Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks

(2016) Anne Schellenberg et al.   Aging-US

Standardization of Good Manufacturing Practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic applications

(2015) Patrick Wuchter et al.   CYTOTHERAPY

Various lamin A/C mutations alter expression profile of mesenchymal stem cells in mutation specific manner

(2015) Anna Malashicheva et al.   MOLECULAR GENETICS AND METABOLISM

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

(2014) Juan Carlos Sepúlveda et al.   STEM CELLS

Mesenchymal Stem/Stromal Cells: A New ''Cells as Drugs'' Paradigm. Efficacy and Critical Aspects in Cell Therapy

(2013) Laura de Girolamo et al.   CURRENT PHARMACEUTICAL DESIGN

Expression profiles of subtracted mRNAs during cellular senescence in human mesenchymal stem cells derived from bone marrow

(2013) Jung Ki Yoo et al.   EXPERIMENTAL GERONTOLOGY

Aging-Related Genes in Mesenchymal Stem Cells: A Mini-Review

(2013) Kyung-Rok Yu et al.   GERONTOLOGY

MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24

(2013) K.-R. Yu et al.   JOURNAL OF CELL SCIENCE

Lamins are rapamycin targets that impact human longevity: a study in centenarians

(2013) G. Lattanzi et al.   JOURNAL OF CELL SCIENCE

Onset of heterogeneity in culture-expanded bone marrow stromal cells

(2013) Matthew J. Whitfield et al.   Stem Cell Research

Assessing Cell and Organ Senescence Biomarkers

(2012) Bruno Bernardes de Jesus et al.   CIRCULATION RESEARCH

Functional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells

(2012) Sven Geißler et al.   PLoS One

Monitoring of cellular senescence by DNA-methylation at specific CpG sites

(2011) Carmen M. Koch et al.   AGING CELL

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

Investigating the purpose of prelamin A processing

(2011) Brandon S. J. Davies et al.   Nucleus

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

(2009) Wolfgang Wagner et al.   PLoS One

Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis

(2009) Jaeyoon Kim et al.   PROTEOMICS

Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts

(2008) Florence Debacq-Chainiaux et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Drugs affecting prelamin A processing: Effects on heterochromatin organization

(2007) Elisabetta Mattioli et al.   EXPERIMENTAL CELL RESEARCH