期刊
CHEMISTRYSELECT
卷 1, 期 10, 页码 2174-2180出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201600379
关键词
Asymmetric synthesis; Camphor; Schiff base; Sulfoxidation; Vanadium
资金
- Ministry of Science and Technology of Taiwan [MOST 103-2113-M-277001-MY3]
Novel in situ formed vanadium Schiff base complexes, namely vanadyl Schiff base of 3-exo-aminoisoborneol (V(O)-SBAIB) and vanadyl Schiff base of 3-endo-aminoborneol (V(O)-SBAB), were demonstrated to catalyze an enantioselective sulfoxidation reaction. Among the twenty substitutionally and electronically different (1R)-camphor based Schiff base ligands, 6-bromo-2hydroxy-1-naphthaldehyde Schiff base of 3-endo-aminoborneol, 48 (SBAB-14), produced (S)-ethyl 2-naphthyl sulfoxide in excellent enantioselectivity (> 99%) with good yield (72%). In an optimized reaction condition, 1.5 mol% 48 (SBAB-14) catalyzed asymmetric sulfoxidation with concomitant kinetic resolution of various alkyl aryl sulfides and rendered corresponding sulfoxides with high ee (up to 97%) with moderate yield (up to 74%).
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