4.7 Review

Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data

期刊

GIGASCIENCE
卷 5, 期 -, 页码 -

出版社

OXFORD UNIV PRESS
DOI: 10.1186/s13742-016-0117-6

关键词

Big data; Analytics; Modeling; Information technology; Cloud services; Processing; Visualization; Workflows

资金

  1. National Science Foundation [1416953, 0716055, 1023115]
  2. National Institutes of Health [P20 NR015331, U54 EB020406, P50 NS091856, P30 DK089503]
  3. Direct For Education and Human Resources
  4. Division Of Undergraduate Education [1416953, 1023115] Funding Source: National Science Foundation
  5. Division Of Undergraduate Education
  6. Direct For Education and Human Resources [0716055] Funding Source: National Science Foundation

向作者/读者索取更多资源

Managing, processing and understanding big healthcare data is challenging, costly and demanding. Without a robust fundamental theory for representation, analysis and inference, a roadmap for uniform handling and analyzing of such complex data remains elusive. In this article, we outline various big data challenges, opportunities, modeling methods and software techniques for blending complex healthcare data, advanced analytic tools, and distributed scientific computing. Using imaging, genetic and healthcare data we provide examples of processing heterogeneous datasets using distributed cloud services, automated and semi-automated classification techniques, and open-science protocols. Despite substantial advances, new innovative technologies need to be developed that enhance, scale and optimize the management and processing of large, complex and heterogeneous data. Stakeholder investments in data acquisition, research and development, computational infrastructure and education will be critical to realize the huge potential of big data, to reap the expected information benefits and to build lasting knowledge assets. Multi-faceted proprietary, open-source, and community developments will be essential to enable broad, reliable, sustainable and efficient data-driven discovery and analytics. Big data will affect every sector of the economy and their hallmark will be 'team science'.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Mathematical & Computational Biology

Optimal dynamic treatment regime estimation using information extraction from unstructured clinical text

Nina Zhou, Robert D. Brook, Ivo D. Dinov, Lu Wang

Summary: The wide-scale adoption of electronic health records provides extensive information for precision medicine and personalized healthcare. By leveraging free-text clinical information extraction techniques, optimal dynamic treatment regimes can be estimated, allowing for individualized treatments based on patient characteristics and treatment history.

BIOMETRICAL JOURNAL (2022)

Article Computer Science, Artificial Intelligence

Kimesurface representation and tensor linear modeling of longitudinal data

Rongqian Zhang, Yupeng Zhang, Yuyao Liu, Yunjie Guo, Yueyang Shen, Daxuan Deng, Yongkai Joshua Qiu, Ivo D. Dinov

Summary: This paper introduces a new method for representing, modeling, and analyzing repeated-measurement longitudinal data using tensor-based linear modeling and complex time transformations, providing unique analysis opportunities and techniques.

NEURAL COMPUTING & APPLICATIONS (2022)

Article Computer Science, Interdisciplinary Applications

DataSifter II: Partially synthetic data sharing of sensitive information containing time-varying correlated observations

Nina Zhou, Lu Wang, Simeone Marino, Yi Zhao, Ivo D. Dinov

Summary: This study presents a partially synthetic data generation technique for creating anonymized data archives that closely resemble the original sensitive data. This technique reduces the risk of re-identification while preserving the analytical value of the obfuscated data. It provides an automated tool for effective and collaborative analytics for large time-varying datasets containing sensitive information.

JOURNAL OF ALGORITHMS & COMPUTATIONAL TECHNOLOGY (2022)

Article Computer Science, Interdisciplinary Applications

Precision radiotherapy via information integration of expert human knowledge and AI recommendation to optimize clinical decision making

Wenbo Sun, Dipesh Niraula, Issam El Naqa, Randall K. Ten Haken, Ivo Dinov, Kyle Cuneo, Judy (Jionghua) Jin

Summary: This paper presents a systematic method to integrate expert human knowledge with AI recommendations for optimizing clinical decision making. It combines Gaussian process models with deep neural networks to quantify the uncertainty of treatment outcomes given by physicians and AI recommendations, providing guidance for clinical physicians and improving AI models performance.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2022)

Article Public, Environmental & Occupational Health

The clusters of health-risk behaviours and mental wellbeing and their sociodemographic correlates: a study of 15,366 ASEAN university students

Apichai Wattanapisit, Hanif Abdul Rahman, Josip Car, Khadizah Haji Abdul-Mumin, Ma. Henrietta Teresa O. de la Cruz, Michael Chia, Michael Rosenberg, Moon-ho Ringo Ho, Surasak Chaiyasong, Trias Mahmudiono, Yuvadee Rodjarkpai, Ivo D. Dinov, Mohammad Ottom, Areekul Amornsriwatanakul

Summary: This study examines the associations between behavioral characteristics, mental wellbeing, demographic characteristics, and health among university students in the ASEAN University Network - Health Promotion Network. Through cluster analysis, the study identifies five clusters of student-types with distinct health behaviors. The findings suggest that interventions should focus on the dominant health-risk behavior, with consideration given to the associated health-risk behaviors within clusters.

BMC PUBLIC HEALTH (2022)

Article Neurosciences

Brain structure and allelic associations in Alzheimer's disease

Seok Woo Moon, Lu Zhao, William Matloff, Sam Hobel, Ryan Berger, Daehong Kwon, Jaebum Kim, Arthur W. W. Toga, Ivo D. D. Dinov

Summary: This study examined the association between genetic and neuroimaging biomarkers in late-onset dementia-related cognitive impairment. The results showed significant correlations between specific genomic markers and neuroimaging markers, and identified key markers for distinguishing Alzheimer's disease and mild cognitive impairment.

CNS NEUROSCIENCE & THERAPEUTICS (2023)

Article Oncology

Machine learning-based colorectal cancer prediction using global dietary data

Hanif Abdul Rahman, Mohammad Ashraf Ottom, Ivo D. Dinov

Summary: This study aimed to evaluate machine learning algorithms in large-scale datasets, taking into account both younger and older adults from various regions and sociodemographics. The study found that a prediction model based on an artificial neural network performed well in predicting CRC and non-CRC phenotypes.

BMC CANCER (2023)

Article Multidisciplinary Sciences

A clinical decision support system for AI-assisted decision-making in response-adaptive radiotherapy (ARCliDS)

Dipesh Niraula, Wenbo Sun, Jionghua Jin, Ivo D. Dinov, Kyle Cuneo, Jamalina Jamaluddin, Martha M. Matuszak, Yi Luo, Theodore S. Lawrence, Shruti Jolly, Randall K. Ten Haken, Issam El Naqa

Summary: This study developed an artificial intelligence-based decision-making framework to assist in dynamic treatment regimes (DTR) for oncology. The framework utilizes advanced machine learning analytics and information-rich multi-omics data to overcome the challenges posed by various variables, treatment response uncertainty, and patient heterogeneity. The framework, demonstrated in Knowledge Based Response-Adaptive Radiotherapy (KBR-ART) applications, consists of two main components and has shown promising results in improving clinical decision-making and treatment outcomes.

SCIENTIFIC REPORTS (2023)

Article Psychiatry

Generalizable prediction of childhood ADHD symptoms from neurocognitive testing and youth characteristics

Alexander Weigard, Katherine L. McCurry, Zvi Shapiro, Meghan E. Martz, Mike Angstadt, Mary M. Heitzeg, Ivo D. Dinov, Chandra Sripada

Summary: This study developed and tested machine learning models to predict ADHD symptoms in children using neurocognitive abilities, demographics, and child and family characteristics. The models explained 15-20% of the variance in 1-year ADHD symptoms and 12-13% of the variance in 2-year ADHD symptoms. The models showed high generalizability and minimal predictive power loss when applied to new data.

TRANSLATIONAL PSYCHIATRY (2023)

Article Pharmacology & Pharmacy

Classifying migraine using PET compressive big data analytics of brain's mu-opioid and D2/ D3 dopamine neurotransmission

Simeone Marino, Hassan Jassar, Dajung J. J. Kim, Manyoel Lim, Thiago D. D. Nascimento, Ivo D. D. Dinov, Robert A. A. Koeppe, Alexandre F. F. DaSilva

Summary: This study utilized a novel machine learning method to accurately identify migraine patients based on the analysis of central mu-opioid and dopamine D2/D3 receptors. The results showed that dysfunction in the μ-opioid and D2/D3 receptors in the neurotransmission of migraine patients may partly explain the severe impact of migraine and associated neuropsychiatric comorbidities.

FRONTIERS IN PHARMACOLOGY (2023)

Article Biotechnology & Applied Microbiology

Multimodal Stereotactic Brain Tumor Segmentation Using 3D-Znet

Mohammad Ashraf Ottom, Hanif Abdul Rahman, Iyad M. Alazzam, Ivo D. Dinov

Summary: This study proposes an enhanced deep neural network approach, the 3D-Znet model, for segmenting brain tumors based on 3D neuroimaging data. It provides automated tumor diagnostics and can help in early tumor diagnosis, potentially saving lives.

BIOENGINEERING-BASEL (2023)

Article Biotechnology & Applied Microbiology

Machine Learning-Based Prediction of Mental Well-Being Using Health Behavior Data from University Students

Hanif Abdul Rahman, Madeline Kwicklis, Mohammad Ottom, Areekul Amornsriwatanakul, Khadizah H. Abdul-Mumin, Michael Rosenberg, Ivo D. Dinov

Summary: This study utilized machine learning algorithms and artificial intelligence techniques to assess mental well-being and identified the most significant features associated with it. The findings are of great importance for providing cost-effective support and modernizing mental well-being assessment at both individual and university levels.

BIOENGINEERING-BASEL (2023)

Meeting Abstract Oncology

A Decision Support Software for AI-Assisted Decision Making in Response-Adaptive Radiotherapy - An Evaluation Study

D. Niraula, W. Sun, J. Jin, I. D. Dinov, K. C. Cuneo, J. Jamaluddin, M. M. Matuszak, R. K. Ten Haken, I. El Naqa

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Article Health Care Sciences & Services

DataSifterText: Partially Synthetic Text Generation for Sensitive Clinical Notes

Nina Zhou, Qiucheng Wu, Zewen Wu, Simeone Marino, Ivo D. Dinov

Summary: This article introduces a new method called DataSifterText, which can generate partially synthetic clinical free-text and provides high utility preservation while protecting privacy. Experiments have shown that this method is superior to traditional content suppression methods in terms of privacy protection and information preservation.

JOURNAL OF MEDICAL SYSTEMS (2022)

Article Engineering, Biomedical

Znet: Deep Learning Approach for 2D MRI Brain Tumor Segmentation

Mohammad Ashraf Ottom, Hanif Abdul Rahman, Ivo D. Dinov

Summary: This paper presents a novel framework for segmenting brain tumors in MR images using deep neural networks and data augmentation strategies. The experimental results demonstrate high performance of the proposed method in localizing and segmenting brain tumors in MR images.

IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE (2022)

暂无数据