Article
Biochemistry & Molecular Biology
Kangping Liu, Hongfan Ge, Chengyin Liu, Yixin Jiang, Yaling Yu, Zhenlei Zhou
Summary: This study aimed to investigate the role of the differentiation of bone marrow mesenchymal stem cells (BMSCs) in the development of femoral head necrosis (FHN). The results showed that BMSCs isolated from FHN-affected broilers demonstrated enhanced lipogenic differentiation, activated Notch-RBPJ signaling pathway, and diminished osteogenic and chondrogenic differentiation. Treatment with methylprednisolone (MP) decreased the expressions of Runx2, BMP2, Col2a1, and Aggrecan, while increased the expressions of p-Notch1/Notch1, Notch2, and RBPJ. Jagged-1 (JAG-1)/DAPT could promote/inhibit the osteogenic or chondrogenic ability of MP-treated BMSCs, respectively, and the differentiation ability of BMSCs was restored after transfection with si-RBPJ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yuanwu Cao, Chang Jiang, Xinyuan Wang, Hao Wang, Zuoqin Yan, Hengfeng Yuan
Summary: The study found that miR-224-5p was upregulated in GC-treated BMSCs, regulating the adipogenic and osteogenic differentiation of BMSCs by inhibiting Smad4 and activating the Smad4-Taz axis. The miR-224-5p antagomir could alleviate the inhibitory effects of GCs and promote bone formation in steroid-induced ONFH models, suggesting it as a potential novel therapeutic target for this condition.
Article
Biotechnology & Applied Microbiology
Senlin Chai, Jianhao Huang, Abdurahman Mahmut, Bin Wang, Yao Yao, Xiaofeng Zhang, Zaikai Zhuang, Chunmei Xie, Zhihong Xu, Qing Jiang
Summary: The research team developed a photo-crosslinked composite bioactive scaffold based on GelMA, BMSCs, and BMP2, which showed good adaptability and osteogenic potential in vitro and in vivo, indicating its potential application in bone regeneration and bone defect repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Jianmin Liu, Ming Chen, Longyang Ma, Xingbo Dang, Gongliang Du
Summary: The study revealed that piRNA-36741 promotes osteogenic differentiation of BMSCs by regulating METTL3-mediated m6A methylation of BMP2 transcripts. This provides insights into the mechanisms of osteogenic differentiation regulation and offers new perspectives for bone disease treatment.
Article
Pharmacology & Pharmacy
Qian Liu, Yuyang Wu, Sisi Li, Somy Yoon, Jiaxin Zhang, Xiaoyi Wang, Luoshuang Hu, Chenying Su, Chunwu Zhang, Yungang Wu
Summary: Steroid-induced avascular necrosis of femoral head (SANFH) is a common and disabling disorder worldwide, commonly caused by overdosing on glucocorticoid. The therapeutic strategies for SANFH are limited and the underlying mechanisms are still not well understood. However, osteogenic dysfunction involving apoptosis and differentiation disorder of bone marrow mesenchymal stem cells (BMSCs) is considered a crucial pathobiological mechanism in SANFH development. Ursolic acid (UA), a component of the Chinese medicine Yougui Yin, has various pharmacological properties and our study suggests that UA has potential for treating SANFH by promoting BMSCs proliferation, inhibiting apoptosis, and enhancing osteogenic differentiation.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Ke Rong, Xiaoliu Li, Weimin Jiang, Xuhua Wu, Qingquan Xia, Jie Chen, Xiaofan Yin
Summary: This study investigated the potential protective effects of Alendronate in the early stage of femur head necrosis and showed that Alendronate might treat ONFH by targeting the BMP2/EIF2AK3/EIF2A/ATF4 pathway, as revealed by experimental results.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Penghui Bu, Weipeng Xie, Sicheng Wang, Zhi Yang, Kan Peng, Weisong Zhang, Shouye Hu
Summary: In this study, EGFL6 was found to play a protective role in SONFH by promoting osteogenesis and angiogenesis of BMSCs, potentially through activation of ERK1/2. The downregulation of EGFL6 in SONFH patients led to weaker bone repair abilities, which were improved by EGFL6 overexpression.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qiuyang Zhang, Li Zhang, Minhui Yang, Qingxiang Hong, Zhongmei Yang, Sen Liu, Qingping Xiong, Changjiang Pan
Summary: By constructing a multifunctional composite coating on AZ31B magnesium alloy surface, the study successfully enhanced the hydrophilicity and corrosion resistance of the material, improved biocompatibility, and inhibited infections caused by Escherichia coli (E. coli).
NANOTECHNOLOGY REVIEWS
(2021)
Article
Cell & Tissue Engineering
Haiyan Wei, Yubao Cui, Zhengjie Liu
Summary: This study investigated the therapeutic effect of BMSCs on femoral head necrosis and whether it can inhibit the growth of OMgP. The results showed that BMSCs transplantation decreased OMgP expression, improved spinal cord injury behavior, repaired the necrotic area of the femoral head, and up-regulated ALP and BGP levels.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
Article
Orthopedics
Masahiro Maruyama, Tzuhua Lin, Nicolas I. Kaminow, Timothy Thio, Hunter W. Storaci, Chi-Chun Pan, Zhenyu Yao, Michiaki Takagi, Stuart B. Goodman, Yunzhi P. Yang
Summary: This study evaluated the efficacy of core decompression for steroid-associated osteonecrosis of the femoral head in rabbits. The results showed that core decompression improved morphological properties but did not significantly improve mechanical strength in the femoral head at early-stage osteonecrosis. Additional biological and mechanical strategies may be needed to enhance the outcomes of early-stage steroid-associated osteonecrosis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Materials Science, Biomaterials
Shibo Huang, Junlei Li, Kairong Qin, Zhiqiang Wang, Jiahui Yang, Fang Cao, Weirong Li, Yupeng Liu, Lipeng Liu, Dewei Zhao
Summary: A CDHA/MgF2 bilayer coating was successfully prepared and shown to reduce the degradation rate and enhance bone formation of HP Mg rods in vivo. The bilayer coating demonstrated good biosafety and improved the properties of HP Mg, providing a basis for future clinical applications.
REGENERATIVE BIOMATERIALS
(2022)
Article
Pharmacology & Pharmacy
Runhong Mei, Dan Chen, Duming Zhong, Guoyong Li, Shaobai Lin, Guangquan Zhang, Kaiyun Chen, Xuefeng Yu
Summary: This study analyzed the metabolic mechanism and effect of Gushiling capsule (GSLC) in the treatment of glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) by establishing the serum metabolite profiles of GSLC in rabbits. The results showed that GSLC regulated the metabolic disorder of endogenous lipid components in GIONFH rabbits and demonstrated anti-GIONFH effects. The findings provide a theoretical basis for further investigating the therapeutic mechanism of GSLC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Multidisciplinary
Fenghe Yang, Chuanping Xu, Wei Zhang, Lei Sun, Guiyu Feng, Tianqin Ning, Wei Wang, Bingbing Sun, Jinyu Li, Xufeng Niu, Yubo Fan
Summary: This study developed novel microspheres for the treatment of early ONFH. The microspheres demonstrated the ability to modulate the tissue healing process and showed promising biological effects in cell experiments and animal models. This research holds great potential for improving the treatment of early ONFH and other bone injuries.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Huijuan Cao, Keda Shi, Jing Long, Yanzhi Liu, Lingli Li, Tianluo Ye, Cuishan Huang, Yuxiao Lai, Xueling Bai, Ling Qin, Xinluan Wang
Summary: This study aimed to analyze the ability of PDGF-BB in preventing destructive repair and promoting reparative osteogenesis in SONFH. After PDGF-BB treatment, more type H vessels and LepR+ MSCs appeared in the affected femoral head, and there was more osteoblastic osteogenesis along the bone surfaces. PDGF-BB treatment prevented the progression of destructive repair and led to 50-70% of osteonecrotic femoral heads undergoing reparative osteogenesis.
Article
Chemistry, Physical
Marcin Kozakiewicz, Izabela Gabryelczak, Bartosz Bielecki-Kowalski
Summary: This study compares the effectiveness of magnesium and titanium in fixation of mandible condylar heads, and found that resorbable metal screws can provide proper and stable treatment results, making them a favored option for osteosynthesis.