Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse

Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues

(2015) Bernard Malissen et al.   Annual Review of Immunology

A Dynamic Model of Chemoattractant-Induced Cell Migration

(2015) Hao Yang et al.   BIOPHYSICAL JOURNAL

Human Primary Immune Cells Exhibit Distinct Mechanical Properties that Are Modified by Inflammation

(2015) Nathalie Bufi et al.   BIOPHYSICAL JOURNAL

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

(2015) Erdem Tabdanov et al.   Integrative Biology

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration

(2015) A. Schaefer et al.   JOURNAL OF CELL SCIENCE

Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells

(2015) Jinsung Hong et al.   JOURNAL OF IMMUNOLOGY

Cytoskeletal forces during signaling activation in Jurkat T-cells

(2015) King Lam Hui et al.   MOLECULAR BIOLOGY OF THE CELL

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

(2015) Hélène D. Moreau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Ligand-Mediated Friction Determines Morphodynamics of Spreading T Cells

(2014) Pierre Dillard et al.   BIOPHYSICAL JOURNAL

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm

(2014) Peter Beemiller et al.   IMMUNOLOGICAL REVIEWS

The actin-driven spatiotemporal organization of T-cell signaling at the system scale

(2014) Kole T. Roybal et al.   IMMUNOLOGICAL REVIEWS

Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation

(2014) Alexander Babich et al.   IMMUNOLOGICAL REVIEWS

Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance

(2014) R. Martinelli et al.   JOURNAL OF CELL SCIENCE

Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells

(2014) S. Pryshchep et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells control fibroblastic reticular network tension and lymph node expansion

(2014) Sophie E. Acton et al.   NATURE

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

(2014) Kaushik Choudhuri et al.   NATURE

The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture

(2014) Jillian L Astarita et al.   NATURE IMMUNOLOGY

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical Cues and Cell Behavior: The Big Impact of Little Things

(2013) Joshua Z. Gasiorowski et al.   Annual Review of Biomedical Engineering

T cell antigen receptor activation and actin cytoskeleton remodeling

(2013) Sudha Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Heart-Specific Stiffening in Early Embryos Parallels Matrix and Myosin Expression to Optimize Beating

(2013) Stephanie Majkut et al.   CURRENT BIOLOGY

Guiding cell migration by tugging

(2013) Sergey V Plotnikov et al.   CURRENT OPINION IN CELL BIOLOGY

Controversy and consensus regarding myosin II function at the immunological synapse

(2013) John A Hammer et al.   CURRENT OPINION IN IMMUNOLOGY

Visualizing how T cells collect activation signals in vivo

(2013) Hélène D Moreau et al.   CURRENT OPINION IN IMMUNOLOGY

Activation of beta 1 but not beta 3 integrin increases cell traction forces

(2013) Grace L. Lin et al.   FEBS LETTERS

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

Cross Talk between CD3 and CD28 Is Spatially Modulated by Protein Lateral Mobility

(2013) K. T. Bashour et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions

(2013) Fang Kong et al.   MOLECULAR CELL

The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

(2013) Yinming Liang et al.   NATURE IMMUNOLOGY

Membrane Tension, Myosin Force, and Actin Turnover Maintain Actin Treadmill in the Nerve Growth Cone

(2012) Erin M. Craig et al.   BIOPHYSICAL JOURNAL

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Dynamic In Situ Cytometry Uncovers T Cell Receptor Signaling during Immunological Synapses and Kinapses In Vivo

(2012) Hélène D. Moreau et al.   IMMUNITY

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function

(2012) Jia-huai Wang et al.   IMMUNOLOGICAL REVIEWS

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction

(2012) Ulrich S. Schwarz et al.   JOURNAL OF CELL SCIENCE

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

(2012) P. T. Sage et al.   JOURNAL OF IMMUNOLOGY

Cytokine Secretion by CD4+ T Cells at the Immunological Synapse Requires Cdc42-Dependent Local Actin Remodeling but Not Microtubule Organizing Center Polarity

(2012) K. Chemin et al.   JOURNAL OF IMMUNOLOGY

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Cell Elasticity Determines Macrophage Function

(2012) Naimish R. Patel et al.   PLoS One

Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent

(2012) Andrew E. Ekpenyong et al.   PLoS One

Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

(2012) L. Pace et al.   SCIENCE

Membrane dynamics shape TCR-generated signaling

(2012) Hai-Tao He et al.   Frontiers in Immunology

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

(2012) Sudha Kumari et al.   Frontiers in Immunology

Traction Forces of Neutrophils Migrating on Compliant Substrates

(2011) Risat A. Jannat et al.   BIOPHYSICAL JOURNAL

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

(2011) G. Bouma et al.   BLOOD

Mechanical Interactions between Dendritic Cells and T Cells Correlate with T Cell Responsiveness

(2011) T. S. Lim et al.   JOURNAL OF IMMUNOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immunological synapse: a focal point for endocytosis and exocytosis

(2010) Gillian M. Griffiths et al.   JOURNAL OF CELL BIOLOGY

Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of    T Cell Receptors

(2010) S. T. Kim et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Probing Cellular Traction Forces by Micropillar Arrays: Contribution of Substrate Warping to Pillar Deflection

(2010) Ingmar Schoen et al.   NANO LETTERS

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Spatial organization and signal transduction at intercellular junctions

(2010) Boryana N. Manz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses

(2010) Cheng-han Yu et al.   PLoS One

Neutrophil morphology and migration are affected by substrate elasticity

(2009) P. W. Oakes et al.   BLOOD

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

(2009) A. Gerard et al.   BLOOD

The mechanical cell

(2009) Shang-You Tee et al.   CURRENT BIOLOGY

Endocytic events in TCR signaling: focus on adapters in microclusters

(2009) Lakshmi Balagopalan et al.   IMMUNOLOGICAL REVIEWS

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions'

(2009) C. V. Carman   JOURNAL OF CELL SCIENCE

Cluster size regulates protein sorting in the immunological synapse

(2009) N. C. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy

(2009) B. H. Hosseini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulatory role of cell mechanics for migration of differentiating myeloid cells

(2009) F. Lautenschlager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do membrane undulations help cells probe the world?

(2009) Anne Pierres et al.   TRENDS IN CELL BIOLOGY

The Actin Cytoskeleton in T Cell Activation

(2008) Janis K. Burkhardt et al.   Annual Review of Immunology

The Stochastic Dynamics of Filopodial Growth

(2008) Yueheng Lan et al.   BIOPHYSICAL JOURNAL

T Cell Receptor Microcluster Transport through Molecular Mazes Reveals Mechanism of Translocation

(2008) Andrew L. DeMond et al.   BIOPHYSICAL JOURNAL

Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering

(2008) P. J. Fisher et al.   BLOOD

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The receptor deformation model of TCR triggering

(2007) Zhengyu Ma et al.   FASEB JOURNAL