Article
Immunology
Edgar Alonso Melgoza-Gonzalez, Monica Resendiz-Sandoval, Diana Hinojosa-Trujillo, Sofia Hernandez-Valenzuela, Melissa Garcia-Vega, Veronica Mata-Haro, Araceli Tepale-Segura, Laura C. Bonifaz, Armando Perez-Torres, Jesus Hernandez
Summary: The research demonstrated the ability of rAb ZH9F7 to target and trigger internalization in dendritic cells, promoting their migration in vivo. The antigenized rAb ZH9F7-Cap induced a higher frequency of IFN-gamma-secreting CD4(+)CD8(+) T lymphocytes and antibodies against the Cap protein.
Article
Immunology
Fernando Bandeira Sulczewski, Larissa Alves Martino, Davi Salles, Marcio Massao Yamamoto, Daniela Santoro Rosa, Silvia Beatriz Boscardin
Summary: In this study, the researchers investigated the role of the STAT3 signaling pathway in the ability of different types of dendritic cells to prime CD4(+) T cell responses. They found that STAT3 signaling pathway regulates the function of cDC1 to promote Th1 and Th1-like Tfh cell responses, but does not control the ability of cDC2 to promote Tfh cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xinting Wang, Hua Zhou, Qian Liu, Peipei Cheng, Tingyao Zhao, Tianshu Yang, Yue Zhao, Wanjing Sha, Yanyan Zhao, Huiyan Qu
Summary: Cardiovascular diseases (CVDs) are a major cause of global death and disability, with inflammatory progression and immune responses playing a crucial role. Regulatory T cells (Tregs), as a subset of CD4(+)T cells, have immunosuppressive function and are important in inflammatory diseases. Using Tregs as biomarkers or targeting them for cardioprotective effects by regulating immune balance, suppressing inflammation, and promoting cardiac regeneration has become a research focus in CVD treatment. However, Tregs have plasticity and can lose their immunosuppressive function, causing toxic effects on target organs in certain diseases. This review provides an overview of Tregs' role in CVDs, discusses their plasticity, and lays a foundation for future studies targeting Tregs in CVD prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Feng Shan, Ashwin Somasundaram, Tullia C. Bruno, Creg J. Workman, Dario A. A. Vignali
Summary: The success of immunotherapy in oncology highlights the important role of the immune system in cancer development. Regulatory T cells (Tregs) play multiple roles in the tumor microenvironment, particularly in suppressing T cell activation. Understanding the subpopulations of Tregs and their functions within the complex networks of the tumor microenvironment is crucial for the development of next-generation immunotherapies.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Noemi Anna Nagy, Fernando Lozano Vigario, Rinske Sparrius, Toni M. M. van Capel, Ronald W. van Ree, Sander Tas, I. Jolanda M. de Vries, Teunis B. H. Geijtenbeek, Bram C. Slutter, Esther de Jong
Summary: Nanomedicine offers a promising platform for manipulating dendritic cells (DCs) and the adaptive immune response. Liposomal vitamin D3 can induce the development of regulatory CD4+ T cells and inhibit the proliferation of memory T cells. It can also suppress the development of Th1 and Th17 cells and stimulate the migration of CD14+ skin DCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Julia Dahlhoff, Hannah Manz, Tim Steinfatt, Julia Delgado-Tascon, Elena Seebacher, Theresa Schneider, Amy Wilnit, Zeinab Mokhtari, Paula Tabares, David Boeckle, Leo Rasche, K. Martin Kortuem, Manfred B. Lutz, Hermann Einsele, Andreas Brandl, Andreas Beilhack
Summary: This study found that Tregs accumulate near malignant plasma cells in the bone marrow of multiple myeloma patients and display an activated phenotype. Short-term depletion of Tregs in mouse models with established multiple myeloma led to a potent immune response mediated by CD8 T cells and NK cells, resulting in complete and stable remission. This preclinical in-vivo study suggests that Tregs may be a promising target for the treatment of multiple myeloma.
Article
Immunology
Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander Merleev, Flavio Vincenti, Emanual Maverakis, Angus W. Thomson, Qizhi Tang
Summary: In this study comparing arTregs expanded ex vivo using different types of antigen-presenting cells, it was found that sDCs stimulated Tregs to expand in much larger numbers. Additionally, sDC-generated arTregs expressed higher levels of CD80, CD86, and T cell-attracting chemokines, indicating their superior expansion-inducing capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Suelen S. Santos, Eline Rampazo, Carlos P. Taborda, Joshua D. Nosanchuk, Silvia B. Boscardin, Sandro R. Almeida
Summary: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a common endemic fungus in Latin American countries. Vaccines targeting strong T cell-mediated immune responses are being developed. The P10 peptide derived from the fungus has shown promise in inducing immune responses when targeted to dendritic cells (DC) with a monoclonal antibody to the DEC205 receptor. In experiments with mice, treatment with the aDEC/P10 chimeric antibody resulted in increased IFN-γ and IL-4 levels, reduced fungal burdens, and normal lung tissue architecture. This strategy shows potential for vaccination and therapy against PCM.
Article
Immunology
Nyerhovwo Obarorakpor, Deep Patel, Reni Boyarov, Nansalmaa Amarsaikhan, Joseph Ray Cepeda, Doreen Eastes, Sylvia Robertson, Travis Johnson, Kai Yang, Qizhi Tang, Li Zhang
Summary: In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IA(g7)) in register 3 (R3), creating a bimolecular IA(g7)/InsulinB:9-23 register 3 conformational epitope (InsB:R3). InsB:R3-specific chimeric antigen receptor (CAR) can guide CAR-expressing CD8 T cells to migrate to the islets and pancreatic lymph nodes. Regulatory T cells (Tregs) specific for an islet antigen can suppress autoimmune reactivity in islets and protect against T1D.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Pablo A. Silveira, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Tsun-Ho Lo, Xinsheng Ju, Hsiao-Ting Chen, Helen Roberts, Daniel G. Baker, Georgina J. Clark
Summary: This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment and found that it can achieve immune suppression and reduce the symptoms of autoimmune rheumatoid arthritis. The treatment selectively depleted mature dendritic cells and induced regulatory dendritic cells and regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
