Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Therapy-induced tumour secretomes promote resistance and tumour progression

(2015) Anna C. Obenauf et al.   NATURE

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

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Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

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Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

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Lysosome: regulator of lipid degradation pathways

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Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

(2014) Youhua Tan et al.   Nature Communications

Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells via cGAS/STING Signaling

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Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

(2014) Damya Laoui et al.   Frontiers in Immunology

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

(2013) Giovanni Germano et al.   CANCER CELL

Macrophage Regulation of Tumor Responses to Anticancer Therapies

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Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

(2013) Numana Bhat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

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Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2

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Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

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Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

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Macrophage plasticity and polarization: in vivo veritas

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Macrophage plasticity and polarization in tissue repair and remodelling

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Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b

(2012) Dapeng Li et al.   OncoImmunology

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature

(2011) Zhenyu Qin   ATHEROSCLEROSIS

Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction

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Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells

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Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

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Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response

(2011) Siew-Min Ong et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microvesicles: Intercellular Vectors of Biological Messages

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Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Combating apoptosis and multidrug resistant cancers by targeting lysosomes

(2010) Line Groth-Pedersen et al.   CANCER LETTERS

Microparticles

(2010) Sebastian F. Mause et al.   CIRCULATION RESEARCH

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

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“Re-educating” tumor-associated macrophages by targeting NF-κB

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Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics

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TLR signaling by tumor and immune cells: a double-edged sword

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