Article
Allergy
Cristiane Kayser, Livia Almeida Dutra, Edgard Torres dos Reis-Neto, Charlles Heldan de Moura Castro, Marvin J. Fritzler, Luis Eduardo C. Andrade
Summary: Personalized medicine aims to individualize prevention, diagnosis, and treatment. Autoantibodies play a crucial role in the personalized medicine of autoimmune diseases.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Bryan Ju Min Yap, Ashley Sean Lai-Foenander, Bey Hing Goh, Yong Sze Ong, Acharaporn Duangjai, Surasak Saokaew, Caroline Lin Lin Chua, Pochamana Phisalprapa, Wei Hsum Yap
Summary: Leukocytoclastic vasculitis is characterized by inflammation of the vascular endothelium, with advancements in genomic technologies helping to identify genetic variations and pathways for targeted therapies. Personalized medicine aims to provide more effective treatments for individuals through understanding immunopathogenic pathways and genetic associations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Engineering, Biomedical
Ian M. Tayler, Ryan S. Stowers
Summary: Technological innovations and scientific advances have led to the era of personalized medicine, where the use of hydrogels for creating artificial cellular microenvironments is crucial for applications in personalized tissue engineering, regenerative medicine, and disease modeling. Engineering strategies to control stem cell fate, in combination with advanced imaging methods and novel bioprinting techniques, contribute to the development of functional tissues and personalized disease models. The continued progress in hydrogel development, along with other emerging technologies, is essential to realize the immense potential of personalized medicine.
ACTA BIOMATERIALIA
(2021)
Article
Immunology
Manuel Rojas, Carolina Ramirez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Monica Rodriguez-Jimenez, Elizabeth Zapata, Angie Naranjo-Pulido, Ana Suarez-Avellaneda, Lady J. Rios-Serna, Carolina Prieto, William Zambrano-Romero, Maria Alejandra Valero, Yhojan Rodriguez, Ruben D. Mantilla, Chengsong Zhu, Quan-Zhen Li, Carlos Enrique Toro-Gutierrez, Gabriel J. Tobon, Juan-Manuel Anaya
Summary: This study explored a new taxonomy of ADs based on PolyA, finding that latent PolyA is more common than overt PolyA. The combination of autoantibodies allows high accuracy in the classification of ADs, and three distinct clusters based on PolyA were observed with unique clinical and immunological phenotypes.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Endocrinology & Metabolism
C. Betterle, J. Furmaniak, C. Sabbadin, C. Scaroni, F. Presotto
Summary: The number of autoimmune diseases (AIDs) has increased and they often co-occur in a single patient, with autoimmune thyroid diseases (AITD) being the most prevalent. AITD can be viewed as the center of autoimmunity, with other AIDs gravitating around it like satellites.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Immunology
Anne-Marie Aubin, Felix Lombard-Vadnais, Roxanne Collin, Holly A. Aliesky, Sandra M. McLachlan, Sylvie Lesage
Summary: NOD mice are an important model for studying autoimmune diseases, with characteristics of multiple autoimmune diseases in addition to diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Danielle J. Beetler, Damian N. Di Florio, Katelyn A. Bruno, Tsuneya Ikezu, Keith L. March, Leslie T. Cooper Jr., Joy Wolfram, DeLisa Fairweather
Summary: Extracellular vesicles (EVs) are an important intercellular communication network released from all cells in the body, contributing to both health and disease. The specificity of EVs and their accumulation in accessible fluid spaces make them potential biomarkers and therapies for various diseases. This review discusses their use in biomarker identification, drug delivery, and regenerative medicine, highlighting their relevance in viral infections, cancer, and neurological diseases. EV biomarkers and therapeutic approaches show promise for personalized medicine due to their diversity and multifunctionality.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Dory Rotnemer-Golinkin, Yaron Ilan
Summary: This feasibility study established a model to determine the personalized-inherent variability in a time-dependent response to immune triggers. The results demonstrate significant inter- and intrasubject variations in the timing and magnitude of immune response to triggers. These findings emphasize the importance of considering individualized time-dependent variability in immune responses when designing personalized-based immunotherapies.
Article
Biochemical Research Methods
Daniel Toro-Dominguez, Jordi Martorell-Marugan, Manuel Martinez-Bueno, Raul Lopez-Dominguez, Elena Carnero-Montoro, Guillermo Barturen, Daniel Goldman, Michelle Petri, Pedro Carmona-Saez, Marta E. Alarcon-Riquelme
Summary: This study developed MyPROSLE, an omic-based analytical workflow, to measure the molecular characteristics of individual patients and support therapeutic decisions. Through analysis of nearly 6100 lupus patients and 750 healthy samples, it was found that dysregulation of certain gene-modules is strongly associated with specific clinical manifestations, relapses, long-term remission, and drug response. Therefore, MyPROSLE can accurately predict these clinical outcomes.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Health Care Sciences & Services
Mohammad Dehestani, Hui Liu, Thomas Gasser
Summary: Parkinson's disease is a neurodegenerative disorder involving the loss of dopaminergic neurons. The disease is believed to be caused by a combination of polygenic and environmental factors. Polygenic risk scores can be a useful predictive tool in identifying high-risk patients, although there are limitations to its construction and application.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Sara Green, Annamaria Carusi, Klaus Hoeyer
Summary: Politically authorized reports emphasize the urgent need for finer-grained disease categories and faster taxonomic revision in personalized and precision medicine. However, developing a data-driven taxonomy is not as simple as it seems. Analysis of the Danish National Genome Center initiatives reveals challenges in implementing integrated data infrastructure in centralized and digitalized healthcare systems. The study discusses the epistemic and organizational implications of a genomics-based disease taxonomy, highlighting tensions between variation and standardization in medicine and concerns about regulatory shifts in evidence standards.
SOCIAL SCIENCE & MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Alfredo Cesario, Marika D'Oria, Irene Simone, Stefano Patarnello, Vincenzo Valentini, Giovanni Scambia
Summary: Personalized medicine utilizes digital and technological solutions to drive innovation and generate new knowledge, while the open innovation paradigm effectively manages transformation in healthcare organizations. This article examines the transition from personalized medicine to personalized digital medicine in a large research hospital, discussing methods, challenges, and results.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Medicinal
Ki-Uk Kim, Jisu Kim, Wan-Hoon Kim, Hyeyoung Min, Chang Hwan Choi
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease treated with various medications and biologic agents. However, some patients develop resistance or lose response to biologic agents, leading to ongoing research on predictive factors for treatment outcomes.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Yuichi Yamamoto, Norihiro Kanayama, Yusuke Nakayama, Nobuko Matsushima
Summary: In recent years, personalized medicine has made significant progress in the fields of cancer and rare diseases. However, there is still a need for further research and development in other disease areas such as rheumatoid arthritis, psoriasis, and Alzheimer's disease. These diseases have high unmet needs for personalized medicine, including understanding disease mechanisms, developing diagnostic methods, and finding new therapeutic drugs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Manuel Rojas, Carolina Ramirez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Monica Rodriguez-Jimenez, Elizabeth Zapata, Angie Naranjo-Pulido, Ana Suarez-Avellaneda, Lady J. Rios-Serna, Carolina Prieto, William Zambrano-Romero, Maria Alejandra Valero, Yhojan Rodriguez, Ruben D. Mantilla, Chengsong Zhu, Quan-Zhen Li, Carlos Enrique Toro-Gutierrez, Gabriel J. Tobon, Juan-Manuel Anaya
Summary: This study explored a new taxonomy of ADs based on PolyA, finding that latent PolyA is more common than overt PolyA. The combination of autoantibodies allows high accuracy in the classification of ADs, and three distinct clusters based on PolyA were observed with unique clinical and immunological phenotypes.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Yeny Acosta-Ampudia, Diana M. Monsalve, Manuel Rojas, Yhojan Rodriguez, Elizabeth Zapata, Carolina Ramirez-Santana, Juan-Manuel Anaya
Summary: Post-COVID syndrome is characterized by the persistence of latent autoimmunity up to 11 months after recovery, accompanied by a persistent proinflammatory state and altered effector phenotype. The need to evaluate the role of immunomodulation in the treatment of PCS is suggested.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Immunology
Yeny Acosta-Ampudia, Juan-Manuel Anaya
JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Medicine, Research & Experimental
Manuel Rojas, Yhojan Rodriguez, Yeny Acosta-Ampudia, Diana M. Monsalve, Chengsong Zhu, Quan-Zhen Li, Carolina Ramirez-Santana, Juan-Manuel Anaya
Summary: Autoimmunity is a characteristic of post-COVID syndrome (PCS), and it is correlated with the humoral response to SARS-CoV-2.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jeremy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jeremie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martinez, Rui Yang, Liis Haljasmagi, Melanie Migaud, Karita Sarekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesus Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garcon, Jacques G. Riviere, Jean-Christophe Lagier, Stephanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre-Louis Tharaux, Damien Sene, Alain Stepanian, Bruno Megarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, Jose Luis Franco, Juan-Manuel Anaya, Jordi Sole-Violan, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada-Velez, Andres Augusto Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Ahmed A. Bousfiha, Jalila El Bakkouri, Carolina Ramirez-Santana, Stephane Paul, Qiang Pan-Hammarstrom, Lennart Hammarstrom, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila A. Barreiros, Elena Dominguez-Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yurii Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, Yu-Lung Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angelique Chauvineau-Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris-Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Sean Kennelly, Nollaig M. Bourkeh, Rabih Halwan, Fatemeh Saheb Sharif-Askar, Karim Dorgham, Jerome Sallette, Souad Mehlal Sedkaoui, Suzan AlKhater, Raul Rigo-Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antonio Condino-Neto, Carolina Prando, Anastasiia Bondarenko, Andras N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilguvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Beziat, Shen-Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Part Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stephanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler-Palacin, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martinez-Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodriguez-Gallego, Luigi D Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean-Laurent Casanova, Laurent Abel, Aurelie Cobat
Summary: This study investigates the impact of autoimmunity on COVID-19-related deaths and finds that individuals carrying autoantibodies neutralizing type I interferons are at higher risk of death, with the risk decreasing with age.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin V. Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam A. Adler, Ilias Alevizos, Juan-Manuel G. Anaya, Lara Aqrawi, Eva Baecklund, Johan Brun, Sara Magnusson Bucher, Maija-Leena B. Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart Glenn, Daniel Hammenfors, Juliana V. Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend A. Johnsen, Malin Jonsson, Marika Kvarnstroem, Jennifer Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke M. Norheim, Oyvind E. Palm, Kathrine Skarstein, Anna Stolarczyk, Kimberly Taylor, Maria J. Teruel, Elke M. Theander, Swamy S. Venuturupalli, Daniel Wallace, Kiely M. Grundahl, Kimberly U. Hefner, Lida Radfar, David T. Lewis, Donald M. Stone, C. Erick A. Kaufman, Michael Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick Gaffney, Lindsey J. Criswell, Roland Jonsson, Per Eriksson, Simon Bowman, Roald Omdal, Lars Roennblom, Blake Warner, Maureen Rischmueller, Torsten E. Witte, A. Darise H. Farris, Xavier Mariette, Marta Alarcon-Riquelme, Caroline L. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy J. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher Lessard
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Alexander J. Davies, Cinta Lleixa, Ana M. Siles, Dawn S. Gourlay, Georgina Berridge, Wanwisa Dejnirattisai, Carolina Ramirez-Santana, Juan-Manuel Anaya, Andrew K. Falconar, Claudia M. Romero-Vivas, Lyda Osorio, Beatriz Parra, Gavin R. Screaton, Juthathip Mongkolsapaya, Roman Fischer, Carlos A. Pardo, Susan K. Halstead, Hugh J. Willison, Luis Querol, Simon Rinaldi
Summary: By screening the sera of patients with Zika virus (ZIKV) with and without Guillain-Barre syndrome (GBS), researchers discovered the presence of autoantibodies targeting peripheral nerves. This suggests that Zika virus infection may lead to immune-mediated neurologic symptoms.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Immunology
Pedro Santos-Moreno, Julian Arias-Aponte, Gabriel-Santiago Rodriguez-Vargas, Paula Daniela Nieto-Zambrano, Laura Villarreal, Linda Ibata, Susan Martinez, Jaime-Andres Rubio-Rubio, Pedro Rodriguez, Adriana Rojas-Villarraga
Summary: This study aimed to assess the frequency and associated factors of polyautoimmunity (PolyA) in Colombian patients with systemic lupus erythematosus (SLE). The results identified age, xerophthalmia, central nervous system occlusion, and deep vein thrombosis as factors associated with PolyA. Renal impairment was significantly less frequent in PolyA patients.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Review
Virology
Ruediger E. Scharf, Juan-Manuel Anaya
Summary: This article provides an overview of various aspects related to post-COVID syndrome, including its prevalence, symptoms and sequelae, risk determinants, and psychosocial implications. It also discusses the pathogenesis of post-COVID condition, focusing on thrombo-inflammation, neutrophil extracellular traps, and venous thromboembolism. Additionally, it reviews COVID-19 and post-COVID syndrome in immunocompromising conditions, and the impact of vaccination on the prevention and treatment of post-COVID symptoms. The article highlights autoimmunity as a hallmark of post-COVID syndrome and the potential increase of autoimmune disorders globally.
Meeting Abstract
Critical Care Medicine
L. Acevedo, B. E. Pineres, L. F. Nino, L. Mazzillo, I. J. Ardila, S. Chacon, J. C. Jaramillo, H. Mulett, O. Gonzalez, E. Zemanate, L. Izquierdo, J. Rojas, J. Piracoca, J. L. Junco, B. Giraldo, C. Bonilla, H. Preciado, R. Orozco, M. Alvarez, C. Giraldo, J. C. Salazar, J. M. Anaya
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Review
Immunology
Laura Camacho-Dominguez, Yhojan Rodriguez, Fernando Polo, Juan Carlos Restrepo Gutierrez, Elizabeth Zapata, Manuel Rojas, Juan-Manuel Anaya
Summary: This report presents a case of a 79-year-old man who developed autoimmune hepatitis type 1 after receiving the ChAdOx1 nCoV-19 vaccine. Clinical symptoms improved rapidly after immunomodulatory treatment was initiated. This case, along with a comprehensive literature review, highlights the association between COVID-19 vaccines and the development of autoimmune conditions.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)