Article
Immunology
Luxin Qiao, Xiao Cui, Lin Jia, Yuxue Gao, Wenjing Wang, Feili Wei, Zhili Zhang, Dexi Chen, Yingmin Ma, Yulin Zhang
Summary: This study used mass cytometry and high-throughput sequencing to analyze the immune response characteristics of patients with Pneumocystis pneumonia (PCP). The results showed that the proportions of immune cells and cytokines in PCP patients changed, and these changes were alleviated after anti-PCP treatment.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Yawen Wang, Kang Li, Weichao Zhao, Yalan Liu, Ting Li, Hu-Qin Yang, Zhaohui Tong, Nan Song
Summary: In this study, the researchers found that glucocorticoids impair the secretion of pro-inflammatory cytokines and metabolites in Pneumocystis-infected mice. Through single-cell RNA sequencing, they identified a group of Mmp12(+) macrophages that are enriched in immunocompetent mice and express pro-inflammatory cytokines. They also found that glucocorticoids weaken the antifungal capacity and functional integrity of macrophages. These findings provide insights into the heterogeneity and metabolic changes of innate immunity in immunocompromised hosts and suggest a role of Mmp12(+) macrophages in the pathogenesis of immunosuppression-associated pneumonitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Hu-Qin Yang, Yi-Shan Wang, Kan Zhai, Zhao-Hui Tong
Summary: This study found that mice infected with Pneumocystis demonstrated reduced TCR diversity in CD4(+) T cells and increased diversity in CD8(+) T cells. Th17 cells were mainly composed of CD4(+) T cells and exhibited the phenotype of tissue-resident memory-like Th17 cells. Additionally, Pneumocystis-infected mice showed biased usage of TCR beta VDJ genes.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tayleur D. White, Abdulaziz Almutairi, Ying Gai Tusing, Xiaoyong Lei, Sasanka Ramanadham
Summary: iPLA(2)beta is involved in various biological processes, activated in several diseases, and plays a role in promoting inflammation, potentially contributing to the development of autoimmune diseases.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Review
Immunology
Kok Fei Chan, Jessica Da Gama Duarte, Simone Ostrouska, Andreas Behren
Summary: γδ T cells play a crucial role in clearing tumors and pathogen-infected cells through their distinct recognition and immune response properties. They interact with other immune cells upon activation, influencing the outcome of immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Feiling Xie, Hongmei Dong, Hao Zhang
Summary: PTPRO/PTPROt, as a member of the PTP family, plays a crucial role in immune cells by regulating their growth, differentiation, activation and immune responses. This review focuses on the regulatory roles and molecular mechanisms of PTPRO/PTPROt in B cells, T cells, and macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hui Zhang, Ulrich Costabel, Huaping Dai
Summary: Sarcoidosis is a systemic inflammatory disorder characterized by tissue infiltration with macrophages and lymphocytes, primarily affecting the lungs. Recent research has highlighted the role of different immune cells, including Th17 cells, IFN-gamma-producing Th17 cells, and regulatory T cells, in the pathogenesis of sarcoidosis. Despite advancements in understanding, the specific actions of these cells and the contribution of neglected cells such as B cells, dendritic cells, natural killer cells, and natural killer T cells remain to be fully clarified. Further research is needed to reveal distinct immunological events and potentially develop new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Peter A. Szabo, Pranay Dogra, Joshua Gray, Steven B. Wells, Thomas J. Connors, Stuart P. Weisberg, Izabela Krupska, Rei Matsumoto, Maya M. L. Poon, Emma Idzikowski, Sinead E. Morris, Chloe Pasin, Andrew J. Yates, Amy Ku, Michael Chait, Julia Davis-Porada, Xinzheng Guo, Jing Zhou, Matthew Steinle, Sean Mackay, Anjali Saqi, Matthew R. Baldwin, Peter A. Sims, Donna L. Farber
Summary: This study investigated the immune responses in the respiratory tract and blood of severe COVID-19 patients, revealing that T cells in the airways showed protective profiles while myeloid cells exhibited hyperinflammatory signatures. These findings provide important insights for understanding and treating COVID-19 lung pathology.
Article
Infectious Diseases
Qianqian Tu, Xiaoyan Yu, Wei Xie, Yetao Luo, Hong Tang, Kai Chen, Yanting Ruan, Yue Li, Jie Zhou, Yibing Yin, Dapeng Chen, Zhixin Song
Summary: This study investigated the role of Prokineticin 2 (PK2) in bacterial pneumonia. The levels of PK2 were found to be decreased in patients with pneumonia compared to healthy controls, and even lower in patients with severe pneumonia. Administering recombinant PK2 in a mouse model of bacterial pneumonia alleviated lung injury, improved survival, and enhanced the host's bacterial clearance capacity. PK2 was shown to enhance the chemotaxis, phagocytosis, and killing ability of macrophages.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
John R. Bethea, Roman Fischer
Summary: Chronic neuropathic pain is caused by a lesion or disease of the somatosensory nervous system, affecting around 8% of the general population and impacting a person's quality of life negatively. Immune cells play a crucial role in the development and recovery of CNP, making them attractive targets for novel pain therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Guoxing Tang, Shutao Tong, Xu Yuan, Qun Lin, Ying Luo, Huijuan Song, Wei Liu, Shiji Wu, Liyan Mao, Weiyong Liu, Yaowu Zhu, Ziyong Sun, Feng Wang
Summary: Pneumocystis jiroveci pneumonia (PJP) is a common opportunistic infection in immunocompromised patients. This study found that a model based on a combination of routine laboratory and immunological indicators has significant value in predicting the development of PJP in HIV-negative patients undergoing immunosuppressive therapy. The combination of CD8(+) T cells and LDH proved to be particularly effective in distinguishing PJP from non-PJP patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rumen Harizanov, Nina Tsvetkova, Aleksandra Ivanova, Raina Enikova, Mihaela Videnova, Iskra Rainova, Eleonora Kaneva, Iskren Kaftandjiev, Dimitar Strashimirov, Nina Yancheva-Petrova, Ivan Simeonovski, Viktoria Levterova, Nikolay Yanev
Summary: This study aimed to establish the prevalence of Pneumocystis jirovecii infection in human hosts with different immune status and compare it with classical staining methods. The results showed that real-time PCR had higher sensitivity than staining methods, and the choice of a method for sample collection and examination played an important role in the efficiency of the laboratory diagnostics.
Review
Cell Biology
Sonia Cabeza-Fernandez, Jessica A. White, Christopher E. McMurran, Jose A. Gomez-Sanchez, Alerie G. de la Fuente
Summary: The interaction between immune and stem cells is crucial for tissue homeostasis and regeneration. Recently, it has been discovered that oligodendrocyte progenitor cells (OPCs), a type of brain stem cell, engage in bidirectional interactions with the immune system. Understanding this interaction holds great potential for developing new therapeutic approaches to limit neuroinflammation and promote myelin repair, which are important features in neurodegenerative diseases.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Meeting Abstract
Substance Abuse
D. R. Samuelson, R. W. Siggins, S. Ruan, A. M. Amedee, J. E. Shellito, D. A. Welsh
Article
Substance Abuse
Derrick R. Samuelson, Robert W. Siggins, Sanbao Ruan, Angela M. Amedee, Jiusong Sun, Quan Karen Zhu, Wayne A. Marasco, Christopher M. Taylor, Meng Luo, David A. Welsh, Judd E. Shellito
Article
Substance Abuse
Derrick R. Samuelson, Min Gu, Judd E. Shellito, Patricia E. Molina, Christopher M. Taylor, Meng Luo, David A. Welsh
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Martin J. Ronis, Kelly E. Mercer, Kartik Shankar, Casey Pulliam, Kim Pedersen, Magnus Ingelman-Sundberg, Simonetta Friso, Derrick Samuelson, Luis Del Valle, Chris Taylor, David A. Welsh
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Substance Abuse
Kristina L. Bailey, Derrick R. Samuelson, Todd A. Wyatt
Summary: Alcohol misuse has long been recognized as a factor in the pathophysiology of lung diseases, affecting susceptibility to infections and lung barrier function. This suggests that alcohol-related lung issues could contribute to both the susceptibility and severity of COVID-19 infections.
Article
Biodiversity Conservation
Mystera M. Samuelson, Eric E. Pulis, Candis Ray, Covadonga R. Arias, Derrick R. Samuelson, Erin E. Mattson, Moby Solangi
ENDANGERED SPECIES RESEARCH
(2020)
Article
Substance Abuse
Min Gu, Derrick R. Samuelson, Christopher M. Taylor, Patricia E. Molina, Meng Luo, Robert W. Siggins, Judd E. Shellito, David A. Welsh
Summary: Chronic alcohol consumption leads to a decrease in MAIT cells in barrier tissues, while CD69 expression on tissue-associated MAIT cells is increased in alcohol-fed (AF) mice. Th1 cytokines show tissue-specific expression changes in AF animals. Transplantation of fecal microbiota from AF mice results in a MAIT cell profile aligned to that of AF mouse donor, and antibiotic treatment abolishes the differences in MAIT cells between AF and pair-fed (PF) animals.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Immunology
Sannette C. Hall, Deandra R. Smith, Shetty Ravi Dyavar, Todd A. Wyatt, Derrick R. Samuelson, Kristina L. Bailey, Daren L. Knoell
Summary: Zinc is essential for immune function and host defense, regulated by zinc transporters. Zinc deficiency can increase susceptibility to bacterial infections, especially Streptococcus pneumoniae. Myeloid cells, such as macrophages and dendritic cells, play a critical role in shaping the immune response in the lung against bacterial pathogens.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biology
Derrick R. Samuelson, Min Gu, Judd E. Shellito, Patricia E. Molina, Christopher M. Taylor, Meng Luo, David A. Welsh
Summary: Alcohol impairs immune function and cellular transport, increasing susceptibility to bacterial pneumonia. Microbial metabolites can mitigate alcohol-induced risks, partially through AhR. Microbiota therapeutics are effective in reducing the risk of alcohol-associated bacterial pneumonia.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell
Summary: Pneumococcal pneumonia is a major cause of disease and death worldwide, with compromised immune function and an insufficient dietary intake of zinc increasing the risk. This study reveals the critical role of the zinc transporter ZIP8 in host defense and the adverse impact of a common defective ZIP8 allele on the gut microbiota essential for lung immunity. Loss of ZIP8 function leads to intestinal dysbiosis and impaired host defense in the lung, highlighting the need for further investigation and improved surveillance and treatment strategies given the high incidence of dietary zinc deficiency and the ZIP8 variant allele in the human population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vineet Joshi, Yashpal S. Chhonker, Dhruvkumar Soni, Kelly C. Cunningham, Derrick R. Samuelson, Daryl J. Murry
Summary: A novel LC-MS/MS method was developed to quantify indole concentrations in mouse plasma and tissues, which could serve as a biomarker for several diseases. This method separated and measured the ion state of indole and an internal standard, allowing for accurate determination of indole concentrations range in different samples. This study contributes to the understanding of the role of indole as a biomarker and its implications in various disease states.
Review
Substance Abuse
Kathryn Crotty, Paige Anton, Leon G. Coleman, Niya L. Morris, Sloan A. Lewis, Derrick R. Samuelson, Rachel H. McMahan, Phillipp Hartmann, Adam Kim, Anuradha Ratna, Pranoti Mandrekar, Todd A. Wyatt, Mashkoor A. Choudhry, Elizabeth J. Kovacs, Rebecca McCullough, Samantha M. Yeligar
Summary: This critical review describes the potential mechanisms by which alcohol misuse leads to immune system dysfunction and highlights the current research gaps.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Microbiology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Sabah Haq, Daniel N. Villageliu, Christi M. Ellis, Niaz Bahar Chowdhury, Amanda E. Ramer-Tait, Jeffrey D. Price, Daren L. Knoell
Summary: Intestinal dysbiosis increases susceptibility to infection due to metabolic profile changes, resulting in increased morbidity. The study found that ZIP8, a type of zinc transporter, is important for myeloid cells in maintaining host defense against bacterial pneumonia. Furthermore, a common variant of ZIP8 is closely associated with inflammation-based disorders and bacterial infection. The researchers developed a new model to study the effects of ZIP8-mediated intestinal dysbiosis on pulmonary host defense, independent of genetic factors. The results showed that the intestinal microbiota, regardless of host genetics, play a crucial role in regulating host defense in the lung against infection. These findings support future microbiome-based intervention studies, considering the high prevalence of zinc deficiency and the rs13107325 allele in humans.
Article
Cell Biology
Kelly C. Cunningham, Deandra R. Smith, Daniel N. Villageliu, Christi M. Ellis, Amanda E. Ramer-Tait, Jeffrey D. Price, Todd A. Wyatt, Daren L. Knoell, Mystera M. Samuelson, Patricia E. Molina, David A. Welsh, Derrick R. Samuelson
Summary: Chronic alcohol abuse leads to alterations in the gastrointestinal microbiota, resulting in behavior changes, physiological alterations, and immunological effects. This study developed a humanized alcohol-microbiota mouse model and found that colonization of mice with fecal microbiota from individuals with high AUDIT scores increased susceptibility to pneumonia.
Meeting Abstract
Substance Abuse
D. R. Samuelson, R. W. Siggins, J. E. Shellito, C. M. Taylor, P. E. Molina, D. A. Welsh
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)