Editorial Material
Cell Biology
Andrea S. Pinto, Manisha Tambe, Selma Z. D'Silva, Meenakshi Singh
Summary: HLA-B*51:01:01:108 and HLA-B*40:387 alleles were detected during routine HLA typing.
Editorial Material
Cell Biology
Vinicius N. Stelet, Rafael F. Cita, Maristela F. Mendes, Matilde Romero, Eliana Abdelhay
Summary: A novel allele, HLA-A*01:01:01:53, has been identified which differs from HLA-A*01:01:01:01 at four positions in intron 1.
Editorial Material
Cell Biology
Tenzin Phuntsok, Jyoti Rajak, Selma Z. D'Silva, Manisha Tambe, Meenakshi Singh
Summary: The novel HLA-B*51:01:01:83 allele differs from HLA-B*51:01:01:01 by a nucleotide substitution from A to G at gDNA 2569.
Editorial Material
Cell Biology
Romulo Vianna, Giovanna Lopes, Xenia Georgiou, Thomas R. Turner, Luis Cristovao Porto
Summary: The novel HLA-DPB1*04:01:51 allele was first described in a potential bone marrow donor from Brazil.
Editorial Material
Cell Biology
Luis Alberto Marin Rubio, Ramon Rada, Jesus Ontanon
Summary: Four novel HLA alleles, HLA-B*40:02:01:26, HLA-DQB1*03:01:01:29, HLA-DQB1*04:02:01:12 and HLA-DPB1*1195:01, have been detected in Spanish individuals.
Article
Immunology
Ruihua Wang, Ying Sun, Bo-Hua Kuang, Xiao Yan, Jinju Lei, Yu-Xin Lin, Jinxiu Tian, Yating Li, Xiaoduo Xie, Tao Chen, Hui Zhang, Yi-Xin Zeng, Jincun Zhao, Lin Feng
Summary: The impact of HLA and KIR genotypes and their combinations on COVID-19 outcome was investigated. Individuals with the HLA-Bw4/KIR3DL1 combination had a 58.8% lower risk of developing severe COVID-19. This suggests that the synergistic responsiveness of CTLs and NK cells can efficiently control SARS-CoV-2 infection and replication.
EMERGING MICROBES & INFECTIONS
(2023)
Editorial Material
Cell Biology
Luis Alberto Marin Rubio, Jesus Ontanon
Summary: Four new HLA Class II alleles, HLA-DPA1*01:03:01:68, -DPA1*01:03:01:71, -DQA1*02:01:01:06, and -DQB1*06:03:01:19, have been identified in Spanish individuals.
Editorial Material
Cell Biology
Luis Alberto Marin Rubio, Jesus Ontanon
Summary: Four novel HLA-DQA1 alleles were identified in Spanish individuals.
Editorial Material
Cell Biology
Jyoti Rajak, Bansi Parsaniya, Andrea S. S. Pinto, Selma Z. Z. D'Silva, Meenakshi Singh
Summary: Novel HLA-A*33:03:62, -B*52:01:01:25 alleles were identified, and the presence of HLA-A*02:01:209 allele was confirmed during the HLA typing process.
Editorial Material
Cell Biology
Evgeny A. Leonov, Ekaterina G. Khamaganova, Elena P. Kuzminova, Alena R. Abdrakhimova, Tatiana V. Gaponova
Summary: Two new gene variants HLA-A*26:01:01:53 and DRB1*01:141 have been identified in Russian individuals.
Editorial Material
Cell Biology
Elena P. P. Kuzminova, Evgeny A. A. Leonov, Alena R. R. Abdrakhimova, Stanislav P. P. Khizhinskiy, Ekaterina G. G. Khamaganova
Summary: Two new alleles B*18:01:01:74 and C*06:02:01:93 have been identified in Russian individuals.
Article
Cell Biology
Maria Loginova, Daria Smirnova, Igor Paramonov
Summary: The specific HLA gene sequences of HLA-B*08:01:71, HLA-B*51:382, and HLA-B*55:01:30 are reported.
Article
Health Care Sciences & Services
Shobana John, Karuppiah Balakrishnan, Chonlaphat Sukasem, Tharmarajan Chinnathambi Vijay Anand, Bhutorn Canyuk, Sutthiporn Pattharachayakul
Summary: This study investigated the association of genetic variants of the HLA B gene and CYP2C9*3 with PHT-CADRs in South Indian epileptic patients. The findings revealed significant associations of CYP2C9*3 with overall PHT-CADRs, and identified HLA B*51:01, CYP2C9*3, and HLA B*55:01 as risk factors for PHT-CADRs in the South Indian Tamil population. Further research with larger sample sizes is needed to validate the clinical relevance of these alleles.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Cell Biology
Manisha Tambe, Jyoti Rajak, Andrea S. Pinto, Selma Z. D'Silva, Meenakshi Singh
Summary: The novel allele HLA-B*37:01:01:19 differs from B*37:01:01:01 by a single nucleotide change, A->G, at gDNA1430 in Intron 3.
Editorial Material
Cell Biology
Manli Shen, Brian F. Duffy, Jo-Ellen Jennemann, Bijal A. Parikh, Chang Liu
Summary: DQA1*01:99 differs from DQA1*01:01 by a missense nucleotide substitution in exon 4.
Review
Immunology
Mohammad Reza Haghshenas, Hamid Ghaderi, Hossein Daneste, Abbas Ghaderi
Summary: Salivary glands play a crucial role in oral immunity. Immune components and responses in the tumor microenvironment of salivary gland tumors are being investigated. Immune checkpoint molecules and chemokines are potential targets for cancer immunotherapy.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Immunology
Faezeh Maghsood, Mohammad-Reza Shokri, Mahmood Jeddi-Tehrani, Monireh Torabi Rahvar, Abbas Ghaderi, Vahid Salimi, Gholam Ali Kardar, Amir-Hassan Zarnani, Mohammad Mehdi Amiri, Fazel Shokri
Summary: IgG responses to RBD and NP in COVID-19 patients were found to be dominated by conformational and linear epitopes, respectively. The reactivity of patients' sera with reduced recombinant RBD protein was significantly lower than the native form, while no significant differences were observed for NP protein. The identification of immunodominant epitopes in NP and RBD could be valuable for the development of immunotherapy and diagnostic tools for COVID-19.
PATHOGENS AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Mohammad Javad Fattahi, Mohammad Reza Haghshenas, Abbas Ghaderi
Summary: The initiation and progression of bladder cancer rely on its tumor microenvironment, which is influenced by immune cells. Immunometabolism plays a crucial role in immune cell function and immune response in bladder cancer. Understanding the metabolic reprogramming of bladder cancer cells and immune cells in the tumor microenvironment can provide new opportunities for targeted therapies.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Immunology
Atri Ghods, Fereshteh Mehdipour, Reza Rasolmali, Abdol-Rasoul Talei, Abbas Ghaderi
Summary: This study focused on the expression of membranous and intracellular forms of TNF-alpha in lymphocytes derived from breast cancer-draining lymph nodes. The results showed that CD4+T cells primarily express the membranous form, while CD8+T cells primarily express the intracellular form. The intensity of membranous TNF-alpha expression in CD19+ cells was correlated with poor prognosticators, and the frequency of membranous TNF-alpha+CD19+ cells showed an inverse correlation with the number of involved lymph nodes.
CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Marjan Hematian Larki, Elham Ashouri, Shaghik Barani, Seiyed Mohammad Ali Ghayumi, Abbas Ghaderi, Raja Rajalingam
Summary: The study reveals the association between KIR and HLA class I ligands with genetic predisposition to lung cancer in the native population of southern Iran. Specific KIR genes and HLA-C1 ligands show significant increase in patients with lung cancer, certain genotypes are positively correlated with disease risk, and iKIRs > aKIRs genotypes are more frequently presented in lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Samira Tabaei, Mohammad Reza Haghshenas, Thomas J. Webster, Abbas Ghaderi
Summary: Urothelial bladder cancer (UBC) is a complex malignancy with a high recurrence rate. Current diagnostic procedures lack sensitivity and specificity, thus biomarkers have potential value for early diagnosis, prognosis, and immunotherapy. Proteomics methods have rapidly advanced in identifying UBC biomarkers, and a panel of biomarkers may achieve higher diagnostic accuracy. This review evaluates recent literature on UBC proteomics, classifies tumor biomarkers based on their sources, and discusses the limitations and advantages of each source.
ANALYTICAL BIOCHEMISTRY
(2023)
Review
Genetics & Heredity
William H. H. Palmer, Paul J. J. Norman
Summary: Human Leukocyte Antigens (HLA) are cell surface molecules that play a central role in coordinating immune responses and undergo strong diversifying natural selection by pathogens. This review synthesizes genetic associations of HLA with herpesvirus infection and disease, identifying HLA alleles associated with diverse herpesvirus-related phenotypes. The study also discusses mechanisms by which different HLA and cognate receptor allotypes direct variable immune responses during herpesvirus infection and pathogenesis.
Editorial Material
Genetics & Heredity
Paul J. Norman
Article
Hematology
Camille Philippon, Sudan Tao, Dennis Clement, Alvaro Haroun-Izquierdo, Katherine M. Kichula, Herman Netskar, Ludwig Brandt, Vincent Sheng Oei, Minoru Kanaya, Pilar Maria Lanuza, Marie Schaffer, Jodie P. Goodridge, Amir Horowitz, Faming Zhu, Quirin Hammer, Ebba Sohlberg, Rakesh Kumar Majhi, Lise Kveberg, Bjorn Onfelt, Paul J. Norman, Karl-Johan Malmberg
Summary: The functionality of NK cells is influenced by genetic variation in KIR and HLA genes, which fine-tunes the payload of effector molecules in secretory lysosomes. Granzyme B levels in NK cells are genetically determined by allelic variation in HLA class I genes and serve as a robust metric of NK cell function. Variation in granzyme B levels at rest is closely linked to the killing of target cells.
Article
Cell Biology
Amin Ramezani, Mohammadrasul Zareinejad, Elham Mahmoudi Maymand, Elina Kaviani, Abbas Ghaderi
Summary: This study aimed to produce a biosimilar version of aflibercept (AFL) and evaluate its effect when used in combination with other vascular endothelial growth factor (VEGF) blocker drugs. The biosimilar-AFL showed significant inhibition potential on HUVEC cells in a dose-dependent manner. Furthermore, co-treatment with Everolimus (EVR), Lenvatinib (LEN), and Sorafenib (SOR) enhanced the cytotoxicity of biosimilar-AFL on HUVEC cells, with LEN and SOR showing a 10-fold increase in cytotoxicity. The combination of biosimilar-AFL with LEN showed the most efficient result, while the combination with EVR showed the least efficient result. Overall, biosimilar-AFL may improve the efficacy of LEN, EVR, and SOR in reducing the VEGF effect on endothelial cells.
Article
Biochemical Research Methods
Samira Tabaei, Mohammad Reza Haghshenas, Ali Ariafar, Kambiz Gilany, Allan Stensballe, Shirin Farjadian, Abbas Ghaderi
Summary: The aim of this study is to recognize tumor-associated proteins, which are differentially expressed in different stages of UBC patients compared to non-cancerous tissues. The study found significant changes in protein expression related to oxidative stress and antioxidant activity in UBC patients. These findings may contribute to the development of promising biomarkers for early detection, monitoring, and prognosis of UBC.
CLINICAL PROTEOMICS
(2023)
Article
Cell Biology
Ticiana D. J. Farias, Silvia Brugiapaglia, Susanna Croci, Paola Magistroni, Claudia Curcio, Kristina Zguro, Chiara Fallerini, Francesca Fava, Francesco Pettini, Katherine M. Kichula, Nicholas R. Pollock, Neus Font-Porterias, William H. Palmer, Wesley M. Marin, Margherita Baldassarri, Mirella Bruttini, Jill A. Hollenbach, Audrey E. Hendricks, Ilaria Meloni, Francesco Novelli, Alessandra GEN-COVID Multictr Study Grp, Alessandra Renieri, Simone Furini, Paul J. Norman, Antonio Amoroso
Summary: The extreme polymorphism of HLA and KIR is associated with the severity of COVID-19. Possession of the activating KIR2DS4*001 allotype and HLA-DPB1*13:01 is linked to increased and decreased hospitalization risk, respectively. Autoantibodies against IFN-alpha are also correlated with COVID-19 severity.
Article
Immunology
William H. Palmer, Laura Ann Leaton, Ana Campos Codo, Bergren Crute, James Roest, Shiying Zhu, Jan Petersen, Richard P. Tobin, Patrick S. Hume, Matthew Stone, Adrie van Bokhoven, Mark E. Gerich, Martin D. McCarter, Yuwen Zhu, William J. Janssen, Julian P. Vivian, John Trowsdale, Andrew Getahun, Jamie Rossjohn, John Cambier, Liyen Loh, Paul J. Norman
Summary: Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK) cells and recognize HLA class I molecules as ligands. However, KIR3DL3 is expressed in γδ and CD8(+) T cells and recognizes the B7 family ligand HHLA2, playing a role in immune checkpoint targeting. KIR3DL3(+) T cells in peripheral blood have an activated transitional memory phenotype and are hypofunctional, with biased T cell receptor (TCR) usage. Additionally, KIR3DL3 expression can be influenced by polymorphisms and variants in the proximal promoter and residue 86. These findings have implications for personalized targeting of KIR3DL3/HHLA2 checkpoint inhibition.
SCIENCE IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi
Summary: This study found that there is no direct correlation between the SNP of lncRNA ANRIL rs4977574 and the presence of oral squamous cell carcinoma (OSCC). However, it was observed that the SNP is associated with smaller tumor size and higher level of cancer cell differentiation.
INTERNATIONAL JOURNAL OF DENTISTRY
(2023)
Article
Oncology
Hamid Ghaderi, Estie Kruger, Simin Ahmadvand, Yousef Mohammadi, Bijan Khademi, Abbas Ghaderi
Summary: This study conducted a comprehensive epidemiological analysis of salivary gland tumors in the south of Iran and found that benign tumors were the most prevalent type, with the parotid gland being the most common site. It also revealed that malignant tumors were more common among older patients.
JOURNAL OF CANCER EPIDEMIOLOGY
(2023)