Article
Biochemistry & Molecular Biology
Catia Sousa, Bruno Miguel Neves, Alcino Jorge Leitao, Alexandrina Ferreira Mendes
Summary: The study revealed that (S)-(+)-carvone can inhibit inflammation by modulating SIRT1 activity and NF-kappa B/p65 acetylation, suggesting its potential as an anti-inflammatory agent.
Article
Food Science & Technology
Mengqi Li, Qi Ge, Hanting Du, Songyi Lin
Summary: The study demonstrates that Tricholoma matsutake peptides can protect against LPS-induced inflammation by inhibiting the production of inflammatory cytokines and NF-kappa B activation, reducing cellular damage and preserving mitochondrial function.
Article
Microbiology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Shin-ichi Miyoshi, Kei Kitahara, Prolay Halder, Hemanta Koley, Mamta Chawla-Sarkar
Summary: This study evaluated the potential of quercetin as an anti-rotavirus therapeutic. Both in vitro and in vivo studies demonstrated that quercetin can effectively inhibit rotavirus replication and infection, and its antiviral activity is independent of interferon. This study provides important evidence for the future use of quercetin as a treatment for rotaviral diarrhea.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chongshan Dai, Qinzhi Zhang, Linjie Shen, Gaurav Sharma, Haiyang Jiang, Zhanhui Wang, Jianzhong Shen
Summary: This study reveals that quercetin can protect human cells from damage caused by quinocetone (QCT) through activating the p38/Nrf2/HO-1 pathway and inhibiting the ROS/mitochondrial apoptotic pathway.
Review
Pharmacology & Pharmacy
Arun Reddy Ravula, Suraj Benerji Teegala, Shanker Kalakotla, Jagadeesh Prasad Pasangulapati, Venkatesan Perumal, Hemanth Kumar Boyina
Summary: Fisetin, as a potential molecule for treating neurodegenerative diseases, is believed to positively impact neurobehavioral and cognitive abnormalities. It has shown various health benefits in clinical models of neurodegenerative diseases and is thought to have the potential to treat these diseases through multiple mechanisms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Jin Ha Park, Jiae Lee, Gong-Rak Lee, Minjeong Kwon, Hye In Lee, Narae Kim, Hee Jin Kim, Mi-Ock Lee, Woojin Jeong
Summary: Cholesterol sulfate (CS) activates retinoic acid-related orphan receptor a (ROR alpha). CS and ROR alpha inhibit osteoclast differentiation. The mechanism involves the AMPK-Sirt1 axis, leading to NF-kappa B inhibition. CS also induces apoptosis and protects against bone loss in mouse models.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bingjia Zhao, Qian Zhang, Xiaochun Liang, Jun Xie, Qing Sun
Summary: The study demonstrated that quercetin improved symptoms of diabetic peripheral neuropathy (DPN) in rats, such as mechanical withdrawal threshold, nerve conduction velocity, and pathological changes. Quercetin also exhibited anti-inflammatory effects, possibly mediated through the TLR4/MyD88/NF-kappa B signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Saverio Marchi, Emma Guilbaud, Stephen W. G. Tait, Takahiro Yamazaki, Lorenzo Galluzzi
Summary: This article discusses the molecular mechanisms by which mitochondrial dysfunction leads to inflammatory reactions, the cellular pathways that regulate them, and the pathological consequences of dysregulated inflammatory responses elicited by mitochondrial damage-associated molecular patterns (DAMPs).
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Oncology
Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang, Dengke Bao
Summary: The study demonstrated that ivermectin significantly inhibits the proliferation of ESCC cells and induces apoptosis. Mechanistically, ivermectin induces mitochondrial dysfunction and apoptosis pathway, leading to apoptosis of ESCC cells.
Article
Neurosciences
Taotao Lu, Linlin Ding, Xiaoqing Zheng, Yongxu Li, Wei Wei, Weilin Liu, Jing Tao, Xiehua Xue
Summary: Chronic consumption of a high-fat diet leads to brain aging characterized by cognitive decline, inflammatory responses, and neurovascular damage. Alisol A (AA) has potential therapeutic effects for metabolic diseases, and this study investigates whether it can protect against HFD-induced brain aging. Results showed that AA treatment improves cognitive function, reduces inflammation, and promotes the survival of neurons in the hippocampus. Mechanistically, AA targets the SIRT3-NF-?B/MAPK pathway and prevents tight junction degeneration in endothelial cells and apoptosis in hippocampal neurons. These findings suggest that AA may be a promising agent for the treatment of brain aging caused by a high-fat diet.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Pharmacology & Pharmacy
Tianrun Liu, Yingyu Li, Lumeng Wang, Xiaomeng Zhang, Yuxuan Zhang, Xuejie Gai, Li Chen, Lei Liu, Limin Yang, Baixin Wang
Summary: This study investigated the effects of mulberry leaf on enterovirus 71 (EV71) using network pharmacology, molecular docking, and in vitro experiments. The results revealed that quercetin, a major ingredient in mulberry leaf, exhibits potent anti-EV71 properties by inhibiting the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Physiology
Yi Cai, Shan Shan Yu, Yang He, Xue Ying Bi, Si Gao, Ting Dong Yan, Guo Dong Zheng, Ting Ting Chen, Jian Tao Ye, Pei Qing Liu
Summary: EGCG from green tea inhibits cardiac hypertrophy by regulating the PSMB5/Nmnat2/SIRT6 signaling pathway and blocking NF-kappa B DNA binding activity.This highlights the therapeutic potential of EGCG in the prevention and treatment of cardiac hypertrophy.
Article
Orthopedics
Z. Shao, B. Wang, Y. Shi, C. Xie, C. Huang, B. Chen, H. Zhang, G. Zeng, H. Liang, Y. Wu, Y. Zhou, N. Tian, A. Wu, W. Gao, X. Wang, X. Zhang
Summary: In vitro, QUE inhibits SASP factors expression and senescence phenotype in IL-10-treated NPCs. QUE suppresses IL-1 beta induced activation of the NF-kappa B pathway cascades. In vivo, QUE ameliorates the IDD process in the puncture-induced rat model.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Biochemistry & Molecular Biology
Ming-Chang Chiang, Tsung-Yu Tsai, Chieh-Ju Wang
Summary: Neuroinflammation is a critical factor in the development and progression of various brain diseases. Understanding its mechanisms and developing strategies to control it is crucial for treating brain disorders. Quercetin, a flavonoid found in many fruits and vegetables, has shown anti-inflammatory and neuroprotective properties and holds promise as a therapy for neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Nicolas Jeria, Sebastian Cornejo, Gabriel Prado, Andres Bustamante, Diego F. Garcia-Diaz, Paula Jimenez, Rodrigo Valenzuela, Carlos Poblete-Aro, Francisca Echeverria
Summary: The generation of agro-industrial by-products is a problem in terms of economics and the environment, but these materials can be a valuable source of bioactive compounds for various purposes. With the increasing prevalence of obesity and metabolic syndrome, there is a constant need for new strategies to prevent and treat these conditions. Revalorization of agro-industrial by-products for functional foods and nutraceutical development is gaining importance.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Clinical Neurology
Jochem Helleman, Barbara Johnson, Cory Holdom, Esther Hobson, Deirdre Murray, Frederik J. Steyn, Shyuan T. Ngo, Anjali Henders, Madhura B. Lokeshappa, Johanna M. A. Visser-Meily, Leonard H. van den Berg, Orla Hardiman, Anita Beelen, Chris McDermott, Ruben P. A. van Eijk
Summary: This study investigated the attitude and preferences of patients with motor neuron disease (MND) towards remote monitoring and the use of digital technology. The results showed that the majority of patients were positive about self-monitoring their health from home and being remotely monitored by a multidisciplinary care team. They were also willing to participate in clinical trials from home. However, some patients expressed concerns about the burden and distress of home-monitoring, as well as privacy and data security. Addressing these concerns is important for the widespread adoption of remote digital technology in clinical MND care.
JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leanne Jiang, Shyuan T. Ngo
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disorder with no cure available. TDP-43, a protein found in more than 97% of ALS patients, is believed to play a crucial role in the disease process. Targeting TDP-43 could be a promising approach for future therapeutic investigations.
Review
Biochemistry & Molecular Biology
Jaime Zapata, Mauricio Castro-Sepulveda, Sandra Soto-Alarcon, Daniela Alvarez, Andres Bustamante, Guiselle Villarroel, Arturo Gallardo, Diego Fernando Garcia-Diaz, Rodrigo Valenzuela, Francisca Echeverria
Summary: Nonalcoholic fatty liver disease (NAFLD) has a high and growing prevalence globally. Mitochondria play a crucial role in regulating cell energy homeostasis, but their control mechanisms can be disrupted in the context of energy overload. Damaged mitochondria worsen NAFLD progression. Diet and lifestyle changes are the main recommendations for NAFLD prevention and treatment. Some polyphenols have shown promising effects in improving mitochondrial function in NAFLD and obesity models.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Clinical Neurology
Gerald A. Dienel, Lisa Gillinder, Aileen McGonigal, Karin Borges
Summary: Seizures often originate in epileptogenic foci. Between seizures (interictally), the foci and surrounding tissue often have low signals in FDG-PET, indicating glucose hypometabolism. Normal glucose but high glycogen levels have been found in epileptogenic brain areas during the interictal period. Glycogenolysis may lead to low FDG signals and contribute to seizure generation.
Article
Clinical Neurology
Jeryn Chang, Thomas B. Shaw, Cory J. Holdom, Pamela A. McCombe, Robert D. Henderson, Jurgen Fripp, Markus Barth, Christine C. Guo, Shyuan T. Ngo, Frederik J. Steyn
Summary: This study found that lower hypothalamic volume is associated with lower and higher BMI in ALS patients, unlike AD patients and controls. Hypothalamic volume is not related to loss of appetite or hypermetabolism. In ALS patients, lower hypothalamic volume with lower BMI is associated with weight loss and earlier death.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jens Andersen, Emil W. Westi, Elliott S. Neal, Blanca Aldana, Karin Borges
Summary: Ketogenic diets and medium-chain triglycerides play important roles in the treatment of neurological disorders, with their metabolites serving as auxiliary brain fuels in different cell types without notable competition.
NEUROCHEMICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Elliott S. Neal, Vinod Kumar, Karin Borges, James S. M. Cuffe
Summary: Vitamin B-12 deficiency is common in individuals with diabetes mellitus, and it may contribute to impaired glucose homeostasis. In a study using rats, B-12 deficiency led to a prediabetic-like phenotype characterized by glucose intolerance and increased ketogenesis. The deficiency was associated with reduced liver anaplerosis, altered one-carbon metabolite levels, and decreased B vitamins in the liver, which likely contributed to deficits in glucose handling. These findings highlight the importance of adequate B-12 intake for metabolic health and suggest that B-12 deficiency may promote the development of metabolic disorders like diabetes mellitus.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Cory J. Holdom, Jordi W. J. van Unnik, Ruben P. A. van Eijk, Leonard H. van den Berg, Robert D. Henderson, Shyuan T. Ngo, Frederik J. Steyn
Summary: This study examined the use of wrist and hip accelerometers to measure activity levels in patients with Motor Neuron Disease (MND) compared to controls. The results showed that wrist-based measurements were more variable and had differing sensitivity to specific functional outcomes compared to hip-based measurements. Careful selection of measurement devices and analysis methods is necessary for at-home monitoring of disease progression in patients with MND.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Jeremy M. Shefner, Antonio Musaro, Shyuan T. Ngo, Christian Lunetta, Frederik J. Steyn, Richard Robitaille, Mamede De Carvalho, Seward Rutkove, Albert C. Ludolph, Luc Dupuis
Summary: Amyotrophic lateral sclerosis (ALS), a major motor neuron disease, has long been considered as primarily affecting motor neurons and neuromuscular junctions, with muscle changes being secondary. However, recent studies have shown that skeletal muscle dysfunction might contribute to muscle weakness, as well as the degeneration of neuromuscular junctions and motor neurons in ALS. This article explores the various potential roles of skeletal muscle in ALS pathophysiology and compares ALS to other motor neuron diseases, providing insights for future research and treatment.
Review
Biochemistry & Molecular Biology
Elliott S. Neal, Weizhi Xu, Karin Borges
Summary: Recent research has identified individual mutations in people with genetic epilepsies, leading to the development of genetic therapies. However, medication-resistant epilepsies still require alternative treatments, such as the ketogenic diet. The metabolic basis of ion channel epilepsies and their response to dietary therapies need further investigation.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Clinical Neurology
Albert Ludolph, Luc Dupuis, Edward Kasarskis, Frederik Steyn, Shyuan Ngo, Christopher McDermott
Summary: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with non-motor symptoms. Nutritional status and metabolic balance have been found to contribute to faster disease progression and earlier death. Cellular changes, including mitochondrial dysfunction, are also shown to contribute to bioenergetic failure in ALS. Modifying energy balance in ALS shows potential as a treatment option and multiple clinical trials are underway.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Cell & Tissue Engineering
Timothy J. Tracey, Leanne Jiang, Melinder K. Gill, Samara N. Ranie, Dmitry A. Ovchinnikov, Ernst J. Wolvetang, Shyuan T. Ngo
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, and the TDP-43 protein plays a crucial role in its pathophysiology. This study used the CRISPR-Cas9 system to introduce a heterozygous missense mutation (c.1144G > A, p.A382T) in exon 6 of the TARDBP gene into iPSCs derived from a healthy individual. The edited iPSCs maintained normal cellular morphology, pluripotency markers expression, tri-lineage differentiation ability, and karyotype.
STEM CELL RESEARCH
(2023)
Article
Nutrition & Dietetics
Cynthia Barrera, Valeska Castillo, Rodrigo Valenzuela, Carina A. Valenzuela, Diego F. Garcia-Diaz, Miguel Llanos
Summary: This study aimed to determine the effects of a nutritional intervention during pregnancy and lactation on metabolic alterations of obese female progenitors' offspring and on the involvement of the endocannabinoid system (ECS). The results showed that the intervention normalized some hormonal parameters and hepatic mRNA levels of ECS components, improving the condition of the obese offspring.
Article
Food Science & Technology
Catalina Carrasco-Pozo, Vicky M. Avery
Summary: The study aimed to investigate the role of dietary components and their microbiota-derived metabolites in the initiation of lung cancer. Natural compounds and metabolites, such as sulforaphane, apigenin, quercetin, and gallic acid, were found to reduce cell viability and glycolysis in early-stage lung cancer cells. Moreover, sulforaphane and quercetin metabolite, 3,4-dihydroxyphenylacetic acid, completely prevented the increase in glycolysis induced by hemin and PhIP in early-stage lung cancer cells.
ACS FOOD SCIENCE & TECHNOLOGY
(2023)