Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Chemistry, Analytical
Ziqi Li, Weimin Wan, Ziwei Bai, Bo Peng, Xi Wang, Liu Cui, Zhaoyun Liu, Kui Lin, Jian Yang, Jia Hao, Fei Tian
Summary: Currently, developing responsive hydrophobic drug delivery systems centered on magnetic nanoparticles is a promising approach for efficient drug delivery to living cells. In this study, a pH-responsive nanoplatform for targeted hydrophobic drug delivery was successfully constructed using a SET-LRP method. The nanoplatform showed high biocompatibility and low cytotoxicity, and exhibited pH-responsive release behaviors under different pH values. Furthermore, it effectively targeted and inhibited the growth of HepG2 cells, and allowed for continuous intracellular imaging. These findings represent a significant advancement in the field of clinical hydrophobic drug delivery platforms.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biophysics
Priyanka Ray, Narendra Kale, Mohiuddin Quadir
Summary: Novel molecular motifs act as pH-regulating triggers for amphiphilic, pH-sensitive block copolymers, enhancing their self-assembling properties and potential for drug delivery systems.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Hai-Yan Wang, Yan Zhang, Xing-Hui Ren, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: In this study, a biocompatible, tumor-targeted nanoplatform (HIDSi(Gd)NPs@PDA-HA) based on HMONs was developed for accurate tumor-targeting and synergistic therapy. The nano-carrier promoted endocytosis in cancer cells, released DOX in response to tumor microenvironment, and utilized ICG for photothermal therapy, achieving multi-mode imaging-guided therapy. The results in tumor-bearing mice demonstrated excellent therapeutic efficacy, indicating the potential of this multifunctional nanomaterial for precise diagnosis and efficient treatment.
Article
Pharmacology & Pharmacy
Minja Mladenovic, Ibrahim Morgan, Nebojsa Ilic, Mohamad Saoud, Marija V. Pergal, Goran N. Kaluderovic, Nikola Z. Knezevic
Summary: Ruthenium complexes with potent cytotoxic activity are being studied for cancer treatment, with a focus on constructing drug delivery systems using mesoporous silica nanoparticles functionalized with pH-responsive ligands to enhance the release of Ru(II) complexes in tumor acidic environments. In vitro evaluations on metastatic melanoma cells demonstrate the promising pH-responsive delivery of metallotherapeutics and targeted treatment of cancer using these designed MSN nanocarriers.
Review
Chemistry, Multidisciplinary
Ali Pourjavadi, Rozhin Heydarpour, Zahra Mazaheri Tehrani
Summary: Multi-stimuli-responsive hydrogels have gained increased attention for their tunable changes in swelling or mechanical properties in physiological states. They are widely used in medical applications, with a focus on self-healing hydrogels, anti-bacterial materials, and drug-delivery systems.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Dan Xu, Tiantian Jin, Lijun Song, Ning Zhu, Limin Han, Hailong Hong
Summary: The construction of controlled release for drugs is a promising strategy in disease treatment, which can improve the bioavailability of utilized drugs and reduce the side effects. A simple and green strategy was developed to prepare stable amorphous calcium carbonate (ACC) using polyvinyl pyrrolidone (PVP) as stabilizer. The obtained ACC-PVP exhibited high drug loading efficiency and pH responsive release properties for anticancer drugs 5-Fluorouracil (5-FU) and curcumin (CUR) in phosphate buffer solution and simulated gastric juice.
Article
Pharmacology & Pharmacy
Huiru Zhu, Li Kong, Xu Zhu, Tingting Ran, Xiaojuan Ji
Summary: This study successfully constructed pH-responsive nanoparticles that can precisely release anti-proliferative drug PTX and pH-sensitive agent NaHCO3. These nanoparticles demonstrated good pH sensitivity and safety in both in vitro and in vivo experiments. In a rat model, they effectively suppressed intimal proliferation.
Article
Materials Science, Multidisciplinary
Yuqi Liu, Shengzhen Li, Chuanyang Ding, Zhangjie Ge, Abida Aierken, Jiamin Li, Liying Qin, Jiayi Liu, Xiaolong Guo, Yixi Wang, Zhankui Xing, Fusong Yuan, Ping Zhou
Summary: A novel nanomaterial was synthesized, which can achieve targeted killing and dual-responsive release in tumor cells, showing significant therapeutic value for tongue squamous cell carcinoma.
MATERIALS & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Article
Nanoscience & Nanotechnology
Maximilian A. Beach, Serena L. Y. Teo, Moore Z. Chen, Samuel A. Smith, Colin W. Pouton, Angus P. R. Johnston, Georgina K. Such
Summary: Nanoparticles have the potential to revolutionize drug delivery, but overcoming endosomal escape remains a significant challenge. Recent research focuses on designing nanoparticles that can escape endosomes in response to biological stimuli such as pH changes, which can improve drug delivery efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Rachel Yie Hang Tan, Choy Sin Lee, Mallikarjuna Rao Pichika, Sit Foon Cheng, Ki Yan Lam
Summary: This review summarizes the applications of pH-responsive polyurethane in the biomedical and drug delivery fields in recent years, including controlled drug delivery systems for oral administration, intravaginal administration, and targeted drug delivery systems for chemotherapy treatment. Additionally, it discusses other applications such as surface biomaterials, sensors, and optical imaging probes.
Article
Engineering, Chemical
Dan-Na Hu, Xiao-Jie Ju, Xing-Qun Pu, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: The copolymer Alg-g-PNA shows temperature and glucose responsiveness, with the ability to transition between sol and gel states for insulin delivery based on environmental conditions. Additionally, the hydrogels demonstrate good biocompatibility and reversible sol-gel transitions in response to changes in blood glucose levels, making them a promising option for self-regulating insulin delivery in diabetes therapy.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yun Liu, Yanfang Wang, Yuejun Yao, Juan Zhang, Wei Liu, Kangfan Ji, Xinwei Wei, Yuanwu Wang, Xiangsheng Liu, Shiming Zhang, Jinqiang Wang, Zhen Gu
Summary: Lipid nanoparticle-based drug delivery systems have a significant impact on nucleic acid-based therapy and vaccination. We designed phenylboronic acid-based quaternary amine-type cationic lipids that can self-assemble into spherical lipid nanoparticles. Mixing insulin with the lipid nanoparticles immediately forms a heterostructured insulin complex, and in a hyperglycemia-relevant glucose solution, the lipid nanoparticles gradually become less positively charged, leading to insulin release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Zhongtao Li, Jing Guo, Guiqiang Qi, Meng Zhang, Liguo Hao
Summary: A pH-responsive and imaging nanocarriers system using mesoporous silica nanoparticles (MSNs) doped with gadolinium (Gd) was developed. The system showed pH-responsiveness and high biocompatibility, and the T1 contrast was significantly enhanced by Gd, making it a promising system for cancer diagnosis and treatment.
Article
Chemistry, Applied
Qi Li, Yuehan Wu, Mohd Shabbir, Ying Pei, Hongshan Liang, Jing Li, Yijie Chen, Yan Li, Bin Li, Xiaogang Luo, Shilin Liu
Summary: O/W Pickering emulsions containing oil phase with different volume fractions were prepared using bacterial cellulose nanofibrils (BCNFs) alone. The emulsions exhibited excellent physical stability and low coalescence rate, with droplet size varying from 32 to 91 μm. Increasing particle contents decreased droplet size and enhanced emulsion stability.
Article
Agriculture, Multidisciplinary
Yan Hu, Fei Liu, Junxiao Pang, David Julian McClements, Zhiqin Zhou, Bin Li, Yan Li
Summary: The research showed that encapsulating tangeretin in emulsions can enhance its oral bioavailability, with the addition of HPMC having the most significant effect.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Physical
Gege Sun, XiaoKe Liu, David Julian McClements, Shilin Liu, Bin Li, Yan Li
Summary: This study investigated the use of chitin nanofibers (ChNFs) to improve the pH stability of Pickering emulsions formed from zein colloidal particles (ZCPs), enhancing the contact angle and stability of the emulsions while reducing lipolysis of oil droplets. By forming electrostatic complexes between ChNFs and ZCPs, the aggregation tendencies of ZCPs at pH values near or greater than their isoelectric point were minimized, leading to better emulsion stability.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Food Science & Technology
Yunxiao Xie, Yujie Lei, Jianhua Rong, Xingzhong Zhang, Jing Li, Yijie Chen, Hongshan Liang, Yan Li, Bin Li, Zhicai Fang, Xiaogang Luo, Ying Pei, Chunyan Zhong, Shilin Liu
Summary: This study evaluated the potential of oil-in-water Pickering emulsions stabilized with dietary fibers as fat substitutes in low-calorie baked foods. The findings showed that the biscuits had better appearance and texture with a 35% fat replacement rate. This research expands the potential application of Pickering emulsions stabilized with dietary fibers in the development of low-fat baked foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Qi Li, Yilan Wu, Rongxi Fang, Chan Lei, Yan Li, Bin Li, Ying Pei, Xiaogang Luo, Shilin Liu
Summary: This article discusses the application and stabilization mechanism of nanocellulose-based Pickering emulsions in the food industry. Nanocellulose effectively stabilizes emulsions by adsorbing to oil-water interfaces and forming three-dimensional networks, with wide potential applications in food-grade products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Microbiology
Yi Li, Runan Zhao, Yan Li, Zhiqin Zhou
Summary: A nanoemulsion containing limonene was prepared to combat citrus blue mold caused by Penicillium italicum. The nanoemulsion disrupted the integrity of the pathogenic fungus's cell membrane and inhibited its ability to infect citrus fruits, showing promising antifungal activity.
Article
Chemistry, Applied
Yuxing Gao, Yujie Lei, Yuehan Wu, Hongshan Liang, Jing Li, Ying Pei, Yan Li, Bin Li, Xiaogang Luo, Shilin Liu
Summary: The study successfully fabricated stable food-grade water-in-oil emulsions using a facial method at 20 degrees C, with long-term stability and no phase separation. Beeswax was utilized as a stabilizer in the system, regulating the beeswax content to produce emulsions with a droplet diameter of around 9 μm. These surfactant-free emulsions show great potential applications in the food, pharmaceutical, and feed industries.
Article
Chemistry, Applied
Runan Zhao, Weiting Fu, Yijie Chen, Bin Li, Shilin Liu, Yan Li
Summary: The study investigated the effect of CA on WPI, showing that the WPI/CA complex can act as a stabilizer to form emulsions and emulsion gels for better protection and enhanced bioaccessibility of beta-carotene. The findings provide insights into developing new multifunctional food ingredients and improving protein modification in food systems.
Article
Food Science & Technology
Runan Zhao, Yu Zhang, Huanle Chen, Rong Song, Yan Li
Summary: A green chitosan-based coating was prepared by incorporating chitosan-stabilized eugenol emulsions into chitosan solution. The coating significantly improved the performance of chitosan, including anti-corrosion, UV-light resistance, and water vapor permeability. It also extended the shelf-life of fresh meat.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Food Science & Technology
Rongxi Fang, Hongshan Liang, Jing Li, Yijie Chen, Xiaogang Luo, Yan Li, Bin Li, Shilin Liu
Summary: This study developed a novel encapsulation system for producing astaxanthin (AXT)-loaded microcapsules using emulsion solvent evaporation and spray-dried methods. The resulting microcapsules exhibited excellent physical stability and potential applications for AXT.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Bing Cui, Yingyi Mao, Hongshan Liang, Yan Li, Jing Li, Shuxin Ye, Wenxin Chen, Bin Li
Summary: This study presents a method to fabricate an analogue of pork backfat using a combination of emulsion and gel. By using soybean protein isolate and curdlan, an emulsion gel was prepared and its microstructures, rheology properties, water holding capacity, and freeze-thawing stability were investigated. The results showed that the emulsion gel was thermal irreversible and the oil content significantly affected its water holding capacity and freeze-thawing stability. Compared with pork backfat, the emulsion gel with 10 wt% oil content exhibited no significant differences in hardness, chewiness, springiness, and gel strength.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Qian Shen, Ting Xiong, Jun Dai, Xi Chen, Ling Wang, Yan Li, Jing Li, Bin Li, Yijie Chen
Summary: The alkali pH-shifting treatment improved the emulsifying capacity of pea protein isolates (PPI). This study further investigated the mechanism by determining the relative quantities and types of inter-facial adsorbed proteins through quantitative proteomic. The results showed that the pH 10-shifting treatment increased the relative quantities of legumins and albumins at the oil-water interface, while the relative abundances of vicilins decreased. These findings contribute to the potential development of theory of plant protein stabilized emulsions.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Yingzhu Zhang, Jinqi Xu, Cuie Tang, Yan Li
Summary: The concentration effects of fatty acid glycerides on the crystallization behavior and physical properties of oleogels were investigated. Saturated fatty acid glycerides (GMS, GML, GMC) formed solid-like and thermally reversible oleogels, while a higher amount of unsaturated fatty acid glycerides (GMO, GDO) were needed. The oleogels based on GMS and GMC had higher crystallinity, resulting in higher thermal stability and better mechanical properties than GML-based ones.
Article
Chemistry, Applied
Chunxiang Zhang, Yuxing Gao, Yilan Wu, Zhiliang Zheng, Yunxiao Xie, Yan Li, Bin Li, Ying Pei, Shilin Liu
Summary: Oil-in-water-in-oil (O/W/O) multiple emulsions were fabricated using carboxymethyl chitosan to stabilize the O/W emulsion as the inner dispersed phase and beeswax as the external oil phase. The study investigated the effects of beeswax content and volume fraction of the inner O/W emulsion on the morphology, stability, and rheological properties of the O/W/O multiple emulsions. Increasing the beeswax content improved the stability and viscosity of the O/W/O multiple emulsions.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Yingzhu Zhang, Ying Yang, Yingyi Mao, Yanrong Zhao, Xiang Li, Junjie Hu, Yan Li
Summary: This study investigates the effects of polar lipids (MDG and PL) on the bioaccessibility of lipophilic nutrients using a protein-based emulsion model system. The results show that the incorporation of MDG/PL benefits the dissolution and stabilization of lipophilic nutrients, improving their bioaccessibility. The use of MDG/PL also modifies the construction of the emulsion surface and decreases the interfacial tension. In vitro and cell culture experiments further demonstrate the effectiveness of MDG/PL in improving the absorption of lipophilic nutrients.
