Review
Plant Sciences
Petr Dvorak, Yuliya Krasylenko, Adam Zeiner, Jozef Samaj, Tomas Takac
Summary: Reactive oxygen species (ROS) are essential signaling molecules in plant responses to environmental stimuli and development. Antioxidant enzymes play a critical role in scavenging ROS and their regulation is influenced by both environmental conditions and transcriptional activation.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Health Care Sciences & Services
Beom-Jun Ku, Kangeun Ko, Ki-Ok Shin, Ju-Yong Bae
Summary: This study found that a 12-week Taekwondo self-defense training course significantly improved side-step ability, reduced malondialdehyde levels, increased superoxide dismutase levels, and decreased tumor necrosis factor ff levels in postmenopausal women.
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Environmental Sciences
Tao-lin Qing, Lang Yan, Shao-kang Wang, Xiao-yu Dai, Li-jun Ren, Ji-qian-zhu Zhang, Wen-jing Shi, Xiao-fang Zhang, Mei-tang Wang, Ji-kuai Chen, Jiang-bo Zhu
Summary: The study found that multi-walled carbon nanotubes (MWCNTs) induce oxidative stress by overproducing reactive oxygen species (ROS), leading to cytotoxicity. However, celastrol, a plant-derived compound, has antioxidant effects by reducing ROS production. The results showed that MWCNT exposure decreased cell viability and increased ROS production. Knockdown of Nrf2 increased ROS production and cytotoxicity, while knockdown of Keap1 decreased ROS production and attenuated cytotoxicity. Treatment with celastrol significantly reduced ROS production and promoted Keap1 degradation, leading to increased Nrf2 translocation to the nucleus and increased HO-1 expression. In vivo results demonstrated that celastrol alleviated inflammatory damage in lung tissues, increased levels of antioxidants, GSH and SOD, and promoted HO-1 expression in MWCNT-treated mice. Therefore, celastrol can alleviate MWCNT-induced oxidative stress through the Keap1/Nrf2/HO-1 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Swati Sachdev, Shamim Akhtar Ansari, Mohammad Israil Ansari, Masayuki Fujita, Mirza Hasanuzzaman
Summary: Climate change has devastating effects on plants, leading to the production of reactive oxygen species (ROS) as byproducts of oxygen consumption. While excessive ROS can disrupt cellular homeostasis, moderate levels can activate growth and stress responses in plants, though the exact mechanisms are not fully understood. Advancements in modern techniques like molecular priming and crop modeling offer potential solutions for managing ROS levels in plants under stress.
Article
Nutrition & Dietetics
Yuri Sawada, Hiroshi Ichikawa, Naoyuki Ebine, Yukiko Minamiyama, Ahad Abdulkarim D. Alharbi, Noriaki Iwamoto, Yoshiyuki Fukuoka
Summary: High-intensity exercise leads to an excess production of reactive oxygen species (ROS) in skeletal muscle, so athletes need to maintain higher ROS scavenging activity. We studied the changes in six different ROS scavenging activities in athletes after high-intensity anaerobic exercise. The results showed that some ROS scavenging activities increased immediately following the exercise, and the responsiveness of OH scavenging activity might be related to anaerobic exercise performance.
Article
Biochemistry & Molecular Biology
Xia Wu, Xueliang Zhou, Songqing Lai, Jichun Liu, Jianwei Qi
Summary: This study reveals the mechanism of diabetic cardiomyopathy and finds that high glucose leads to excessive ROS production, inhibiting the activation of the Nrf2 signaling pathway, resulting in decreased cardiac energy metabolism and increased cell apoptosis. Additionally, it is discovered that activation of the Nrf2 signaling pathway can reduce ROS formation, increase antioxidant enzyme activity, and inhibit cardiomyocyte apoptosis.
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Immunology
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Gross, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi
Summary: This study investigated the signaling cascade necessary for macrophage recruitment and activation after injury, using transparent zebrafish larvae as a model system. The findings suggest that inhibiting intracellular Ca-2+ release impairs macrophage recruitment and activation, while ROS is necessary for macrophage activation independently of calcium. Neutrophils were found not to be essential for macrophage recruitment and activation in this process. Additionally, Src family kinases Lyn and Yrk and NF-kappa B were identified as key regulators of macrophage activation in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Plant Sciences
Md. Sanaullah Biswas, Jun'ichi Mano
Summary: Oxidation of membrane lipids leads to the formation of bioactive compounds known as oxylipins, including a group of reactive carbonyl species (RCS) that play a crucial role in connecting ROS stimuli and cellular responses in plants. By controlling RCS-scavenging enzymes or adding RCS-scavenging chemicals, various plant responses to ROS can be suppressed.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Developmental Biology
R. Emily Martin, Eliana Marzol, Jose M. Estevez, Gloria K. Muday
Summary: Research shows that ethylene and its precursor regulate root hair formation by increasing ROS accumulation. Ethylene-sensitive mutants have increased root hair number and ROS accumulation, while ethylene-insensitive mutants show the opposite effect.
Article
Pharmacology & Pharmacy
Bin Pan, Lin Zheng, Jiawei Fang, Ye Lin, Hehuan Lai, Jiawei Gao, Wenzheng Pan, Yejin Zhang, Kainan Ni, Chao Lou, Dengwei He
Summary: Azilsartan inhibits osteoclastogenesis by reducing ROS production and may serve as a novel treatment strategy for osteoporosis caused by osteoclast overactivation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Chan Liu, Weibiao Liao
Summary: Potassium ion is an essential signaling molecule in plant growth and development. It interacts with calcium, reactive oxygen species, and reactive nitrogen species to regulate plant growth, development, and abiotic stress responses.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Immunology
Xiaoning Wei, Qiaoqiao Huang, Jinbing Huang, Li Yu, Junying Chen
Summary: Our research aims to assess the influence of erastin, a ferroptosis-inducing agent, on cervical cancer cells.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Aaron J. Done, Tinna Traustadottir
Article
Biochemistry & Molecular Biology
Aaron J. Done, Matthew J. Gage, Nathan C. Nieto, Tinna Traustadottir
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Aaron J. Done, Michael J. Newell, Tinna Traustadottir
FREE RADICAL RESEARCH
(2017)
Article
Geriatrics & Gerontology
Trevor C. Nordin, Aaron J. Done, Tinna Traustadottir
Article
Surgery
Aaron J. Done, Marshall J. Fairres, Joseph C. Heiler, Cody J. Smith, William Rappaport
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Otorhinolaryngology
John P. Richards, Aaron J. Done, Samuel R. Barber, Saurabh Jain, Young-Jun Son, Eugene H. Chang
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2020)