Article
Gastroenterology & Hepatology
Shogo Tanaka, Hiroji Shinkawa, Akihiro Tamori, Shigekazu Takemura, Sawako Uchida-Kobayashi, Ryosuke Amano, Kenjiro Kimura, Go Ohira, Kohei Nishio, Jun Tauchi, Masahiko Kinoshita, Norifumi Kawada, Shoji Kubo
Summary: A study examined the effects of direct-acting antiviral (DAA)-induced sustained virological response (SVR) in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) after liver resection. While DAA-induced SVR itself may not suppress postoperative recurrence, the study found that DAA treatment improved liver function and prolonged postoperative survival in patients.
HEPATOLOGY RESEARCH
(2021)
Article
Virology
Shou-Wu Lee, Li-Shu Chen, Sheng-Shun Yang, Yi-Hsiang Huang, Teng-Yu Lee
Summary: In patients with BCLC stage B/C HCC, DAA therapy can achieve a high SVR rate, except for those with PD to prior HCC treatments. SVR is related to improvements in OS, therefore, DAA therapy should be encouraged for patients diagnosed without a short life expectancy.
Article
Oncology
Mohamed Saleh Ismail, Islam Mohamed, Efstathia Polychronopoulou, John A. Goss, Yong-Fang Kuo, Fasiha Kanwal, Prasun K. Jalal
Summary: Liver transplant recipients in the IFN-free DAA treatment era had significantly higher rates of complete tumor necrosis in the explants. Other HCC tumor characteristics were similar between the two eras. Post-LT graft failure rates at 1 and 3 years significantly decreased in the IFN-free DAA treatment era among patients with HCV and HCC, although patient mortality rates were not significantly different.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Review
Medicine, General & Internal
Muhammad Nauman Zahid
Summary: There is concern about using organs from HCV-positive donors for transplantation. However, direct-acting antiviral drugs have been proven to effectively treat Hepatitis C in transplant patients. This review will examine the impact of DAA treatments on transplants of different organs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Aline Lopes Chagas, Angelo A. Mattos, Marcio A. Diniz, Guilherme E. G. Felga, Ilka F. S. F. Boin, Rita C. M. A. Silva, Renato F. Silva, Jose H. P. Garcia, Agnaldo S. Lima, Julio C. U. Coelho, Paulo L. Bittencourt, Venancio A. F. Alves, Luiz Augusto Carneiro D'Albuquerque, Flair J. Carrilho
Summary: The study evaluated post-OLT outcomes in 1059 liver transplant recipients with HCC in Brazil, finding satisfactory overall survival and recurrence rates for patients within MC. BMC showed lower performance in predicting recurrence risk. Future discussions may involve revisiting the criteria currently used.
ANNALS OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Saleh A. Alqahtani, Massimo G. Colombo
Summary: The prevalence and burden of hepatitis C virus (HCV) in children are poorly understood. Vertical transmission and injection drug use are the main modes of infection. Early diagnosis and treatment are crucial in preventing HCV-induced severe liver disease. Direct-acting antiviral drugs have shown to be as safe and effective in young HCV patients as in adults.
LIVER INTERNATIONAL
(2021)
Article
Surgery
Marion G. Peters, Shyam Kottilil, Norah Terrault, Dominic Amara, Jennifer Husson, Shirish Huprikar, Sander Florman, Mark S. Sulkowski, Christine M. Durand, Anne F. Luetkemeyer, Rodney Rogers, Joshua Grab, Brandy Haydel, Emily Blumberg, Lorna Dove, Jean Emond, Kim Olthoff, Coleman Smith, Thomas Fishbein, Henry Masur, Peter G. Stock
Summary: The study demonstrates that sofosbuvir-based DAA therapy is safe and highly effective for HCV-HIV coinfected patients with decompensated liver disease and post-liver transplant, with post-transplant survival rates comparable to other indications, removing a significant barrier to liver transplantation in this challenging cohort of recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Stephan R. Marticorena Garcia, Christian E. Althoff, Michael Duerr, Fabian Halleck, Klemens Budde, Ulrike Grittner, Christian Burkhardt, Korinna Joehrens, Juergen Braun, Thomas Fischer, Bernd Hamm, Ingolf Sack, Jing Guo
Summary: This study longitudinally evaluated changes in viscoelasticity of the liver and kidney allografts in kidney transplant recipients with HCV infection after treatment with direct-acting antiviral agents. The results showed that hepatic stiffness and fluidity decreased while kidney allograft stiffness and fluidity increased post-treatment, indicating restoration of mechanically sensitive structures and functions in both organs. Tomoelastography may be used non-invasively to monitor the therapeutic results of HCV treatment based on hepatic and renal viscoelastic parameters.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yu Jun Wong, Prem Harichander Thurairajah, Rahul Kumar, Kwong Ming Fock, Ngai Moh Law, Sin-Yoong Chong, Fria Gloriba Manejero, Tiing-Leong Ang, Eng Kiong Teo, Jessica Tan
Summary: This retrospective study in incarcerated HCV-infected patients in Singapore showed that unrestricted access to DAA significantly increased treatment access, completion rate, and reduced treatment default rate, highlighting the impact of this strategy in HCV micro-elimination efforts.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Review
Virology
Christopher Dietz, Benjamin Maasoumy
Summary: Hepatitis C virus infection poses a significant threat to human health, but the development of specific antiviral drugs has revolutionized the treatment and brought hope to patients.
Article
Gastroenterology & Hepatology
Anjiya Shaikh, Karthik Goli, Tzu-Hao Lee, Nicole E. Rich, Jihane N. Benhammou, Stephanie Keeling, Donghee Kim, Aijaz Ahmed, John Goss, Abbas Rana, Amit G. Singal, Fasiha Kanwal, George Cholankeril
Summary: This study evaluated the impact of direct-acting antiviral (DAA) availability on racial and ethnic disparities in post-liver transplant (LT) survival for black patients with hepatocellular cancer (HCC). The results showed that in the DAA era, black patients had comparable 3-year survival to white patients, indicating an improvement in racial disparities with the availability of DAA therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Yun-Cheng Hsieh, Kuei-Chuan Lee, Chien-Wei Su, Ken-Hsin Lan, Teh-Ia Huo, Yuan-Jen Wang, Hui-Chun Huang, Han-Chieh Lin, Chi-Jen Chu, Yi-Hsiang Huang, Ming-Chih Hou
Summary: The study found that persistent elevation of aminotransferase levels is not uncommon in patients with advanced fibrosis after DAA treatment, and it is associated with impaired baseline liver function and steatosis. Long-term follow-up is needed to assess the impact of liver inflammation on disease progression.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ming-Lun Yeh, Ching- Huang, Po-Cheng Liang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Shang-Jyh Hwang, Wan-Long Chuang, Chung-Feng Huang, Yi-Wen Chiu, Ming-Lung Yu
Summary: HCV-viremic patients on hemodialysis have a high prevalence of comedications with various potential drug-drug interactions (DDIs) with available DAA regimens. Elbasvir/grazoprevir has the fewest potential DDIs, while sofosbuvir/velpatasvir/voxilaprevir has the most potential DDIs among the analyzed regimens.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Puneeta Tandon, Alberto Zanetto, Salvatore Piano, Julie K. Heimbach, Srinivasan Dasarathy
Summary: Frailty is a decline in functional reserve across multiple physiological systems, with key components being sarcopenia and physical frailty. These conditions are common in liver transplant candidates and have been shown to adversely impact clinical outcomes. The liver frailty index and cross-sectional image analysis of muscle area are used to assess physical frailty and sarcopenia, respectively. Nutritional interventions and physical activity are important management strategies, but there is a need for more large-scale trials. It is also recognized that a multidisciplinary approach is necessary to address the various components of frailty in transplant candidates.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Young-Hwan Ahn, Heirim Lee, Do Young Kim, Hye Won Lee, Su Jong Yu, Young Youn Cho, Jeong Won Jang, Byoung Kuk Jang, Chang Wook Kim, Hee Yeon Kim, Hana Park, Hyo Jung Cho, Bumhee Park, Soon Sun Kim, Jae Youn Cheong
Summary: This study evaluated the efficacy of DAA therapy in Korean patients with HCV-related HCC and found a correlation between short last HCC treatment duration and HCC recurrence. The results suggest that the last HCC treatment duration is an important predictor of HCC recurrence after DAA therapy.
