Article
Biochemistry & Molecular Biology
Priyanka N. Bushana, Michelle A. Schmidt, Kevin M. Chang, Trisha Vuong, Barbara A. Sorg, Jonathan P. Wisor
Summary: Non-rapid eye movement sleep (NREMS) is associated with decreased cerebral metabolism, decreased oxidative stress, and the importance of timing antioxidant administration relative to sleep/wake cycles in brain disorders.
Article
Biochemistry & Molecular Biology
Ahmed Fareed Alkandari, Sampath Madhyastha, Muddanna S. Rao
Summary: Oxidative stress and depletion of glutathione play a crucial role in the onset and progression of Alzheimer's disease. N-Acetylcysteine amide (NACA), a form of glutathione precursor, has extended bioavailability and shows neuroprotective effects in AD animal models. This study investigates the potential neuroprotective effects of NACA against AD-like pathology induced by Aβ1-42 peptide in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Qian Zhang, Wenkai Liu, Qian Li, Yitong Zeng, Mengjun Wu, Tao Wu, Shuangshuang Guo, Lei Wang, Di Zhao, Dan Yi, Yongqing Hou, Yong Liang
Summary: This study aimed to investigate the effect of N-acetylcysteine (NAC) on indomethacin (IDMT)-induced intestinal injury in a piglet model and explore the underlying molecular mechanisms. The results showed that NAC administration significantly increased the average daily gain of piglets, attenuated the intestine hyperemia, and restored normal jejunal morphology. NAC administration ameliorated intestinal injury in IDMT-challenged piglets by enhancing antioxidant and anti-inflammatory functions and modulating arginine metabolism in the small intestine.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Jagjeet Singh, Annu Phogat, Chandra Prakash, Sunil Kumar Chhikara, Sandeep Singh, Vinay Malik, Vijay Kumar
Summary: This study evaluated the effect of N-acetylcysteine (NAC) against monocrotophos (MCP) exposure-induced toxicity in the rat liver and found that NAC had hepatoprotective and antioxidant effects. Exposure to MCP caused liver tissue structural changes, oxidative stress, and inflammation, while pretreatment with NAC improved these adverse effects.
Article
Biochemistry & Molecular Biology
Amit Banik, Juneyong Eum, Byung Joon Hwang, Yun Kee
Summary: This study comprehensively explores the neurotoxic implications of dithianon on humans and wildlife using zebrafish larvae as a model. The research finds that dithianon induces behavioral alterations and disrupts cellular and mitochondrial homeostasis. It also regulates the expression levels of different neuronal markers in a concentration-dependent manner.
Article
Biochemistry & Molecular Biology
Twinkle Dhillon, Amit Kumar, Vijay Kumar
Summary: This study demonstrates that N-acetylcysteine offers neuroprotection by improving antioxidant response and decreasing oxidative stress in different regions of the rat brain. This is important for understanding and treating the neurotoxicity caused by monocrotophos.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Veterinary Sciences
Mohamed Aboubakr, Ahmed Mohamed Elmahdy, Shaimaa Taima, Mahmoud Abdelghaffar Emam, Ahmed Farag, Mohamed Alkafafy, Alshaimaa Mohamed Said, Ahmed Soliman
Summary: The aim was to investigate the protective effects of N-acetylcysteine (NAC) and/or vitamin E (Vit E) against acrylamide (ACR)-induced neurotoxicity. Rats were classified into different groups and treated with either NAC or Vit E alone or in combination with ACR. ACR ingestion resulted in various effects, including inhibition of acetylcholinesterase (AChE), depletion of glutathione, increased malondialdehyde (MDA) levels, and decreased activities of superoxide dismutase (SOD) and catalase (CAT). NAC or Vit E supplementation significantly reduced these adverse effects.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Lila Gonzalez-Hodar, Jeffrey G. McDonald, Goncalo Vale, Bonne M. Thompson, Ana-Maria Figueroa, Pablo J. Tapia, Fermin Robledo, Anil K. Agarwal, Abhimanyu Garg, Jay D. Horton, Victor Cortes
Summary: The adipocytes from Agpat2(-/-) mice have impaired adipogenesis and fewer caveolae, but insulin signaling remains conserved. Lipid composition changes during adipogenesis in wild type adipocytes while levels of main phospholipids decrease in both genotypes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Andrology
Victor Emojevwe, Eze Kingsley Nwangwa, Alexander Obidike Naiho, Mega Obukohwo Oyovwi, Osarugue Igiehon, Eunice Ogunwole, Margaret Sope Makinde-Taylor, Oluwadamilola Ayodele Ayotomide, Adeniran Oluwadamilare Akinola, Prince Tesi Edesiri, Bright Onome Oghenetega, Simon Irikefe Ovuakporaye
Summary: This study investigated the therapeutic efficacy of N-acetylcysteine (NAC) and zinc sulphate on DEHP-induced testicular oxido-nitrergic stress. The results showed that coadministration of NAC and zinc sulphate effectively improved testicular antioxidant status, reduced testicular nitregic stress, and improved testicular architecture and functions.
Article
Medicine, General & Internal
Hye-Jeong Hwang, Yu Jin Hwang, Young Jun Kim, Mina Kim, Kyung-A Hwang
Summary: The extract from sword bean pods has anti-obesity effects by inhibiting lipogenesis-related factors and activating fat-catabolizing factors.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Petr Mlejnek
Summary: In laboratory experiments, many cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or depletion of glutathione (GSH). N-acetylcysteine (NAC), used as a ROS scavenger and precursor of GSH biosynthesis, can inhibit ROS production, restore GSH levels, and prevent cell death. However, NAC has limitations in interacting with important ROS and is used at unnecessarily high concentrations. The possibility of NAC directly interacting with cytotoxic electrophiles to form non-cytotoxic adducts is often overlooked, despite being a common protective mechanism.
Review
Pharmacology & Pharmacy
Brandan Pedre, Uladzimir Barayeu, Daria Ezerina, Tobias P. Dick
Summary: Originally used as a mucolytic, N-acetylcysteine (NAC) is now a standard treatment for paracetamol poisoning and a widely used antioxidant. In addition to its traditional mechanisms, a newly discovered mechanism involves the conversion of NAC into hydrogen sulfide and sulfane sulfur species, which may explain many of its effects.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Veterinary Sciences
Tsvetelina Petkova, Aneliya Milanova
Summary: The study characterized the population pharmacokinetics of orally administered N-acetylcysteine (NAC) in broilers, showing that NAC was absorbed in all experimental chickens and reached maximum plasma concentrations in healthy chickens at 2.47±0.45 hours after dosing. The population pharmacokinetic analysis indicated no need for dose adjustment of NAC in M. gallisepticum-infected broilers or when combined with doxycycline.
VETERINARY SCIENCES
(2021)
Review
Nutrition & Dietetics
Emilia Vassilopoulou, George Guibas, Nikolaos G. Papadopoulos
Summary: The second wave of the allergy epidemic is currently affecting both affluent societies and developing countries. Changes in lifestyle and diet, including the consumption of processed foods, may contribute to the increase in prevalence of atopy/asthma. The Mediterranean diet has been studied as a potential protective factor against asthma/atopy, but the evidence is inconclusive.
Article
Food Science & Technology
Erica da Costa Moncao, Cristiani Viegas Brandao Grisi, Janaina de Moura Fernandes, Priscila Santos Souza, Antonia Lucia de Souza
Summary: Consumer demand for natural products with low concentration of additives and controlled environmental impact has posed a major challenge for the lipid food packaging industry. Active packaging trends such as oxygen absorbers and antioxidant releasers are gaining popularity in the industry. However, challenges related to the physical and mechanical properties of materials need to be addressed for the commercialization of oxygen absorbing and antioxidant-releasing packaging.
Article
Cell Biology
Emmanuel Lujan, Liliana N. Guerra, Alejandro Soba, Nicolas Visacovsky, Daniel Gandia, Juan C. Calvo, Cecilia Suarez
INTEGRATIVE BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Daniela Soto, Maria Gomez-Serrano, Azul Pieralisi, Juan C. Calvo, Belen Peral, Liliana N. Guerra
Article
Cell Biology
Emmanuel Lujan, Daniela Soto, Maria S. Rosito, Alejandro Soba, Liliana N. Guerra, Juan C. Calvo, Guillermo Marshall, Cecilia Suarez
INTEGRATIVE BIOLOGY
(2018)
Article
Oncology
L. N. Guerra, C. Suarez, D. Soto, A. Schiappacasse, D. Sapochnik, P. Sacca, G. Piwien-Pilipuk, B. Peral, J. C. Calvo
CLINICAL & TRANSLATIONAL ONCOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Pablo Calzadilla, Daiana Sapochnik, Soledad Cosentino, Virginia Diz, Lelia Dicelio, Juan Carlos Calvo, Liliana N. Guerra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
Eliana A. Miler, Maria del Carmen Rios de Molina, Gabriela Dominguez, Liliana N. Guerra
Article
Biochemistry & Molecular Biology
P. Calzadilla, M. Gomez-Serrano, E. Garcia-Santos, A. Schiappacasse, Y. Abalde, J. C. Calvo, B. Peral, L. N. Guerra
Article
Pharmacology & Pharmacy
Evelyn Frontera, Martin F. Desimone, Mauricio C. De Marzi, Liliana N. Guerra
Summary: The study aimed to increase the cellular uptake of NAC by encapsulating it in silica nanoparticles, but the coated nanoparticles showed a reduced effect on Tg cellular accumulation.
THERAPEUTIC DELIVERY
(2021)
Article
Biology
Vanina L. Julianelli, Liliana N. Guerra, Juan C. Calvo
Article
Medical Laboratory Technology
L. N. Guerra, E. A. Miler, S. Moiguer, M. Karner, A. M. Orlandi, H. Fideleff, J. A. Burdman
CLINICA CHIMICA ACTA
(2006)
Article
Medical Laboratory Technology
LN Guerra, MDCR de Molina, EA Miler, S Moiguer, M Karner, JA Burdman
CLINICA CHIMICA ACTA
(2005)
Article
Clinical Neurology
JA Burdman, LN Guerra, MT Calabrese, A Basso
NEUROLOGICAL RESEARCH
(2001)
Article
Biochemistry & Molecular Biology
LN Guerra, S Moiguer, M Karner, MDR de Molina, CM Sreider, JA Burdman
Correction
Medical Laboratory Technology
L. N. Guerra, E. A. Miler, S. Moiguer, M. Karner, A. M. Orlandi, H. Fideleff, J. A. Burdman
CLINICA CHIMICA ACTA
(2007)