Article
Clinical Neurology
Sophie Paredis, Lisa van Stiphout, Eva Remmen, Michael Strupp, Marie-Cecile Gerards, Herman Kingma, Vincent Van Rompaey, Angelica-Perez Fornos, Nils Guinand, Raymond van de Berg
Summary: This study assessed the prevalence of various symptoms in bilateral and unilateral vestibulopathy patients using the DISCOHAT acronym, finding that bilateral patients reported more severe symptoms. The acronym proved to be a quick and effective tool for comprehensive assessment, potentially improving uniformity in vestibular clinics worldwide.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Hermann Ruben, Robert Camille, Lagadec Vincent, Dupre Mathieu, Pelisson Denis, Froment Tilikete Caroline
Summary: This study aimed to evaluate the impact of cerebellar pathology on compensatory fast eye movements in patients with bilateral vestibular hypofunction. The results showed that patients with additional cerebellar dysfunction had longer latency in the first catch-up saccade, suggesting the involvement of the cerebellum in this process.
Review
Clinical Neurology
Mustafa Karabulut, Lien Van Laer, Ann Hallemans, Luc Vereeck, Vincent Van Rompaey, Wolfgang Viechtbauer, Ali Melliti, Lisa van Stiphout, Alfarghal Mohamad, Angelica Perez Fornos, Nils Guinand, Raymond van de Berg
Summary: A systematic review and meta-analysis were conducted to evaluate the self-reported chronic symptoms in patients with unilateral vestibular hypofunction (UVH) and the effect of interventions on these symptoms. The study found that the most frequently reported symptoms in UVH patients include chronic dizziness, imbalance, symptoms worsened by head movements, visually induced dizziness, symptoms worsened in darkness, and oscillopsia. Self-report questionnaires showed that UVH had a moderate negative impact on patients' quality of life, but vestibular interventions could significantly reduce this impact, although a subgroup of patients still experienced moderate handicap.
FRONTIERS IN NEUROLOGY
(2023)
Article
Otorhinolaryngology
P. Reynard, E. Ionescua, J. Ortega Solis, S. Idrissa, H. Thai-Vana
Summary: This article reports three cases of patients with bilateral vestibulopathy (BV) who meet the Barany criteria but are still disabled by intense vertigo. The study suggests that maintaining a stable otolithic reference frame in BV patients can help optimize postural strategy.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Otorhinolaryngology
Mahmut Sinan Yilmaz, Oguz Kadir Egilmez, Ahmet Kara, Mehmet Guven, Deniz Demir, Sena Genc Elden
Summary: The study found that caloric testing is more sensitive for detecting VOR pathology in patients with Meniere's disease compared to those with vestibular migraine, although video head impulse testing can provide complementary information. Abnormalities were more common in caloric testing for Meniere's disease, while abnormalities in video head impulse testing were more common in vestibular migraine patients.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Clinical Neurology
Lisa van Stiphout, Maksim Pleshkov, Florence Lucieer, Bieke Dobbels, Vergil Mavrodiev, Nils Guinand, Angelica Perez Fornos, Josine Widdershoven, Michael Strupp, Vincent Van Rompaey, Raymond van de Berg
Summary: This study found that caloric testing and vHIT are more sensitive in measuring vestibular impairment, while the torsion swing test is better for assessing residual vestibular function. There was no clear pattern of vestibular impairment related to etiology. However, despite stricter implantation criteria, 76% of BVP patients were still eligible for vestibular implantation based on the test criteria.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Augusto Pietro Casani, Francesco Lazzerini, Ottavia Marconi, Nicola Vernassa
Summary: The study suggests that the results of the fHIT with and without OB can help identify the presence of dynamic visual dependence in patients with VM. Additionally, significant differences were found in %CA with and without OB in the AUV group, indicating the potential utility of fHIT in clinical practice for correctly identifying subjects suffering from VM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Mathieu Dupre, Ruben Hermann, Caroline Froment Tilikete
Summary: CANVAS is a rare neurological syndrome characterized by late-onset cerebellar ataxia and bilateral vestibular dysfunction first described by the neurootology/neurophysiology community. The syndrome involves deficits in the visuo-vestibulo-ocular reflex and peripheral sensory axonal neuropathy. Its genetic etiology was discovered in 2019 as abnormal biallelic expansion in the RFC1 gene.
Article
Clinical Neurology
I. P. Hannigan, S. M. Rosengren, G. K. Bharathy, M. Prasad, M. S. Welgampola, S. R. D. Watson
Summary: The study found that patients with vestibular migraine have higher nystagmus slow-phase velocity and subjective symptoms during caloric testing compared to patients with other vestibular disorders. Combining objective and subjective measures can provide better differentiation of vestibular migraine from Meniere's disease.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ming Li, Yangming Leng, Bo Liu
Summary: Vestibular manifestations in patients with enlarged vestibular aqueduct (EVA) can include reduced caloric response and normal horizontal vHIT. The pattern of angular VOR impairment observed in EVA patients with vertigo is similar to that found in other hydropic ear diseases, with diminished caloric responses and normal vHIT being common.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Max Wuehr, Josefine Eder, Aram Keywan, Klaus Jahn
Summary: In patients with bilateral vestibulopathy, imperceptible noisy galvanic vestibular stimulation (nGVS) has been found to improve impaired vestibular motion perception, especially in patients with poor baseline perceptual performance. This non-invasive vestibular noise stimulation offers a potential approach to target spatial memory, orientation, and navigation impairments associated with bilateral vestibulopathy.
JOURNAL OF NEUROLOGY
(2023)
Article
Otorhinolaryngology
Maiko Yamakawa, Kayoko Kabaya, Akina Fukushima, Shinobu Ito, Shinichi Iwasaki
Summary: We describe a novel type of idiopathic bilateral vestibulopathy characterized by acute simultaneous involvement of the low-frequency range vestibulo-ocular reflex deficit.
AURIS NASUS LARYNX
(2022)
Article
Clinical Neurology
Josefine Eder, Silvy Kellerer, Tamara Amberger, Aram Keywan, Julia Dlugaiczyk, Max Wuehr, Klaus Jahn
Summary: There is no synergistic treatment effect when noisy galvanic vestibular stimulation (nGVS) is combined with vestibular rehabilitation training (VRT) in patients with bilateral vestibulopathy (BVP). However, nGVS may be used as a complementary therapeutic option during postural activities in daily life.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Desi. P. Schoo, Andrianna. I. Ayiotis, Celia Fernandez Brillet, Margaret. R. Chow, Kelly. E. Lane, Bryan. K. Ward, John. P. Carey, Charles. C. Della Santina
Summary: This study investigated the use of prosthetic stimulation via a vestibular implant to generate artificial sensation of head movement in a patient with long-standing bilateral vestibular hypofunction. The results showed that even after 23 years of illness, the implant was able to elicit eye movement responses that aligned with specific semicircular canals. This research suggests that vestibular implantation can be a viable option for improving the quality of life in patients with vestibular hypofunction.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Clinical Neurology
Qin Zhang, Qiong Wu, Jianyong Chen, Xueyan Wang, Yuzhong Zhang, Shuyun Liu, Lu Wang, Jiali Shen, Min Shen, Xinyi Tang, Ling Mei, Xiangping Chen, Yulian Jin, Jun Yang, Qing Zhang
Summary: ObjectiveVertigo, a common condition in children, lacks clear diagnosis and characteristics. This study analyzed the features of caloric test (CT) and video head impulse test (vHIT) in vestibular migraine of childhood (VMC), probable vestibular migraine of childhood (PVMC), and recurrent vertigo of childhood (RVC). The study found that neither CT nor vHIT were specific to these conditions, and the diagnosis relied more on symptoms and clinical characteristics.
FRONTIERS IN NEUROLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Dmitrii Starkov, Nils Guinand, Florence Lucieer, Maurizio Ranieri, Samuel Cavuscens, Maksim Pleshkov, Jean-Philippe Guyot, Herman Kingma, Stefano Ramat, Angelica Perez-Fornos, Raymond van de Berg
AUDIOLOGY AND NEURO-OTOLOGY
(2020)
Article
Otorhinolaryngology
Joost Johannes Antonius Stultiens, Alida Annechien Postma, Nils Guinand, Angelica Perez Fornos, Hermanus Kingma, Raymond van de Berg
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
(2020)
Review
Genetics & Heredity
Maria Teresa Carminho-Rodrigues, Phillipe Klee, Sacha Laurent, Michel Guipponi, Marc Abramowicz, Helene Cao-van, Nils Guinand, Ariane Paoloni-Giacobino
BMC MEDICAL GENETICS
(2020)
Article
Engineering, Biomedical
Celine Cretallaz, Anissa Boutabla, Samuel Cavuscens, Maurizio Ranieri, T. A. Khoa Nguyen, Herman Kingma, Raymond Van de Berg, Nils Guinand, Angelica Perez Fornos
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Clinical Neurology
Joost J. A. Stultiens, Nils Guinand, Vincent Van Rompaey, Angelica Perez Fornos, Henricus P. M. Kunst, Hermanus Kingma, Raymond van de Berg
Summary: The study evaluated the evolution of vestibular function and hearing after plugging of a semicircular canal, showing that most patients experience recovery during follow-up, but some may persist with vestibular function loss or high-frequency hearing loss.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Lisa van Stiphout, Florence Lucieer, Maksim Pleshkov, Vincent Van Rompaey, Josine Widdershoven, Nils Guinand, Angelica Perez Fornos, Herman Kingma, Raymond van de Berg
Summary: The study found that perceptual self-motion thresholds are significantly higher in patients with bilateral vestibulopathy compared to control subjects, and are generally associated with lower vestibular test results.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Dmitrii Starkov, Bernd Vermorken, T. S. Van Dooren, Lisa Van Stiphout, Miranda Janssen, Maksim Pleshkov, Nils Guinand, Angelica Perez Fornos, Vincent Van Rompaey, Herman Kingma, Raymond van de Berg
Summary: This study found that in healthy subjects, higher predictability in head movements led to lower VOR gain only in passive impulses, while active impulses may result in shorter compensatory saccadic latencies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Lisa van Stiphout, Florence Lucieer, Nils Guinand, Angelica Perez Fornos, Maurice van de Berg, Vincent Van Rompaey, Josine Widdershoven, Herman Kingma, Manuela Joore, Raymond van de Berg
Summary: This study showed that patient expectations for a vestibular implant focus on three key themes: symptom reduction, functions and activities, and quality of life. These themes closely align with the functional improvements observed in recent vestibular implantation research. The results provide valuable guidance for future vestibular implant research in terms of characteristics of bilateral vestibulopathy.
JOURNAL OF NEUROLOGY
(2022)
Article
Otorhinolaryngology
Olivier Peetermans, Bieke Dobbels, Griet Mertens, Julie Moyaert, Raymond van de Berg, Olivier Vanderveken, Paul Van de Heyning, Angelica Perez Fornos, Nils Guinand, Marc J. W. Lammers, Vincent Van Rompaey
Summary: The aim of this study was to evaluate the impact of bilaterally (partially) absent vestibular function on sound localization skills during static conditions. The results showed that patients with bilateral vestibulopathy had slightly worse static sound localization skills compared to healthy controls, but the difference was very small and likely due to impaired cognitive function. The vestibular system does not seem to play a significant role in sound localization during static conditions, and subjective reporting of speech perception, spatial hearing, and quality of life were not strongly correlated with localization scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Tessa van Dooren, Dmitrii Starkov, Florence Lucieer, Bieke Dobbels, Miranda Janssen, Nils Guinand, Angelica Perez Fornos, Herman Kingma, Vincent van Rompaey, Raymond van de Berg
Summary: The study compared the Suppression Head Impulse (SHIMP) test and the Head Impulse Paradigm (HIMP) in diagnosing Bilateral Vestibulopathy (BV). Results showed that SHIMP reduced covert saccades compared to HIMP, but there was no significant difference in VOR gain. Both paradigms had a high agreement in diagnosing BV.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Jelena Todic, Nils Guinand, Vincent Lenoir, Pascal Senn, Minerva Becker
Summary: This study evaluated the clinical significance of MRI findings and their prognostic value for initial hearing loss and recovery in patients with sudden sensorineural hearing loss (SSNHL). The study found that age > 70 years and CNS lesions independently predicted poor auditory recovery.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Clinical Neurology
Meichan Zhu, Lisa van Stiphout, Mustafa Karabulut, Angelica Perez Fornos, Nils Guinand, Kenneth Meijer, Raymond van de Berg, Christopher McCrum
Summary: Bilateral vestibulopathy (BVP) causes unsteadiness in walking, especially in darkness or on uneven ground, leading to falls. The study found that the Mini-BESTest is feasible in BVP, with participants scoring significantly lower than healthy participants. The negative correlation between age and balance is more significant in BVP.
JOURNAL OF NEUROLOGY
(2023)