Article
Medicine, Research & Experimental
Dayson Moreira, Sagus Sampath, Haejung Won, Seok Voon White, Yu-Lin Su, Marice Alcantara, Chongkai Wang, Peter Lee, Ellie Maghami, Erminia Massarelli, Marcin Kortylewski
Summary: The study suggests that targeted inhibition of STAT3 in tumor-associated myeloid cells enhances the efficacy of radiotherapy against HNSCC by promoting the recruitment of CD8(+) T cells and suppressing tumor growth.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Chunmei Hu, Jiangang Fan, Gang He, Chuan Dong, Shijie Zhou, Yun Zheng
Summary: This study aimed to investigate the expression and prognostic value of five microsomal signal peptidase complex subunit genes in head and neck squamous cell carcinoma. The results showed that only SEC11A expression was independently associated with poorer progression-free survival and disease-specific survival. SEC11A upregulation was found in all subtypes of cells in the tumor microenvironment and correlated with the infiltration of certain types of immune cells.
Article
Oncology
Chengzhi Xu, Yunbin Zhang, Yupeng Shen, Yong Shi, Ming Zhang, Liang Zhou
Summary: This study identified ENDOU as a biomarker with prognostic significance in HNSCC progression. Overexpression of ENDOU inhibited proliferation and migration of FaDu and Cal-27 cells, indicating its tumor-suppressing role in HNSCC progression. GSEA analysis revealed ENDOU downstream pathways such as DNA replication, mismatch repair, cell cycle, and IL-17 signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Li Guan, Dhanya K. Nambiar, Hongbin Cao, Vignesh Viswanathan, Shirley Kwok, Angela B. Hui, Yuan Hou, Rachel Hildebrand, Rie von Eyben, Brittany J. Holmes, Junfei Zhao, Christina S. Kong, Nathan Wamsley, Weiruo Zhang, Michael B. Major, Seung W. Seol, John B. Sunwoo, D. Neil Hayes, Maximilian Diehn, Quynh-Thu Le
Summary: Radiotherapy is a primary treatment for head and neck squamous cell carcinoma (HNSCC), but there is currently no reliable biomarker for predicting radioresistance. This study found that mutations in the NFE2L2 gene are associated with higher rates of locoregional failure in HNSCC patients treated with surgery and (chemo)radiotherapy. NFE2L2 mutations lead to radioresistance through Nrf2 activation, but this can be overcome by the glutaminase inhibitor CB-839.
Article
Immunology
Yourong Jiang, Siwei Zhang, Lu Tang, Rui Li, Jinglei Zhai, Suisui Luo, Yiman Peng, Xiaohang Chen, Lanlan Wei
Summary: This study constructed a single-cell atlas of macrophages from HPV-negative and HPV-positive HNSCC patients using single-cell RNA sequencing data. The results showed that macrophages in HPV-positive HNSCC exhibit stronger phagocytic ability, while TCR+ macrophages play a critical role in the HNSCC microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Pan Xu, Ran Zhao, Chen-Yang Zhang, Qian-Qian Zhang, Yong Wang, Jun Zhu, Wei-Wen Jiang
Summary: TACC1 variant 25 (TACC1v25) is downregulated in head and neck squamous cell carcinoma (HNSCC), inhibiting proliferation and promoting autophagy through the ERK and AKT/mTOR pathways, suggesting its potential as a tumor suppressor in HNSCC.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Weihui Zheng, Ying Zhu, Xiaolong Chen, Jianqiang Zhao
Summary: This study revealed that PMN-MDSCs were significantly increased in HNSCC patients, contributing to MDSC-mediated T cell immune suppression. CD73 expression in PMN-MDSCs plays a key role in this immunosuppressive activity.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Wenru Jiang, Kangyao Hu, Xiaofei Liu, Jili Gao, Liping Zhu
Summary: Head and neck squamous cell carcinoma (HNSC) is a common malignant tumor in the head and neck regions. Myeloid-derived suppressor cells (MDSCs) play a role in inhibiting the immune response against the tumor. Through analyzing single-cell RNA sequencing data, it was found that SPP1 (+) tumor-associated macrophages (TAMs) and MDSCs were the most abundant myeloid cells in the tumor microenvironment. The study also identified a set of six MDSC-related genes as a prognostic signature, which showed promise in predicting patients' prognosis outcomes. The interactions between MDSCs and other cells likely contribute to the immunosuppressive microenvironment and tumor angiogenesis. Targeting MDSCs may be a promising approach for the immunotherapy of HNSC.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Cell Biology
Zhang-Wei Hu, Yi-Hui Wen, Ren-Qiang Ma, Lin Chen, Xue-Lan Zeng, Wei-Ping Wen, Wei Sun
Summary: The study identified the ferroptosis driver SOCS1 and suppressor FTH1 as independent prognostic factors in head and neck squamous cell carcinoma, correlating with M1 and M2 macrophage infiltration. Targeting ferroptosis-immunomodulation may enhance immunotherapy efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Zhifeng Liu, Diekuo Zhang, Chao Liu, Guo Li, Huihong Chen, Hang Ling, Fengyu Zhang, Donghai Huang, Xingwei Wang, Yong Liu, Xin Zhang
Summary: By establishing a myeloid gene score (MGS) risk model, it can help predict the prognosis and immune infiltration status of patients with head and neck squamous cell carcinoma (HNSCC). MGS shows high accuracy in identifying patients with poor prognosis, aggressive clinical parameters, and response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lei Chen, Shu-Cheng Wan, Liang Mao, Cong-Fa Huang, Lin-Lin Bu, Zhi-Jun Sun
Summary: This study found that the expression of NLRP3 in tumor-associated macrophages (TAMs) is positively correlated with TAM density in head and neck squamous cell carcinoma (HNSCC). High expression of NLRP3 in TAMs is associated with worse overall survival in HNSCC patients. NLRP3 activation in TAMs may contribute to tumor progression and have prognostic significance in HNSCC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Oncology
Xiao Han, Ruxian Tian, Cai Wang, Yumei Li, Xicheng Song
Summary: This review systematically summarizes the regulatory mechanisms of circular RNA (CircRNA) in head and neck squamous cell carcinoma (HNSCC), and explores its functions in tumor growth, cell death, angiogenesis, invasion, and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Elham Safarzadeh, Ali Mohammadi, Behzad Mansoori, Pascal H. G. Duijf, Shahryar Hashemzadeh, Vahid Khaze, Tohid Kazemi, Afshin Derakhshani, Nicola Silvestris, Behzad Baradaran
Summary: The study found that the levels of HLA-DR(-)CD33(+) MDSCs in the blood of breast cancer patients are elevated, and these cells can strongly suppress T cell proliferation and enter the tumor microenvironment. Inhibiting the STAT3 signaling pathway and activating the TLR7/8 pathway can reduce the immunosuppressive effects of patient-derived MDSCs on T cells and decrease breast cancer cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Toshimitsu Ohashi, Kosuke Terazawa, Hirofumi Shibata, Norimitsu Inoue, Takenori Ogawa
Summary: This study compared and assessed the metabolic profiles of head and neck squamous cell carcinoma (HNSCC) and normal tissues, finding that HNSCC exhibits enhanced metabolic activity, providing more energy and structural components, which promote rapid tumor growth and progression.
Article
Oncology
Liang Mao, Yao Xiao, Qi-Chao Yang, Shao-Chen Yang, Lei-Lei Yang, Zhi-Jun Sun
Summary: This study found that CD155 and PD-L1 are highly co-expressed on MDSCs in HNSCC patients, and the combined blockade of TIGIT/CD155 and PD-1/PD-L1 signaling significantly inhibited tumor growth in mouse models, enhanced the percentage of effector T cells, and induced immune memory effects.
Article
Dentistry, Oral Surgery & Medicine
Yu-Yue Zhao, Jun-Xiang Lian, Zhou Lan, Ke-Long Zou, Wei-Ming Wang, Guang-Tao Yu
Summary: This study found that ferroptosis can reverse the immunosuppressive tumor microenvironment and promote anti-tumor immune response. High expression of GPX4 was associated with poor survival, while the expression of GPX4 was negatively correlated with calreticulin, a protein related to immunogenic cell death.
Article
Chemistry, Physical
Jun-Jie Zhou, Xiao-Hong Li, Peng-Yu He, Fu-Yu Qi, Muhammad Wajid Ullah, Shu-Jin Li, Yuan-Tong Liu, Lin-Lin Bu, Guang Yang, Zhi-Jun Sun
Summary: A newly developed multifunctional nanocomposite combining photothermal therapy and immune checkpoint blockade shows potential for controlling local recurrence of HNSCC.
Article
Materials Science, Multidisciplinary
Hao Cui, Yan You, Guo-Wang Cheng, Zhou Lan, Ke-Long Zou, Qiu-Ying Mai, Yan-Hua Han, Hao Chen, Yu-Yue Zhao, Guang-Tao Yu
Summary: Oral diseases, with their high morbidity, have caused significant physical and mental damage to people worldwide. They have become an urgent global health problem due to the increasing burden on individuals and society. The rapid advancement of advanced materials and technologies has also revolutionized the treatment methods and strategies for oral diseases. This review provides a systematic summary of the application strategies in advanced materials and technologies, based on the etiology of the diseases and a comparison of old and new materials, as well as the challenges and future directions for their development in oral disease treatment. It will serve as a guide for both fundamental research and clinical translation in oral medicine.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Biao Huang, Tao Tang, Shi-Hui Chen, Hao Li, Zhi-Jun Sun, Zhi-Lin Zhang, Mingxi Zhang, Ran Cui
Summary: The authors designed a near-infrared-IIb emitting Mn single-atom catalyst for imaging-guided therapy to alleviate ROS-mediated neuroinflammation and obtain feedback of therapeutic effect in mice with traumatic brain injury. The catalyst promoted the reconstruction of blood-brain barrier and recovery of neurological function.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Shu-Cheng Wan, Meng-Jie Ye, Qi-Chao Yang, Tian Zhang, Meng-Jie Zhang, Xian-Bin Ma, Ji-Ming Xu, Shuo Wang, Zhi-Zhong Wu, Lei-Lei Yang, Xue-Meng Shen, Zhigang Xu, Zhi-Jun Sun
Summary: Pyroptosis triggers antitumor immunity and this study introduces a dual-responsive diselenide-based pyroptosis inducer that has excellent tumor microenvironment targeting effects. It can remodel the immunostimulated tumor microenvironment and trigger a robust immune response. Combined with αPD-1 therapy, it effectively inhibits the growth of remote tumors and prolongs survival.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Liang Mao, Jun-Jie Zhou, Yao Xiao, Qi-Chao Yang, Shao-Chen Yang, Shuo Wang, Zhi-Zhong Wu, Hong-Gang Xiong, Hai-Jun Yu, Zhi-Jun Sun
Summary: Combining immunogenic radiotherapy with anti-PD-L1 treatment can enhance the immune response in immunotherapy-resistant HNSCC mouse models.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Boxin Zhang, Hao Li, Yuan-Tong Liu, Dian Xiong, Lu Zhang, Zhi-Jun Sun
Summary: This study investigated the spatial architecture of immune cells in tertiary lymphoid structures (TLSs) associated with head and neck squamous cell carcinoma (HNSC). It identified chemokine receptors associated with TLSs and portrayed the cellular atlas using multiplex immunohistochemistry. The study also explored the functions and evolutionary trajectory of cells in TLSs, and proposed a method to enhance the antitumor immune response by inducing neogenesis TLSs in HNSC.
Article
Oncology
Yuan -Yuan Wang, Zhi-Zhong Wu, Cong-Fa Huang, Zhi-Jun Sun
Summary: Immunotherapy, particularly immune checkpoint blockade (ICB), has shown promise in cancer treatment but its efficacy is limited. This study focuses on understanding the alterations in the systemic immune system and immune macroenvironment and explores the role of the spleen, especially erythroid progenitor cells (EPCs), in tumor progression and immunotherapy. The findings suggest the potential for further research on EPCs and their mechanisms in tumor treatment.
Article
Immunology
Jie Liu, Wen -Ping Lin, Wen Su, Zhi-Zhong Wu, Qi-Chao Yang, Shuo Wang, Ting-Guan Sun, Cong-Fa Huang, Xiao-Long Wang, Zhi-Jun Sun
Summary: Combining EZH2 inhibitor and MDSC inhibitor can improve the response rate to immune-checkpoint-blocking therapy and reverse HNSCC-specific immunotherapeutic resistance, making it a promising strategy for overcoming resistance to ICB therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Li, S. -W. Zhu, J. -J. Zhou, D. -R Chen, J. Liu, Z. -Z Wu, W. -Y Wang, M. -J Zhang, Z. -J Sun
Summary: Immune checkpoint blockade therapy targeting PD-1/PD-L1 shows limited efficacy in head and neck squamous cell carcinoma (HNSCC), however, recent findings suggest that the presence of tertiary lymphoid structures (TLSs) in tumor tissue is associated with better prognosis and response to therapy. This study analyzed TCGA-HNSCC data and identified an immune classification for the tumor microenvironment (TME) of HNSCC and found that TLS enrichment was correlated with improved prognosis and response to immune checkpoint blockade treatment. Further experiments demonstrated that inducing TLS formation enhanced the response to PD-1 blockade treatment in HPV- HNSCC mouse models by increasing the presence of specific immune cells in the TME. The results suggest that inducing TLS formation could be a potential therapeutic approach for improving the response rate to immune checkpoint blockade therapy in HPV- HNSCC patients.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Oncology
Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang
Summary: Oncolytic viruses encoding various transgenes have been used to reverse the immunosuppressive tumor microenvironment, but the antiviral restriction factors that limit viral replication have been overlooked. In this study, researchers found that expressing a bacterial E3 ubiquitin ligase can effectively counteract a restriction factor and improve viral replication and therapeutic efficacy.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Review
Pharmacology & Pharmacy
Qiuying Mai, Yanhua Han, Guopan Cheng, Rui Ma, Zhao Yan, Xiaojia Chen, Guangtao Yu, Tongkai Chen, Shu Zhang
Summary: Around 50% of men and 15-30% of women suffer from hair-related problems, causing significant psychological burden. Traditional treatments, such as drug therapy and transplantation, face challenges like adverse effects and poor drug penetration. Therefore, efforts have been made to enhance drug permeation for hair regrowth. This review focuses on transdermal strategies involving external stimulation, regeneration, and microneedles, as well as natural products as alternative agents. It also discusses skin visualization strategies and provides information on relevant patents and clinical trials.
Article
Multidisciplinary Sciences
Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, An Song, Zhi-Zhong Wu, Shu-Cheng Wan, Hui-Min Li, Zhi-Jun Sun
Summary: PCSK9 expression is upregulated in HNSCC tissues and higher expression is associated with poorer prognosis. Inhibition of PCSK9 suppresses cancer cell stemness via LDLR-dependent mechanism. PCSK9 inhibition enhances CD8(+) T cell infiltration, reduces MDSCs, and improves the efficacy of anti-PD-1 ICB therapy in HNSCC.
Article
Otorhinolaryngology
Meng-Jie Zhang, Jie Liu, Shu-Cheng Wan, Jia-Xing Li, Shuo Wang, Nyimi Bushabu Fidele, Cong-Fa Huang, Zhi-Jun Sun
Summary: The study reveals that CSRP2 plays a crucial role in head and neck squamous cell carcinoma (HNSCC), and its overexpression is associated with poor prognosis. CSRP2 is involved in the regulation of cancer stemness and epithelial-to-mesenchymal transition (EMT) in HNSCC. This research provides a potential therapeutic target for the treatment of HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Zhou Lan, Ke-Long Zou, Hao Cui, Yu-Yue Zhao, Guang-Tao Yu
Summary: Porphyromonas gingivalis, an oral bacteria, can suppress the growth of oral squamous cell carcinoma by inducing cell cycle arrest, suppressing mucin and chemokine expression, and reversing the immunosuppressive tumor microenvironment.
MOLECULAR ONCOLOGY
(2023)