Article
Medicine, General & Internal
Muhammad Abu Tailakh, Shlomo-yaron Ishay, Jenan Awesat, Liat Poupko, Gidon Sahar, Victor Novack
Summary: The study found that diabetes patients with HbA1c levels above 7% before coronary artery bypass grafting are at higher risk for long-term mortality, especially late mortality; while patients with HbA1c levels below 7% have a relatively lower mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Paul R. Conlin, Libin Zhang, Donglin Li, Richard E. Nelson, Julia C. Prentice, David C. Mohr
Summary: The treatment goals for hemoglobin A1c (A1c) in older adults should be personalized to balance risks and benefits. It is uncertain if stability of A1c within target ranges affects adverse outcomes.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Endocrinology & Metabolism
Guanhua Chen, Rui Zhang, Chunlu Tan, Xubao Liu, Lei Yu, Yonghua Chen
Summary: Using HbA1c alone as a diagnostic criterion for diabetes may not be sensitive enough in patients with pancreatic diseases. The optimal values of 5.8% and 6.0% for HbA1c improved the accuracy of diagnosing prediabetes and diabetes and should be considered. Furthermore, combining HbA1c and FPG tests is advocated for diagnosing diabetes in patients with pancreatic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Ygal Plakht, Harel Gilutz, Arthur Shiyovich
Summary: This study evaluated the prognostic significance of HbA(1C) levels and changes among diabetic patients after non-fatal AMI. The results showed that fluctuations in HbA(1C) values, especially rapid increases, were associated with a higher risk of mortality. Monitoring both absolute HbA(1C) values and their changes could help predict long-term outcomes in AMI-DM patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shu-Tin Yeh, Seng-Wei Ooi, Ya-Hui Chang, Chung-Yi Li, Hua-Fen Chen
Summary: This study investigated the age- and sex-specific rates of mortality and relative hazards of mortality associated with visit-to-visit variability (VVV) of glycated hemoglobin (HbA1c) levels. The results showed that the lowest all-cause mortality rate was found in the first or second quartile of various measures for VVV, while the highest mortality rate was consistently observed in the fourth quartile of VVV.
Article
Cardiac & Cardiovascular Systems
Dan Huang, Yong-Quan Huang, Qun-Ying Zhang, Yan Cui, Tian-Yi Mu, Yin Huang
Summary: The study found that greater variability of HbA1c is associated with higher risk for cardiovascular complications and all-cause death in patients with type 2 diabetes. It highlights the significance of well-controlled glycemic levels in improving cardiovascular outcomes. Further randomized clinical trials are needed to confirm these findings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Electrical & Electronic
Namho Kim, Da Young Lee, Wonju Seo, Nan Hee Kim, Sung-Min Park
Summary: The study aimed to develop clustering-based personalized models to estimate hemoglobin A1c (HbA1c) levels from continuous glucose monitoring (CGM) values. The proposed models showed improved performance in estimating HbA1c levels and provided real-time integrated information for better glycemic control.
IEEE SENSORS JOURNAL
(2022)
Review
Medicine, General & Internal
Furong Qu, Qingyang Shi, Yang Wang, Yanjiao Shen, Kaixin Zhou, Ewan R. Pearson, Sheyu Li
Summary: This systematic review summarizes the evidence of HbAlc variability in patients with type 2 diabetes. The findings suggest that high HbAlc variability is associated with increased risks of all-cause mortality, cardiovascular events, progression to chronic kidney disease, amputation, and peripheral neuropathy. Therefore, patients with type 2 diabetes and high HbAlc variability require additional attention and care for potential adverse outcomes.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Alexandra Halalau, Sujoy Roy, Arpitha Hegde, Sumesh Khanal, Emily Langnas, Maidah Raja, Ramin Homayouni
Summary: This study aimed to determine the risk factors associated with rapid progression from normal or prediabetic hemoglobin A1c levels to type 2 diabetes mellitus. The results showed that progression to diabetes within a four-year period is associated with baseline BMI. A steady rise in HbA1c during the same period is associated with age and family history of type 2 diabetes, while rapid rise in HbA1c is associated with age and personal history of major cardiovascular events.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sabaa Joad, Elliot Ballato, F. N. U. Deepika, Giulia Gregori, Alcibiades Leonardo Fleires-Gutierrez, Georgia Colleluori, Lina Aguirre, Rui Chen, Vittoria Russo, Virginia Carolina Fuenmayor Lopez, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: The study aims to identify a hemoglobin A1c threshold level by which reduction in bone turnover begins in men with type 2 diabetes mellitus. Results show that an A1c level of 7% or greater is associated with lower bone turnover in the study population and specifically in men with T2D.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Amy J. Patel, Stanislaw P. Klek, Virginia Peragallo-Dittko, Michael Goldstein, Eric Burdge, Victoria Nadile, Julia Ramadhar, Shahidul Islam, Gary D. Rothberger
Summary: There was no significant association between HbA1C level and adverse clinical outcomes in hospitalized diabetes patients with COVID-19. Therefore, HbA1C levels should not be used for risk stratification in these patients.
ENDOCRINE PRACTICE
(2021)
Article
Medical Laboratory Technology
Dabao He, Wenbin Kuang, Xiaoling Yang, Miao Xu
Summary: The study found that HbA1c levels were significantly lower in patients with HbH disease compared to healthy individuals, while GA showed no significant difference between the two groups. Using HbA1c as a diagnostic criterion for diabetes may lead to a considerable number of diabetic patients with HbH disease being missed. GA, instead of HbA1c, is suitable for monitoring glycemic control in patients with HbH disease and can modify HbA1c's discriminative ability for diagnosing diabetes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Xu Huang, Cheng Qin, Xiaoxu Guo, Feng Cao, Chengchun Tang
Summary: This study investigated the relationship between HbA1c and the incidence of hypertension in a large prospective cohort. The findings suggest that HbA1c is linearly and positively associated with the risk of hypertension, particularly in female, lower education level, and non-obese subgroups. HbA1c can be considered as a predictor for hypertension risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dea Haagensen Kofod, Nicholas Carlson, Ellen Freese Ballegaard, Thomas Peter Almdal, Christian Torp-Pedersen, Gunnar Gislason, Jesper Hastrup Svendsen, Bo Feldt-Rasmussen, Mads Hornum
Summary: This study investigated the risk of cardiovascular mortality in patients with advanced chronic kidney disease (CKD). The results showed that diabetes, albuminuria, and anemia were significant risk factors for cardiovascular mortality, while the predictive value of LDL-cholesterol for cardiovascular mortality in advanced CKD may be limited.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Ying Wei, Zhenyu Wu, Ying Wang, Guang Wang, Jia Liu
Summary: The study found that the hemoglobin glycation index (HGI) is associated with sex and diabetes, with glycemic control in women with diabetes being negatively correlated with serum uric acid levels, while blood glucose and HGI in women without diabetes are positively correlated with serum uric acid levels. The relationship between serum uric acid levels in men with prediabetes and glycated hemoglobin is bell-shaped.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
