Article
Immunology
Y. F. van Lier, L. Krabbendam, N. J. E. Haverkate, S. S. Zeerleder, C. E. Rutten, B. Blom, H. Spits, M. D. Hazenberg
Summary: Innate lymphoid cells (ILCs) are important regulators of immune response in barrier tissues, playing roles in protection against pathogens, maintaining epithelial integrity, regulating immune responses, and shaping the gut microbiota. GATA2 haploinsufficiency, a condition characterized by bone marrow failure and deficiency of certain immune cells, results in the absence of ILCs and their progenitors. However, after allogeneic hematopoietic stem cell transplantation, all subsets of ILCs appear, suggesting the involvement of GATA2 in the development of hematopoietic precursor cells (HPC) towards the ILC lineage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Christelle Piperoglou, Guillaume Larid, Blandine Vallentin, Laura Balligand, Adeline Crinier, Nathalie Banzet, Catherine Farnarier, Elena Gomez-Massa, Aranzazu Cruz Adalia, Gerard Michel, Claire Galambrun, Vincent Barlogis, Eric Vivier, Frederic Vely
Summary: Research found that after hematopoietic stem cell transplantation, helper-like innate lymphoid cells (ILCs) recover slowly, similar to T cells, taking about a year to normalize. The type of graft and the proportion of CD34(+) cells in the graft did not significantly affect ILC reconstitution. Furthermore, it was discovered that lower levels of activated and gut-homing ILC subset were associated with graft-versus-host disease, suggesting a crucial role of this subset in preventing the disorder.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Developmental Biology
Atesh K. Worthington, Taylor Cool, Donna M. Poscablo, Adeel Hussaini, Anna E. Beaudin, E. Camilla Forsberg
Summary: This study further investigated the development of tissue-resident lymphoid cells (TLCs) in mice and explored the roles of two cytokine receptors, Flk2 and IL7R alpha, in traditional lymphopoiesis. The findings revealed the essential role of IL7R alpha in the generation of TLCs.
Article
Immunology
Ane Orrantia, Inigo Terren, Gabirel Astarloa-Pando, Carmen Gonzalez, Alasne Uranga, Juan J. Mateos-Mazon, Juan C. Garcia-Ruiz, Marta Rinon, Mercedes Rey, Silvia Perez-Fernandez, Olatz Zenarruzabeitia, Francisco Borrego
Summary: AutoHSCT in MM patients leads to significant changes in NK cell subsets and phenotype, with patients showing lower frequencies of the mature NKG2A-CD57+ NK cell subset experiencing better clinical outcomes. This suggests that the degree of NK cell maturation post-autoHSCT affects the disease progression and treatment outcomes in MM patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Josefine Ruder, Jordan Rex, Simon Obahor, Maria Jose Docampo, Antonia M. S. Mueller, Urs Schanz, Ilijas Jelcic, Roland Martin
Summary: It was found that after autologous hematopoietic stem cell transplantation, the relative frequency and absolute numbers of CD56(bright) NK cells in patients with multiple sclerosis increased, while all studied innate-like T cell populations decreased.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hongfeng Huang, Qixia Shen, Jingyi Zhou, Xiuyan Yang, Qiuqin Cai, Jia Shen, Shi Feng, Wenqing Xie, Hong Jiang, Jianghua Chen
Summary: The clinical experience demonstrates the efficacy of non-myeloablative conditioning protocol in inducing tolerance in HLA identical patients, and complete chimerism may be a risk factor for GVHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amrita Kumar, Weiping Cao, Kedan Endrias, Suresh V. Kuchipudi, Suresh K. Mittal, Suryaprakash Sambhara
Summary: Innate Lymphoid Cells play a critical role in clearing pathogens in mammalian hosts and are particularly important in response to viral infections.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Immunology
Masahiro Miyata, Kazunobu Ichikawa, Eri Matsuki, Masafumi Watanabe, Daniel Peltier, Tomomi Toubai
Summary: Acute kidney injury is a common complication of allogeneic hematopoietic cell transplantation and can be caused by multiple factors. Recent studies suggest that graft-versus-host disease may attack the kidneys and contribute to the development of renal injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hobin Seo, Amisha Verma, Megan Kinzel, Qiutong Huang, Douglas J. J. Mahoney, Nicolas Jacquelot
Summary: Reinvigorating the killing function of tumor-infiltrating immune cells through targeting regulatory molecules has improved the prognosis of cancer patients. Recent investigations suggest that tissue-resident innate lymphoid cells (ILCs), in addition to T lymphocytes, can benefit from immunotherapy. This article discusses the expression of immune checkpoint on ILCs and how their effector function is modulated by checkpoint blockade-based therapies, exploring potential to impede tumor growth and disease progression.
Review
Immunology
Aurelie S. Clottu, Morgane Humbel, Natalia Fluder, Maria P. Karampetsou, Denis Comte
Summary: Innate lymphoid cells (ILC) are a group of immune cells similar to T cells in morphology and cytokine profile, but they lack clonally distributed diverse antigen receptors. ILC, especially ILC1, ILC2, and ILC3, express transcription factors and cytokines similar to T helper cells, and play an important role in innate immunity by responding rapidly to pathogens. Recent studies have shown that alterations in the number and function of ILC are associated with autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Laura Kiekens, Sigrid Wahlen, Eva Persyn, Zenzi De Vos, Tom Taghon, Bart Vandekerckhove, Georges Leclercq
Summary: The study demonstrates that human ILC3s can convert into functional NK cells, with T-BET being the main driver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Daniela Carolina Hernandez, Kerstin Juelke, Nils Christian Mueller, Pawel Durek, Bilge Ugursu, Mir-Farzin Mashreghi, Timo Rueckert, Chiara Romagnani
Summary: This study developed a platform to generate human ILC lineages from CD34(+) hematopoietic progenitors, providing a valuable resource for clarifying ILC biology and differentiation. The generation of NK/ILC1s, ILC2s, and ILC3s in vitro was validated by protein expression, functional assays, and transcriptome analysis, reflecting the characteristics of their ex vivo counterparts.
Article
Biochemistry & Molecular Biology
Yetao Wang, Lawrence Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela StLouis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, Jeremy Luban
Summary: Innate lymphoid cells (ILCs) are a diverse population of cells that include NK cells and play important roles in tissue homeostasis and repair, inflammation, and protection from infection. This study used transcriptional and chromatin profiling to investigate the interplay between human blood ILCs and their responses to HIV-1 infection. The findings reveal the existence of four main ILC subsets in human blood and provide insights into how HIV-1 infection disrupts NK cells and their homeostatic function.
Article
Pediatrics
Tomasz Jarmolinski, Monika Rosa, Blanka Rybka, Renata Ryczan-Krawczyk, Kornelia Gajek, Katarzyna Bogunia-Kubik, Maja Klaudel-Dreszler, Piotr Czubkowski, Piotr Kalicinski, Joanna Teisseyre, Marek Stefanowicz, Ewa Gorczynska, Krzysztof Kalwak, Marek Ussowicz
Summary: A child with Fanconi anemia underwent orthotopic liver transplantation (OLT) after hematopoietic stem cell transplantation (HSCT) complicated by acute graft versus host disease (GVHD). The liver can serve as a clinically significant source of hematopoietic stem cells. Close monitoring of hematopoietic chimerism after OLT is necessary in patients at risk for complications such as GVHD.
FRONTIERS IN PEDIATRICS
(2022)
Review
Cell & Tissue Engineering
Maja Stanojevic, Alice Bertaina, Carmem Bonfim, Rachele Ciccocioppo, Sandra Cohen, Duncan Purtill, Annalisa Ruggeri, Athena Russell, Akshay Sharma, Robert Wynn, Jaap Jan Boelens, Susan Prockop, Allistair Abraham
Summary: Despite advances in HSCT, viral infections remain a significant cause of morbidity and mortality for recipients. Adoptive transfer of viral specific T cells has been successfully used for prevention and treatment of viral infections in immunocompromised HSCT recipients. Precise risk stratification should consider pretransplant clinical criteria and immune reconstitution milestones to identify those at highest risk. Early detection and treatment of viral reactivation is challenging in regions without readily available commercial PCR assays and antiviral agents.
Meeting Abstract
Hematology
Roshani Sinha, Rachana Patil, Rosa Romano, Esmond Lee, Zhenyu Yao, Y. Lucy Liu, Matthew H. Porteus, Alice Bertaina
Article
Cell & Tissue Engineering
Orly R. Klein, Carmem Bonfim, Allistair Abraham, Annalisa Ruggeri, Duncan Purtill, Sandra Cohen, Robert Wynn, Athena Russell, Akshay Sharma, Rachele Ciccocioppo, Susan Prockop, Jaap Jan Boelens, Alice Bertaina
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for many non-malignant disorders. This article reviews various aspects of HSCT for patients with non-malignant disorders, including transplant considerations, conditioning regimens, donor choice, and graft manipulation strategies.
Article
Oncology
Erik S. Blomain, Alice Jiang, Sarah S. Donaldson, Rajni Agarwal, Alice Bertaina, David Shyr, Michael L. Eisenberg, Richard T. Hoppe, Susan M. Hiniker, Justin Oh
Summary: This study compared the effects of testicular boost irradiation in children with leukemia undergoing hematopoietic stem cell transplant. The results showed that testicular boost did not reduce the risk of relapse, but resulted in a higher rate of gonadal dysfunction.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Moises Garcia-Rosa, Allistair Abraham, Alice Bertaina, Senthil Velan Bhoopalan, Carmem Bonfim, Sandra Cohen, Amy DeZern, Chrystal Louis, Joseph Oved, Mara Pavel-Dinu, Duncan Purtill, Annalisa Ruggeri, Athena Russell, Akshay Sharma, Robert Wynn, Jaap Jan Boelens, Susan Prockop
Summary: Allogeneic hematopoietic stem cell transplant is an effective treatment for various blood diseases, but graft-versus-host disease (GVHD) is still a major concern. Current pharmacologic agents used to prevent and treat GVHD also affect the graft-versus-leukemia effect. Cellular therapies such as mesenchymal stromal cells and regulatory T cells show potential in preventing or treating GVHD. Clinical studies are ongoing to explore the role of these therapies in improving GVHD-related outcomes.
Article
Oncology
Raul Montiel-Esparza, Suzanne M. Michalak, Anthony Huy Dinh Le, Christopher Or, Quan Dong Nguyen, Ruby Khoury, Michael S. Grimley, Alice Bertaina, Edna Klinger, Ami J. Shah, Edward H. Wood
Summary: Cytomegalovirus retinitis (CMVR) is a rare but severe complication following hematopoietic stem cell transplantation (HCT), which can lead to irreversible consequences despite optimal antiviral treatment. Viral-specific T cells (VSTs) offer a promising and safe approach for eliminating stubborn viral diseases. We present the case of a 21-month-old male with Wiskott-Aldrich syndrome (WAS) and CMVR post HCT, showing sustained long-term virologic and clinical improvement after CMV-specific T-cell therapy. This case emphasizes the importance of considering VST as an adjunct upfront strategy for refractory CMVR, as well as the need for regular ophthalmologic screening and surveillance in high-risk patients post HCT.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Medicine, General & Internal
Steven Levitte, Abantika Ganguly, Sophie Frolik, Alix A. Guevara-Tique, Shaini Patel, Ann Tadas, Orly Klein, David Shyr, Rajni Agarwal-Hashmi, Lynn Beach, Elizabeth Callard, Katja Weinacht, Alice Bertaina, Avnesh S. Thakor
Summary: Graft versus host disease (GVHD) is a serious complication in pediatric stem cell transplant patients. Corticosteroids are the main treatment, but their long-term use can cause complications. Intraarterial steroid administration has been successfully used in children with GVHD, improving symptoms and liver function. This approach may be considered as a rescue or bridge therapy for children with acute GVHD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Roshani Sinha, Mai Dvorak, Ananthakrishnan Ganesan, Larry Kalesinskas, Charlotte M. Niemeyer, Christian Flotho, Kathleen M. Sakamoto, Norman Lacayo, Rachana Vinay Patil, Rhonda Perriman, Alma-Martina Cepika, Yunying Lucy Liu, Alex Kuo, Paul J. Utz, Purvesh Khatri, Alice Bertaina
Summary: This study identifies potential druggable targets for the treatment of JMML through the analysis of DNA structures and histone modifications, providing a rich resource for improving the outcomes of JMML patients.
Meeting Abstract
Pediatrics
Paul Charles Grimm, Cynthia Wong, Debra Jordi Goldstein-Fuchs, Abanti Chaudhuri, Gerri James, Darcy Boyd, Julie Good, Mayna Woo, Amy Gallo, Alice Bertaina
PEDIATRIC NEPHROLOGY
(2023)
Meeting Abstract
Critical Care Medicine
Vijith Vijayan, Hao Yan, Juliane Lohmeyer, Kolten Peterson, James Harden, Rachana Patil, Giulia Barbarito, Alice Bertaina, Robert Negrin, Daria Mochly-Rosen, Kenneth Weinberg, Bereketeab Haileselassie
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
G. Barbarito, D. M. Louis, R. Patil, R. Sinha, L. Oppizzi, Z. Yao, K. Weinberg, R. Parkman, A. Bertaina
Meeting Abstract
Cell & Tissue Engineering
A. Bertaina, R. Bacchetta, D. C. Shyr, G. Saini, J. Lee, K. Kristovich, R. Agarwal, O. Klein, K. Melsop, K. Tate, G. Barbarito, L. Oppizzi, P. Chen, A. Cepika, M. Roncarolo
Meeting Abstract
Biophysics
G. Lucchini, A. Bertaina, J. E. Galimard, M. Benakli, K. Kalwak, J. H. Dalle, O. Mirci Danicar, M. Ayas, F. Locatelli, E. Skorobogatova, Y. Bertrand, J. Styczynski, A. Tbakhi, P. Sedlacek, A. Balduzzi, M. Ifversen, B. Versluijs, C. Jubert, A. Dalissier, P. Bader, S. Corbacioglu
BONE MARROW TRANSPLANTATION
(2022)
Meeting Abstract
Biophysics
A. Bertaina, K. Osoegawa, K. M. Cunanan, S. Spellman, M. Fernandez-Vina
BONE MARROW TRANSPLANTATION
(2022)
Letter
Medicine, General & Internal
Alice Bertaina, Paul C. Grimm, Kenneth Weinberg
NEW ENGLAND JOURNAL OF MEDICINE
(2022)