Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

Favorable NK cell activity after haploidentical hematopoietic stem cell transplantation in stage IV relapsed Ewing’s sarcoma patients

(2015) P Schlegel et al.   BONE MARROW TRANSPLANTATION

Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

(2015) H. G. Caruso et al.   CANCER RESEARCH

Tumor Marker Usage and Medical Care Costs Among Older Early-Stage Breast Cancer Survivors

(2015) Scott D. Ramsey et al.   JOURNAL OF CLINICAL ONCOLOGY

DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy

(2015) Katrin Töpfer et al.   JOURNAL OF IMMUNOLOGY

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells

(2015) Jonathan P H Fisher et al.   OncoImmunology

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

(2014) E. K. Moon et al.   CLINICAL CANCER RESEARCH

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multimodality Imaging Methods for Assessing Retinoblastoma Orthotopic Xenograft Growth and Development

(2014) Timothy W. Corson et al.   PLoS One

Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice

(2014) Y. Chu et al.   Cancer Immunology Research

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

(2013) L. B. John et al.   CLINICAL CANCER RESEARCH

CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

(2013) J Chu et al.   LEUKEMIA

Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation”

(2013) Andreas A Hombach et al.   MOLECULAR THERAPY

Cytokine activation induces human memory-like NK cells

(2012) R. Romee et al.   BLOOD

The ganglioside antigen GD2 is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting

(2012) S Kailayangiri et al.   BRITISH JOURNAL OF CANCER

Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor

(2012) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural killer cells can exert a graft-vs-tumor effect in haploidentical stem cell transplantation for pediatric solid tumors

(2012) Antonio Pérez-Martínez et al.   EXPERIMENTAL HEMATOLOGY

Surface Expression of HLA-G is Involved in Mediating Immunomodulatory Effects of Placenta-Derived Multipotent Cells (PDMCs) towards Natural Killer Lymphocytes

(2011) Ko-Jiunn Liu et al.   CELL TRANSPLANTATION

Cytotoxicity of Activated Natural Killer Cells against Pediatric Solid Tumors

(2010) D. Cho et al.   CLINICAL CANCER RESEARCH

A simple method for identifying bone marrow mesenchymal stromal cells with a high immunosuppressive potential

(2010) Roberta Rizzo et al.   CYTOTHERAPY

Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial

(2010) Ruth Ladenstein et al.   JOURNAL OF CLINICAL ONCOLOGY

A Human NK Cell Activation/Inhibition Threshold Allows Small Changes in the Target Cell Surface Phenotype To Dramatically Alter Susceptibility to NK Cells

(2010) T. D. Holmes et al.   JOURNAL OF IMMUNOLOGY

2B4 (CD244) Signaling by Recombinant Antigen-specific Chimeric Receptors Costimulates Natural Killer Cell Activation to Leukemia and Neuroblastoma Cells

(2009) B. Altvater et al.   CLINICAL CANCER RESEARCH

Molecular characterization of commonly used cell lines for bone tumor research: A trans-European EuroBoNet effort

(2009) Laura Ottaviano et al.   GENES CHROMOSOMES & CANCER

Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition

(2009) Dagmar Berghuis et al.   JOURNAL OF PATHOLOGY

Activation of HLA-G expression by 5-aza-2´- deoxycytidine in malignant hematopoetic cells isolated from leukemia patients

(2009) K. POLAKOVA et al.   NEOPLASMA

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

(2009) C. Carpenito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways

(2008) Dirk H.J. Verhoeven et al.   MOLECULAR IMMUNOLOGY

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE

Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas

(2008) A. Kruschinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA