The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview

NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT

(2015) M. A. Karimi et al.   BLOOD

Impaired thymic expression of tissue-restricted antigens licenses the de novo generation of autoreactive CD4+ T cells in acute GVHD

(2015) S. Dertschnig et al.   BLOOD

A preclinical acute GVHD mouse model based on chemotherapy conditioning and MHC-matched transplantation

(2015) K Riesner et al.   BONE MARROW TRANSPLANTATION

IL-12/15/18-preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation

(2015) Christian M. Hüber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8+T cells

(2015) Jennifer Theiss-Suennemann et al.   JOURNAL OF PATHOLOGY

Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10

(2015) B Lamarthée et al.   Mucosal Immunology

Development of a Minor Histocompatibility Antigen Vaccine Regimen in the Canine Model of Hematopoietic Cell Transplantation

(2015) Steven Lawrence Rosinski et al.   TRANSPLANTATION

Comparing the Immunomodulatory Properties of Bone Marrow, Adipose Tissue, and Birth-Associated Tissue Mesenchymal Stromal Cells

(2015) Philipp Mattar et al.   Frontiers in Immunology

Potential limitations of IL-2 administration for the treatment of experimental acute graft-versus-host disease

(2014) Louis Pérol et al.   IMMUNOLOGY LETTERS

A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody

(2014) S. He et al.   JOURNAL OF IMMUNOLOGY

Acute Graft-Versus-Host Disease of the Kidney in Allogeneic Rat Bone Marrow Transplantation

(2014) Seiichiro Higo et al.   PLoS One

Insights into the pathogenesis of GvHD: what mice can teach us about man

(2014) J. Hülsdünker et al.   TISSUE ANTIGENS

Dynamic changes in cell-surface expression of mannose in the oral epithelium during the development of graft-versus-host disease of the oral mucosa in rats

(2014) Hironori Hanada et al.   BMC Oral Health

Prophylaxis and treatment of GVHD: EBMT–ELN working group recommendations for a standardized practice

(2013) T Ruutu et al.   BONE MARROW TRANSPLANTATION

Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease

(2013) Lynne M. Ball et al.   BRITISH JOURNAL OF HAEMATOLOGY

The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?

(2013) Jacques Galipeau   CYTOTHERAPY

Advances in the treatment of acute graft-versus-host disease

(2013) Liren Qian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity

(2013) Arnab Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells

(2013) T. Wu et al.   JOURNAL OF IMMUNOLOGY

Overcoming Current Limitations in Humanized Mouse Research

(2013) Michael A. Brehm et al.   JOURNAL OF INFECTIOUS DISEASES

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Inhibition of c-Abl and PDGF Receptors for Prevention and Treatment of Murine Sclerodermatous Chronic Graft-versus-Host Disease

(2012) Pawel Zerr et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease

(2012) Arian Laurence et al.   IMMUNITY

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

(2012) Robert R. Jenq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4+ T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host Disease

(2012) J. S. Young et al.   JOURNAL OF IMMUNOLOGY

Optimizing chimerism level through bone marrow transplantation and irradiation to induce long-term tolerance to composite tissue allotransplantation

(2012) Jeng-Yee Lin et al.   JOURNAL OF SURGICAL RESEARCH

Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγnull Mice Display a T-Effector Memory Phenotype

(2012) Niwa Ali et al.   PLoS One

Mesenchymal Stromal Cells Fail to Alleviate Experimental Graft-Versus-Host Disease in Rats Transplanted with Major Histocompatibility Complex-Mismatched Bone Marrow

(2012) S. Zinöcker et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immune Reconstitution and Graft-Versus-Host Reactions in Rat Models of Allogeneic Hematopoietic Cell Transplantation

(2012) Severin Zinöcker et al.   Frontiers in Immunology

Tocilizumab for the Treatment of Steroid Refractory Graft-versus-Host Disease

(2011) William R. Drobyski et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR t in mice

(2011) Y. Yu et al.   BLOOD

Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria

(2011) M. E. D. Flowers et al.   BLOOD

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

(2011) M. Srinivasan et al.   BLOOD

Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells

(2011) H.-J. Shin et al.   BLOOD

Instability of Foxp3 Expression Limits the Ability of Induced Regulatory T Cells to Mitigate Graft versus Host Disease

(2011) A. Beres et al.   CLINICAL CANCER RESEARCH

Mouse models of graft-versus-host disease: advances and limitations

(2011) M. A. Schroeder et al.   Disease Models & Mechanisms

Simultaneous Blockade of Costimulatory Signals CD28-CD80 and CD40-CD154 Combined with Monoclonal Antibody against CD25 Induced a Stable Chimerism and Tolerance without Graft-versus-Host Disease in Rat

(2011) Z.X. Zhu et al.   EUROPEAN SURGICAL RESEARCH

Mesenchymal Stromal Cells for Graft-Versus-Host Disease

(2011) Jakub Tolar et al.   HUMAN GENE THERAPY

Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells

(2011) Stephanie L. Sanos et al.   IMMUNOLOGY

Recent advances in IL-22 biology

(2011) L. A. Zenewicz et al.   INTERNATIONAL IMMUNOLOGY

Kinetics of lymphocyte reconstitution after allogeneic bone marrow transplantation: markers of graft-versus-host disease

(2011) S. Zinocker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression Profiling of Major Histocompatibility and Natural Killer Complex Genes Reveals Candidates for Controlling Risk of Graft versus Host Disease

(2011) Peter Novota et al.   PLoS One

Mesenchymal Stromal Cells Fail to Prevent Acute Graft-versus-Host Disease and Graft Rejection after Dog Leukocyte Antigen-Haploidentical Bone Marrow Transplantation

(2010) Marco Mielcarek et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The DSCs-Expressed CD82 Controls the Invasiveness of Trophoblast Cells via Integrinbeta1/MAPK/MAPK3/1 Signaling Pathway in Human First-Trimester Pregnancy1

(2010) Ming-Qing Li et al.   BIOLOGY OF REPRODUCTION

Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

(2010) Paul L Bollyky et al.   Cellular & Molecular Immunology

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

(2010) I. Tawara et al.   CLINICAL CANCER RESEARCH

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease

(2010) M. M. Heimesaat et al.   GUT

Alloimmune Response Results in Expansion of Autoreactive Donor CD4+ T Cells in Transplants That Can Mediate Chronic Graft-versus-Host Disease

(2010) D. Zhao et al.   JOURNAL OF IMMUNOLOGY

The graft-versus-leukemia effect is mainly restricted to NIH-defined chronic graft-versus-host disease after reduced intensity conditioning before allogeneic stem cell transplantation

(2010) S Thepot et al.   LEUKEMIA

T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms

(2010) Jiali Sun et al.   MOLECULAR THERAPY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

Experimental Graft versus Host Disease in the (BNxLEW)FI rat hybrid: an immunohistochemical study of early disease in oral mucosa

(2010) MJ Peszkowski et al.   ORAL DISEASES

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice

(2010) T. Nabekura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Bone Marrow Transplantation

(2009) Geoffrey R. Hill   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease

(2009) Cristina Iclozan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease

(2009) L. Magro et al.   BLOOD

Imatinib for refractory chronic graft-versus-host disease with fibrotic features

(2009) A. Olivieri et al.   BLOOD

Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells

(2009) C. Becker et al.   BLOOD

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

(2009) S. Sarantopoulos et al.   BLOOD

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Alloantigen-specificde novo-induced Foxp3+Treg revertin vivoand do not protect from experimental GVHD

(2009) Christian Koenecke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Preventive usage of broad spectrum chemokine inhibitor NR58-3.14.3 reduces the severity of pulmonary and hepatic graft-versus-host disease

(2009) Sandra Miklos et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease

(2009) Il-Kang Na et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand

(2009) O. Bohana-Kashtan et al.   JOURNAL OF IMMUNOLOGY

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

A Second Prophylactic MHC-Mismatched Bone Marrow Transplantation Protects Against Rat Acute Myeloid Leukemia (BNML) Without Lethal Graft-Versus-Host Disease

(2009) Janne M. Nestvold et al.   TRANSPLANTATION

Murine Models of Chronic Graft-versus-Host Disease: Insights and Unresolved Issues

(2008) Yu-Waye Chu et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

GVHD after chemotherapy conditioning in allogeneic transplanted mice

(2008) B Sadeghi et al.   BONE MARROW TRANSPLANTATION

Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease

(2008) Andrea T. Badillo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in rats

(2008) Ali Emre Aksu et al.   CLINICAL IMMUNOLOGY

Predominant donor CD103+CD8+ T cell infiltration into the gut epithelium during acute GvHD: a role of gut lymph nodes

(2008) Shu Zhou et al.   INTERNATIONAL IMMUNOLOGY

Mesenchymal Stem Cells Alter Migratory Property of T and Dendritic Cells to Delay the Development of Murine Lethal Acute Graft-Versus-Host Disease

(2008) Hong Li et al.   STEM CELLS

Mouse Models of Bone Marrow Transplantation

(2007) Pavan Reddy et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION