Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Fatemeh Yazdian, Ali Koulivand, Erfan Rahmani
Summary: Cancer is a challenging disease with high patient and death rates. Chemotherapy is commonly used to treat cancer, and metal oxide nanoparticles have shown promise in combination therapy to enhance drug effectiveness. A pH-responsive nanocomposite made of PVP, Ag, and TiO2 can overcome limitations of current cancer treatments and deliver drugs effectively.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Yuping Chen, Hesong Wu, Tao Yang, Guanshan Zhou, Yuyin Chen, Jie Wang, Chuanbin Mao, Mingying Yang
Summary: This study combined silk fibroin (SF) and zeolitic imidazolate framework-8 (ZIF-8) to develop a novel drug carrier for selectively releasing an anti-tumor drug, doxorubicin (DOX), in the acidic intracellular environment of cancer cells. The core-shell-structured nanoparticles consisted of ZIF-8 as the shell and DSF-NP as the core, showing high stability under neutral conditions and efficient inhibition of tumor growth by inducing cell apoptosis both in vitro and in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Lu Wang, Yunfeng Yan
Summary: RNA interference (RNAi) has potential in treating cancer and genetic disorders, but safe delivery methods remain a challenge. pH-responsive hybrid nanoparticles offer promise for siRNA delivery, with unique properties and potential benefits for therapeutic applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Biochemistry & Molecular Biology
Hongda Cheng
Summary: Metal-organic frameworks (MOFs) are promising materials for drug delivery. In this study, a Zinc-based MOF nanocomposite IRMOF-3 was used as a drug carrier for 10-hydroxycamptothecine (HCPT). The HCPT@IRMOF-3 nanoscale drug delivery material was prepared via one-pot synthesis, without the need for an extra drug-loading process. The material showed pH-responsive drug release, with a higher drug-loading capacity compared to traditional methods.
Article
Pharmacology & Pharmacy
Xiaoran Cai, Xiaolei Wang, Muye He, Yan Wang, Minbo Lan, Yuzheng Zhao, Feng Gao
Summary: The study successfully developed an oral nanoparticle delivery system for the effective treatment of inflammatory bowel disease by preparing FK506/HP-β-CD inclusion compounds and adsorbing ES100 and HA onto the nanoparticles loaded with FK506/HP-β-CD through electrostatic interactions. FK506@EHCh NPs displayed promising results in suppressing inflammation and showed potential for targeted treatment of inflammatory bowel disease.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Rushikesh P. Dhavale, R. P. Dhavale, S. C. Sahoo, P. Kollu, S. U. Jadhav, P. S. Patil, T. D. Dongale, A. D. Chougale, P. B. Patil
Summary: The study successfully utilized chitosan-coated magnetic nanoparticles as a carrier to load the poorly water-soluble anticancer drug TEL, achieving effective inhibition of human prostate cancer cells and demonstrating pH-responsive controlled release characteristics. The designed nanoformulation showed significant antitumor activity.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2021)
Article
Chemistry, Multidisciplinary
Sijun Zeng, Xuebo Quan, Huilin Zhu, Delin Sun, Zhaohong Miao, Lizhi Zhang, Jian Zhou
Summary: Dissipative particle dynamics simulations were used to study the stability and drug loading/release behaviors of unimolecular micelles formed using PAMAM(G5)-PCBMA. The results indicated that PAMAM(G5)-PCBMA can form core-shell unimolecular micelles capable of loading and releasing DOX, exhibiting regularities with drug concentration changes. Comparisons with PAMAM(G5)-PEGMA system showed better monodisperse stability in the former. This work could provide theoretical guidance for the design and development of promising unimolecular micelles for drug delivery.
Article
Engineering, Multidisciplinary
Quynh Hoang Le, Fathallah Neila, Kamel Smida, Zhixiong Li, Zahra Abdelmalek, Iskander Tlili
Summary: This study investigates the adsorption and release behavior of doxorubicin (DOX) drugs in graphene oxide (GO) nanocarriers compared to pure graphene using molecular dynamics simulations. The results demonstrate the superior adsorption and releasing abilities of DOX in GO nanocarriers, highlighting the advantages of GO in drug delivery systems. The presence of oxygenated functional groups on GO enhances drug loading efficiency and stability, while the pH-responsive behavior of GO enables controlled drug release triggered by the acidic tumor environment.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Oncology
Jian Song, Bingbing Xu, Hui Yao, Xiaofang Lu, Yang Tan, Bingyang Wang, Xing Wang, Zheng Yang
Summary: The study demonstrated a pH-responsive PEGylated doxorubicin prodrug that could achieve high drug loading and pH-responsive drug release within tumor cells, with good stability. Furthermore, the nanoparticles showed similar cytotoxicity to MCF-7 tumor cells as free DOX drug, and were able to encapsulate small DOX drugs with enhanced therapeutic effects.
FRONTIERS IN ONCOLOGY
(2021)
Article
Polymer Science
Arjaree Jobdeedamrong, Man Theerasilp, Nutthanit Thumrongsiri, Paweena Dana, Nattika Saengkrit, Daniel Crespy
Summary: In this study, GSH-responsive and self-immolative polyprodrug nanoparticles were prepared for cancer treatment. These nanoparticles showed high drug loading and efficient redox-responsive release, displaying high cytotoxicity against cancer cells and low cytotoxicity against cancer cells treated with GSH scavenger or normal cells.
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Hui Zhang, Huan Wang, Baojie Wen, Ling Lu, Yuanjin Zhao, Renjie Chai
Summary: This study presents a novel conductive silk conduit composed of poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS) composites and ultrasound (US)-triggered active release system for peripheral nerve regeneration. The silk fibroin conduits demonstrate excellent biocompatibility, flexibility, conductivity, and bioactivity. The US-triggered release of nerve growth factor (NGF) from the secondary filling hydrogel, along with the electrical conductivity of PEDOT:PSS, accelerates the repair of injured nerves, as demonstrated by in vivo experiments. These intelligent conductive silk conduits with US responsiveness show practical value for nerve regeneration in preclinical studies.
Article
Pharmacology & Pharmacy
Fen Zhang, Qian Yao, Xiaoqi Chen, Haijun Zhou, Mengmeng Zhou, Yantao Li, Hua Cheng
Summary: The post-encapsulation and release of the anticancer drug doxorubicin hydrochloride (DOX·HCl) through the cell-like transmission functions of polymeric vesicles were investigated. Ethylenediamine-modified cross-linked pH-responsive polymeric vesicles were fabricated for the first time using redox-initiated reversible addition-fragmentation chain transfer dispersion polymerization. The vesicles showed a pH-dependent open and closed state, and exhibited a faster release rate of DOX at pH 5.0 compared to pH 6.5. The DOX-loaded vesicles had low cytotoxicity and higher cellular uptake capability compared to free DOX.
Article
Pharmacology & Pharmacy
Fatima Fernandez-Alvarez, Gracia Garcia-Garcia, Jose L. Arias
Summary: The study successfully constructed a maghemite/PLGA/chitosan nanostructure with good stability, magnetism, and drug release behavior, showing significant anti-lung adenocarcinoma effect of cisplatin loading on the matrix.
Article
Mathematics, Interdisciplinary Applications
David Kaplan, Jianshen Chen, Sinan Yavuz, Weicong Lyu
Summary: The purpose of this paper is to demonstrate and evaluate the use of Bayesian dynamic borrowing in large-scale educational assessments. The results show that Bayesian dynamic borrowing performs well in cases with heterogeneous historical data compared to other methods, while it performs similarly to other methods in cases of homogeneous data.
Article
Neurosciences
Dustin M. Snapper, Bianca Reginauld, Volha Liaudanskaya, Vincent Fitzpatrick, Yeonho Kim, Irene Georgakoudi, David L. Kaplan, Aviva J. Symes
Summary: This study developed a novel approach to studying traumatic brain injury caused by primary blast and utilized a bioengineered 3D brain-like human tissue culture system to simulate blast wave effects. The findings showed cellular injury, axonal varicosities, and the release of known biomarkers after blast.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Constancio Gonzalez-Obeso, Emily Jane Hartzell, Ryan Albert Scheel, David L. Kaplan
Summary: Effective drug delivery is crucial for successful medical treatment. Silks and recombinant silks have emerged as preferred polymeric drug delivery systems due to their unique properties and tailored physicochemical characteristics.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Shengfei Zhou, Kai Jin, Talia Khan, Zaira Martin-Moldes, David L. Kaplan, Markus J. Buehler
Summary: More complex bioadhesives were investigated, and the physical properties of the adhesive were improved through cold denaturation and swelling. This resulted in enhanced mechanical performance and water resistance of wood composites.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Multidisciplinary Sciences
Maobin Xie, Liming Lian, Xuan Mu, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Zhenrui Zhang, Arturo Lopez, Jennifer Manriquez, Xiao Kuang, Junqi Wu, Jugal Kishore Sahoo, Federico Zertuche Gonzalez, Gang Li, Guosheng Tang, Sushila Maharjan, Jie Guo, David L. Kaplan, Yu Shrike Zhang
Summary: This study demonstrates the rapid volumetric printing of unmodified silk sericin and silk fibroin inks, which exhibit shape-memory and tuneable mechanical properties. The inks are cytocompatible, providing expanded bioink libraries for volumetric additive manufacturing and offering potential for diverse biomedical applications.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Jaewon Choi, Jugal Kishore Sahoo, Onur Hasturk, Thomas Falcucci, Ya Yao, David L. Kaplan
Summary: This study presents a new strategy to fabricate silk protein-based aerosols and silk fibers instantaneously in situ using a spray device, without the need for complicated and costly advanced manufacturing techniques. The key to success lies in the conformational transition of silk fibroin from random coil to beta-sheet before spraying, achieved by mixing silk and polyethylene glycol solutions in the spray device. The system utilizes green solvents and shear and elongational flow to provide a portable and user-friendly method for drug delivery carriers and surface coatings.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Andrew J. Stout, Miriam L. Rittenberg, Michelle Shub, Michael K. Saad, Addison B. Mirliani, James Dolgin, David L. Kaplan
Summary: The development of cost-effective serum-free media is crucial for the economic viability of cultured meat. This study successfully replaced recombinant albumin, which is a high-cost component, with rapeseed protein isolate in a serum-free medium called Beefy-R. The new medium showed improved growth and maintained cell phenotype and myogenicity of bovine satellite cells, offering a sustainable and low-cost alternative for muscle stem cell culture in cultured meat production.
Review
Biotechnology & Applied Microbiology
Ying Pei, Wen Yang, Keyong Tang, David L. Kaplan
Summary: Collagen presents a hierarchical multilevel structure that achieves an ideal balance of mechanical strength and toughness. Isolation of mesostructured aggregates of collagen from biological tissues enables the construction of new collagen materials with ideal mechanical performance. The use of these mesostructural components has shown promise in various applications.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Applied
Qiongling Chen, Jinchuang Zhang, Yujie Zhang, Haodong Liu, Tongqing Li, Qiang Wang, David L. Kaplan
Summary: This study investigated the interactions between pea protein and fatty acids as well as the effect on protein conformational changes during high-moisture extrusion processing. The results showed that fatty acids induced the exposure of hydrophobic groups, weakened hydrogen bonds, and affected the aggregation of protein subunits. Unsaturated fatty acids limited protein chain refolding and covalent interactions. Additionally, stearic acid promoted the formation of fibrous structures.
Article
Engineering, Biomedical
Zhaozhao Ding, Weinan Cheng, Lutong Liu, Gang Xu, Qiang Lu, David L. Kaplan
Summary: Inspired by metal-organic frameworks, silk-magnesium ion complexes are formed using nanosized silk protein aggregates with a high negative charge density. The magnesium ions are added directly to the silk nanoparticle solutions, inducing gelation through silk-magnesium coordination complexes. The slow release of magnesium ions from the nanoparticles through diffusion and the tunable degradation or dissolution of the nanosized silk aggregates enable sustained release and dose-dependent effects on angiogenic and anti-inflammatory functions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Marta G. Fuster, Mercedes G. Montalban, Imane Moulefera, Gloria Villora, David L. Kaplan
Summary: In this study, folic acid-conjugated silk nanoparticles were used to deliver the anticancer drug ibrutinib (IB) to cancer cells with folate receptor overexpression. The study confirmed that the functionalized nanoparticles were internalized by cancer cells, mediated by folate receptors. This suggests that the developed nanocarrier can enhance IB uptake in cancer cells and be used for drug targeting applications.
Review
Chemistry, Multidisciplinary
Jugal Kishore Sahoo, Onur Hasturk, Thomas Falcucci, David L. Kaplan
Summary: Silk fibroin is widely used in various medical fields such as tissue engineering, regenerative medicine, drug delivery, and medical devices. Advancements in silk chemistry and biomaterial designs have resulted in exciting tools for creating new silk-based materials and technologies. Selective chemistries can enhance or modify the properties of silk to address challenges in medically relevant materials.
NATURE REVIEWS CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Kirsten R. Trinidad, Reina Ashizawa, Amin Nikkhah, Cameron Semper, Christian Casolaro, David L. Kaplan, Alexei Savchenko, Nicole Tichenor Blackstone
Summary: Growth factors are critical components in cultivated meat production, but their environmental impacts have not been accurately quantified in current assessments. This study conducted a life cycle assessment to evaluate the environmental impacts of recombinant growth factor production for cultivated meat applications. The results show that even in small quantities, recombinant growth factors can have significant environmental impacts. Future research should explore sustainable production methods or alternative options with lower environmental impacts.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Materials Science, Biomaterials
Gang Xu, Liying Xiao, Peng Guo, Yuanyuan Wang, Shiyu Ke, Guozhong Lyu, Xiangsheng Ding, Qiang Lu, David L. Kaplan
Summary: The study developed an assembly strategy to regulate multiple cues in the same scaffold. The results showed that the multiple cues in the scaffold could promote vascularization and accelerate wound healing.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Atul Sharma, Cihan Asci, Ruben Del-Rio-Ruiz, Kirsten Trinidad, Nafize Ishtiaque Hossain, David L. Kaplan, Sameer Sonkusale
Summary: A portable and scalable multiplexed thread-based sensing microprobe is introduced for continuous monitoring of pH and ammonium ions during the biofermentation process. The microprobe consists of a 3D-printed shell to hold separate working and reference electrode threads, allowing for continuous flow during monitoring. The functionality of the microprobe is evaluated in a simulated microreactor resembling a fermentation environment, showing promising dynamic range for pH and ammonium ions in bioreactor monitoring.
IEEE SENSORS LETTERS
(2023)