deng, Junming Luo, Xinlong Tian
Summary: An efficient hierarchical porous carbon catalyst for the oxygen reduction reaction was developed in this study through a simple solid-phase synthesis method. The introduction of zinc helped inhibit nanoparticle growth and agglomeration, leading to the formation of active nitrogen species and porosity, thereby enhancing the catalytic activity. The optimized FeZn-N-C-1 catalyst exhibited a high half-wave potential and demonstrated promising performance as a cathode in a zinc-air battery.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Jie Zhang, Mengwei Li, Qilong Ye, Peng Rao, Sanying Hou, Guanghua Wang, Yijie Deng, Xinlong Tian
Summary: A facile solid-state synthesis approach has been developed for the preparation of a hierarchical porous Fe-N-C oxygen reduction reaction (ORR) catalyst enriched with graphite carbon layer encapsulated Fe/Fe3C nanoparticles and Fe-Nx sites nanocomposites. This catalyst exhibits excellent ORR activity, surpassing commercial Pt/C in terms of half-wave potential and kinetic current densities. It also demonstrates a low yield of H2O2, 4-electron transfer pathway, and good stability.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Analytical
Lunyi Guo, Shining Mu, Yijie Deng, Chaofan Shi, Bo Yan, Zhuoling Xiao
Summary: Speech recognition has made great progress in the field of artificial intelligence, but there is a need to improve the performance of real-time offline Chinese speech recognition neural network accelerator for edge AI. This paper proposes a configurable convolutional neural network accelerator based on a lightweight speech recognition model, which can significantly reduce hardware resource consumption while ensuring an acceptable error rate. The accelerator achieves better energy efficiency, power consumption, and hardware resource consumption compared to other computing platforms.
Article
Nanoscience & Nanotechnology
Yijie Deng, Dongbo Wang, Yixiao Han
Summary: Shale gas is a renewable unconventional natural gas with abundant reserves. Its production has grown rapidly, impacting the international gas market and global energy landscape. Research on the variation in shale gas content with formation depth is crucial for exploring shale gas reserves and modeling their distribution.
Review
Pharmacology & Pharmacy
Joseph M. Cronin, Ai -Ming Yu
Summary: The development of medications requires a thorough understanding of their pharmacokinetic and pharmacodynamic properties. The study of ADME gene products and their functions has been revolutionized by recombinant DNA technologies. These technologies enable the investigation of drug metabolism and disposition, as well as the study of posttranscriptional regulation of ADME genes.
DRUG METABOLISM AND DISPOSITION
(2023)
Article
Geosciences, Multidisciplinary
Jia-Ming Deng, Tan Kin Wang, Sebastian Wege, Wan Ting Hu, Yi Jie Deng
Summary: Six long-offset multi-channel seismic profiles were reprocessed to generate pre-stack depth migration (PSDM) sections from TAIGER experiment in 2009 and TAICRUST project in 1995. Two velocity-interface models were obtained, considering the PSDM sections and previous tomography models. The subduction of Gagua Ridge caused uplift of sedimentary basement and lower crustal structure beneath the Nanao Basin, as indicated by the PSDM sections and velocity-interface models. A recent earthquake near Taiwan's northeast coast in 2018 at a depth of approximately 12 km below the Hsincheng Ridge was likely caused by a thrust fault near the decollement formed by the subduction of the Philippine Sea Plate.
TERRESTRIAL ATMOSPHERIC AND OCEANIC SCIENCES
(2023)
Article
Chemistry, Physical
Bin Chi, Longhai Zhang, Xiaoxuan Yang, Yachao Zeng, Yijie Deng, Mingrui Liu, Junlang Huo, Chaozhong Li, Xiaorong Zhang, Xiudong Shi, Yijia Shao, Lin Gu, Lirong Zheng, Zhiming Cui, Shijun Liao, Gang Wu
Summary: This study reports the co-doping of Zr and Fe dual metal sites into a ZIF-8-derived mesoporous carbon for improved durability and activity in the oxygen reduction reaction. The Zr-doped Fe-N-C catalyst showed only 25% voltage loss after 20 hours of continuous operation and retained 40% of its initial performance after 100 hours, outperforming the catalyst without Zr doping. The cathode also exhibited significantly enhanced ORR activity, achieving a maximum power density of 0.72 W cm-2.
Article
Microbiology
Brandon Ely, Winston Koh, Eamen Ho, Tasmina M. M. Hassan, Anh V. V. Pham, Weigang Qiu
Summary: Driven by host-pathogen coevolution, cell surface antigens are the fastest evolving parts of microbial pathogens. Novelty-seeking algorithms are useful in predicting antigen diversification in these pathogens. A hybrid algorithm combining fitness- and novelty-seeking strategies showed the best performance in predicting variant fitness peaks. The efficiency of the hybrid algorithm improves the predictability of novel antigen variants.
Article
Chemistry, Multidisciplinary
Chong Di, Brian Sulkow, Weigang Qiu, Shipeng Sun
Summary: The questing behaviors of blacklegged ticks are influenced by environmental factors at the micro scale, showing complex relationships with temperature, humidity, and vegetation composition, including nonlinearities and threshold effects.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Yixin Chen, Mei-Juan Tu, Fangwei Han, Zhenzhen Liu, Neelu Batra, Primo N. Lara, Hong -Wu Chen, Huichang Bi, Ai -Ming Yu
Summary: The research found that miR-22-3p, miR-9-5p, and miR-218-5p are antiproliferative miRNAs targeting non-small cell lung cancer (NSCLC) cells, and they inhibit folate metabolism and alter amino acid metabolism in NSCLC cells. In addition, the inhibition of glucose uptake by miR-22-3p and the reduction of serine biosynthesis from glucose by miR-9-5p and -218-5p were also confirmed. Recombinant miR-22-3p was more effective than miR-9-5p and -218-5p in inhibiting NSCLC cell respiration, glycolysis, and colony formation, without causing any toxicity.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Physical
Mengwei Li, Qilong Ye, Sanying Hou, Jinlin Yang, Bin Chi, Yijie Deng, Xinlong Tian
Summary: The rational design of low-cost and high-efficiency N-doped porous carbon electrocatalysts for oxygen reduction reaction is important for the commercialization of fuel cells. A nitrogen-doped carbon network coupled with fluorine and phosphorus atoms was successfully prepared through a facile and efficient strategy. The resulting catalyst exhibited excellent oxygen reduction performance, surpassing that of commercial Pt/C, and showed long-term stability in a homemade zinc-air battery.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Review
Chemistry, Multidisciplinary
Pengfei Meng, Xiaorong Zhang, Shijun Liao, Yijie Deng
Summary: Metal-nitrogen-carbon (M-Nx-C) catalysts possess high reactivity, selectivity, and ease of synthesis, and show potential to replace platinum-based catalysts. However, they face limitations in application due to low active site density and insufficient durability in the oxygen reduction process of fuel cells. Doping with various metal/nonmetal elements to modulate the electronic structure and spatial configuration of the active site has been found to greatly enhance the performance and stability of M-Nx-C catalysts, making it a popular research topic in the field.
PROGRESS IN CHEMISTRY
(2022)
