期刊
EJNMMI RESEARCH
卷 6, 期 -, 页码 -出版社
SPRINGEROPEN
DOI: 10.1186/s13550-016-0177-8
关键词
[F-18]FDG uptake; SUVpeak; Acquisition time
Background: This study is an assessment of the impact of acquisition times on SUV with [F-18]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors. Methods: One hundred six [F-18]FDG-PET/CT were acquired in list mode over a single-bed position (livers (n = 48) or on tumors (n = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUVmax (hottest voxel), SUVpeak (maximum average SUV within a 1-cm(3) spherical volume), and SUVaverage were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [F-18]FDG avid tumors (SUVmax >= 5), the SUVmax, SUVpeak, and SUV41% (isocontour threshold method) were computed. Results: For tumors, SUVpeak values did not vary with acquisition time. SUVmax displayed significant differences between 1.5- and 5-10-min reconstruction times. SUV41% was the most time-dependent parameter. For the liver, the SUVaverage was the sole parameter that did not vary over time. Conclusions: For [F-18]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUVpeak may be more robust than the SUVmax. The SUVaverage over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.
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