Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

Muscle-specific microRNAs in skeletal muscle development

(2016) Martin Horak et al.   DEVELOPMENTAL BIOLOGY

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis

(2016) Michael I. Robson et al.   MOLECULAR CELL

CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy

(2016) Charis L Himeda et al.   MOLECULAR THERAPY

Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease

(2016) Marie-Claude Sincennes et al.   Stem Cells Translational Medicine

DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation

(2016) Rhianna C. Laker et al.   Stem Cells International

Somitogenesis: From somite to skeletal muscle

(2015) Giuseppe Musumeci et al.   ACTA HISTOCHEMICA

Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition

(2015) Stephanie C. Weber et al.   CURRENT BIOLOGY

Genetic and epigenetic contributors to FSHD

(2015) Lucia Daxinger et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Alu element-containing RNAs maintain nucleolar structure and function

(2015) M. Caudron-Herger et al.   EMBO JOURNAL

Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways

(2015) Amanda M. Rickard et al.   HUMAN MOLECULAR GENETICS

Myogenesis in the Genomics Era

(2015) Alexandre Blais   JOURNAL OF MOLECULAR BIOLOGY

Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis

(2015) Sami J. Barmada   Neurotherapeutics

Spatial re-organization of myogenic regulatory sequences temporally controls gene expression

(2015) Akihito Harada et al.   NUCLEIC ACIDS RESEARCH

Emerging preclinical animal models for FSHD

(2015) Angela Lek et al.   TRENDS IN MOLECULAR MEDICINE

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

(2015) Shuying Sun et al.   Nature Communications

Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy

(2015) Takako I Jones et al.   Clinical Epigenetics

DNA-binding sequence specificity of DUX4

(2015) Yu Zhang et al.   Skeletal Muscle

Nuclear bodies: new insights into assembly/dynamics and disease relevance

(2014) Judith E Sleeman et al.   CURRENT OPINION IN CELL BIOLOGY

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

(2014) C.-C. Huang et al.   JOURNAL OF CELL SCIENCE

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

(2014) C. F. Sephton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A loss of FUS/TLS function leads to impaired cellular proliferation

(2014) C L Ward et al.   Cell Death & Disease

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

(2014) Darko Bosnakovski et al.   Skeletal Muscle

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells

(2013) Gregory J. Block et al.   HUMAN MOLECULAR GENETICS

Ablation of Promyelocytic Leukemia Protein (PML) Re-patterns Energy Balance and Protects Mice from Obesity Induced by a Western Diet

(2013) Xiwen Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

Immortalized myogenic cells from congenital muscular dystrophy type1A patients recapitulate aberrant caspase activation in pathogenesis: a new tool for MDC1A research

(2013) Soonsang Yoon et al.   Skeletal Muscle

Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism

(2012) Brian A. Keller et al.   ACTA NEUROPATHOLOGICA

Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy

(2012) Hiroaki Mitsuhashi et al.   HUMAN MOLECULAR GENETICS

Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis

(2012) Takako Iida Jones et al.   HUMAN MOLECULAR GENETICS

Pathogenic Considerations in Sporadic Inclusion-Body Myositis, a Degenerative Muscle Disease Associated With Aging and Abnormalities of Myoproteostasis

(2012) Valerie Askanas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

RNA Interference Inhibits DUX4-induced Muscle Toxicity In Vivo: Implications for a Targeted FSHD Therapy

(2012) Lindsay M Wallace et al.   MOLECULAR THERAPY

Effects of Creatine and Its Analog, β-Guanidinopropionic Acid, on the Differentiation of and Nucleoli in Myoblasts

(2011) Yoshinobu OHIRA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Nuclei of aged myofibres undergo structural and functional changes suggesting impairment in RNA processing

(2011) M Malatesta et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function

(2011) Sachiko Homma et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Immunodetection of Human Double Homeobox 4

(2011) Linda N. Geng et al.   HYBRIDOMA

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration

(2011) Tania F. Gendron et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene

(2010) Lauren Snider et al.   PLoS Genetics

Ku70 regulates Bax-mediated pathogenesis in laminin- 2-deficient human muscle cells and mouse models of congenital muscular dystrophy

(2009) V. K. Vishnudas et al.   HUMAN MOLECULAR GENETICS