Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Biochemistry & Molecular Biology
Yingjie Zhu, Chunyan Wang, Jingjing Luo, Shucheng Hua, Dan Li, Liping Peng, Hongmei Liu, Lei Song
Summary: Zingerone treatment alleviated oxidative stress and inflammation in asthma models by upregulating the AMPK/Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Maria Teresa Bayo Jimenez, Katie Frenis, Swenja Kroller-Schon, Marin Kuntic, Paul Stamm, Miroslava Kvandova, Matthias Oelze, Huige Li, Sebastian Steven, Thomas Munzel, Andreas Daiber
Summary: This study investigated the protective effects of HO-1 inducer and NRF2 activator on mice exposed to aircraft noise, showing that these treatments can mitigate the adverse effects of noise on vascular function by normalizing arterial hypertension and vascular dysfunction, as well as reducing oxidative stress and inflammation levels triggered by noise exposure. The study identifies new potential targets for mitigating the health effects of environmental noise exposure, suggesting that natural dietary constituents with HO-1 and NRF2 induction properties could be promising for preventive measures.
Article
Cell Biology
Eun-Nam Kim, Nguyen Minh Trang, Heesun Kang, Ki Hyun Kim, Gil-Saeng Jeong
Summary: This study demonstrates that phytol inhibits osteoclast differentiation through Nrf2 regulation, suggesting its potential use in oxidative stress-related osteoporosis and bone diseases.
Article
Biochemistry & Molecular Biology
Tao Xiao, Hongtao Qu, Zhiqing Zeng, Chuanghua Li, Juan Wan
Summary: This study revealed that exosomes derived from M2-polarized macrophages (M2-Exo) exert protective effects against ischemia-reperfusion injury in HT22 neurons, mediated by the activation of the Nrf2/HO-1 signaling pathway.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Medicine, Research & Experimental
Demiana H. Sami, Ayman S. Soliman, Akef A. Khowailed, Emad H. M. Hassanein, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: In this study, the protective effect of the antioxidant 7-hydroxycoumarin (7-HC) against cisplatin-induced acute kidney injury was investigated. Results showed that 7-HC prevented kidney dysfunction and tissue injury, suppressed oxidative stress and inflammation, and modulated several signaling pathways. Molecular docking revealed the potential binding of 7-HC to specific proteins involved in these pathways.
Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Cheol Park, Hee-Jae Cha, Da Hye Kim, Chan -Young Kwon, Shin-Hyung Park, Su Hyun Hong, EunJin Bang, Jaehun Cheong, Gi-Young Kim, Yung Hyun Choi
Summary: The study aimed to investigate the protective efficacy of fisetin on H2O2-induced oxidative damage in C2C12 murine myoblasts. The results showed that fisetin significantly weakened H2O2-induced cell viability inhibition, DNA damage, and ROS generation. Fisetin also alleviated cell cycle arrest and apoptosis induced by H2O2, while increasing the Bcl-2/Bax ratio and attenuating mitochondrial damage. Furthermore, fisetin-induced activation of Nrf2 and HO-1 was found to be important for its protective effects. However, inhibiting HO-1 activity greatly offset the protective efficacy of fisetin.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yang Huang, Zi Ye, Yujing Yin, Tianju Ma, Qi Zhang, Kun Shang, Wenqian Chen, Zhaohui Li
Summary: The loss of HO-1 enzymatic activity induces early-onset nuclear cataracts by activating oxidative stress and ER stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Rui Li, Xin Zeng, Meihua Yang, Xiaohui Xu, Jinmei Feng, Liming Bao, Bingqian Xue, Xin Wang, Yi Huang
Summary: The study found that DPP-4i may accelerate murine breast cancer metastasis by promoting an oncogenic ROS-NRF2-HO-1 axis, inducing aberrant oxidative stress through ROS overproduction. Therefore, this research not only reveals the oncogenic role of DPP-4i in breast cancer progression but also provides a new strategy to alleviate the adverse effects of DPP-4i by targeting HO-1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nashwa Amin, Xiaoxue Du, Shijia Chen, Qiannan Ren, Azhar B. Hussien, Benson O. A. Botchway, Zhiying Hu, Marong Fang
Summary: The study demonstrates that TQ can significantly reduce brain damage and motor dysfunction following ischemic stroke by decreasing cell death, inflammation, oxidative stress, apoptosis, and autophagy. The activation of the Nrf2/HO-1 signaling pathway by TQ plays a vital role in modulating these processes. TQ is also found to have minimal toxicity in liver tissue, suggesting its potential as a promising intervention therapy for cerebral ischemia.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Biochemistry & Molecular Biology
Eniko Balogh, Arpan Chowdhury, Haneen Ababneh, David Mate Csiki, Andrea Toth, Viktoria Jeney
Summary: Calcific aortic valve stenosis (CAVS) is characterized by fibro-calcific remodeling of the aortic valves, and activation of the Nrf2/HO-1 pathway inhibits VIC calcification. This study demonstrates that heme-induced Nrf2/HO-1 expression in VICs inhibits calcification, attributing this effect to the end products generated by HO-1-mediated heme degradation and ferritin.
Article
Cell Biology
Yuuki Yamaguchi, Hiroyuki Kanzaki, Yuta Katsumata, Kanako Itohiya, Sari Fukaya, Yutaka Miyamoto, Tsuyoshi Narimiya, Satoshi Wada, Yoshiki Nakamura
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Surgery
Yoshimichi Imai, Tetsu Nakajo, Kazuaki Nishimura, Hiroyuki Kanzaki, Takayoshi Daimaruya, Akimitsu Satoh, Kaoru Igarashi, Masahiro Tachi
JOURNAL OF CRANIOFACIAL SURGERY
(2018)
Article
Chemistry, Physical
Akira Kuroiwa, Yoshiaki Nomura, Tsuyoshi Ochiai, Tomomi Sudo, Rie Nomoto, Tohru Hayakawa, Hiroyuki Kanzaki, Yoshiki Nakamura, Nobuhiro Hanada
Letter
Dentistry, Oral Surgery & Medicine
Sari Fukaya, Hiroyuki Kanzaki, Yutaka Miyamoto, Yuki Yamaguchi, Yoshiki Nakamura
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2018)
Article
Endocrinology & Metabolism
Yuki Yamaguchi, Hiroyuki Kanzaki, Yutaka Miyamoto, Kanako Itohiya, Sari Fukaya, Yuuta Katsumata, Yoshiki Nakamura
Article
Polymer Science
Yuta Katsumata, Hiroyuki Kanzaki, Yoshitomo Honda, Tomonari Tanaka, Yuuki Yamaguchi, Kanako Itohiya, Sari Fukaya, Yutaka Miyamoto, Tsuyoshi Narimiya, Satoshi Wada, Yoshiki Nakamura
Article
Multidisciplinary Sciences
Hiroyuki Kanzaki, Satoshi Wada, Masao Kumazawa, Yuko Yamada, Tomomi Sudo, Erika Ozawa, Takuya Seko, Shun Akaike, Masumi Murakami, Takashi Oikawa, Satoshi Okumura, Yoshiki Nakamura, Hiroshi Tomonari
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Shigeki Kato, Yuko Shirai, Chihiro Motozono, Hiroyuki Kanzaki, Shiro Mori, Tetsuya Kodama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Takenobu Ishii, Montserrat Ruiz-Torruella, Jae Young Kim, Hiroyuki Kanzaki, Abdullah Albassam, Wichaya Wisitrasameewong, Satoru Shindo, Roodelyne Pierrelus, Alireza Heidari, Umadevi Kandalam, Shin Nakamura, Alexandru Movila, Dmitriy Minond, Toshihisa Kawai
Summary: Bone remodelling is regulated by communication between osteoclasts and osteoblasts, and Sema4D, produced by osteoclasts, plays a key role in downmodulating osteoblastogenesis. The mechanism responsible for producing soluble Sema4D from osteoclasts is unknown.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Yoshitomo Honda, Anqi Huan, Jianxin Zhao, Xiaoyu Han, Yuji Kurushima, Yanan Gong, Hiroyuki Kanzaki, Yuta Katsumata, Yoichi Yamada, Yoshiya Hashimoto, Naoyuki Matsumoto, Shunsuke Baba, Tomonari Tanaka, Makoto Umeda
JOURNAL OF HARD TISSUE BIOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Yutaka Miyamoto, Hiroyuki Kanzaki, Tsuyoshi Amemiya, Yoshiki Hamada, Yoshiki Nakamura
AUSTRALASIAN ORTHODONTIC JOURNAL
(2019)
Article
Endocrinology & Metabolism
Tsuyoshi Narimiya, Hiroyuki Kanzaki, Yuki Yamaguchi, Satoshi Wada, Yuta Katsumata, Ken Tanaka, Hiroshi Tomonari
Article
Cell Biology
Hiroyuki Kanzaki, Satoshi Wada, Yuuki Yamaguchi, Yuta Katsumata, Kanako Itohiya, Sari Fukaya, Yutaka Miyamoto, Tsuyoshi Narimiya, Koji Noda, Yoshiki Nakamura
BMC MOLECULAR AND CELL BIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Yutaka Miyamoto, Hiroyuki Kanzaki, Yoshiki Nakamura
INTERNATIONAL ORTHODONTICS
(2018)
Review
Dentistry, Oral Surgery & Medicine
Hiroyuki Kanzaki, Yoshiki Nakamura
JOURNAL OF ORAL BIOSCIENCES
(2018)