期刊
CHEMISTRYSELECT
卷 1, 期 3, 页码 630-634出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201600181
关键词
Homocoupling; Biaryl compounds; Palladium Catalysis; O,O-Ligand; 1,4-Butanediol
资金
- Nation Science and Technology Major Project of China [521042]
A mild, efficient and environmentally friendly method for the synthesis of biaryl compounds via palladium-catalyzed reductive homocoupling of aryl halides in 1,4-butanediol (1,4-DBO) has been developed. In this catalyst system, green solvent-1,4butanediol is used not only as solvent, but also as reductant and O,O-ligand,and therefore no extra reducing agents and ligands are required. Moreover, the weak coordinate effect brings 1,4-butanediol close to the palladium and accelerates the process of electron transfer in a four-membered ring transition state and hence promotes the reduction and catalytic process. A variety of biaryl compounds have been synthesized via this protocol rapidly with low loading of palladium catalyst under mild conditions in air.
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