Article
Optics
Cong Li, Jun Huang, Meng Zhang, Yuxin Chen, Tingting Liu, Kehong Wang
Summary: Laser assisted suture research has gained attention for its advantages, but there is a need for deeper investigation. This study explored the impact of external restraint force on laser tissue welding, analyzing its effect on the optical properties of skin tissue. Using a Nd:YAG pulse laser, experiments on skin incisions demonstrated improved absorption and suture strength under compression force. Results showed that external preloading force significantly affected tissue strength, and different forces altered the absorption rate and thickness for improved welding strength.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Gerard Boix-Lemonche, Richard M. Nagymihaly, Essi M. Niemi, Natasha Josifovska, Stian Johansen, Morten C. Moe, Hanne Scholz, Goran Petrovski
Summary: Injury of the cornea is a complex biological process that can be facilitated by mesenchymal stromal cells (MSCs) and tissue equivalents. This study presents a new tissue-engineering strategy for corneal stroma regeneration using cellularized 3D bioprinted hydrogel constructs implanted into cultured porcine corneas. The experiment successfully combines laboratory-based methods with patient-care practice to produce a cell-laden tissue equivalent for corneal implantation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Chemical
Michael Wolf, Dietmar Drummer
Summary: Laser-sintering technology enables cost-effective production of complex and individualized components, while welding is essential for exploiting the advantages of laser-sintering in assemblies with mass-produced components. Low weld pressure can lead to high strength joints in PA12 laser-sintered and injection-molded parts.
POLYMER ENGINEERING AND SCIENCE
(2021)
Article
Engineering, Biomedical
Kaveh Roshanbinfar, Maria Kolesnik-Gray, Miriam Angeloni, Stefan Schruefer, Maren Fiedler, Dirk W. Schubert, Fulvia Ferrazzi, Vojislav Krstic, Felix B. Engel
Summary: Cardiac tissue engineering is a promising strategy to prevent heart failure, but several issues remain unsolved. This study develops a biohybrid hydrogel that enhances the beating properties of engineered cardiac tissues and allows for concurrent drug release.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Acoustics
Christian Nowroth, Jan Grajczak, Andreas Schmelt, Sarah Nothdurft, Jens Twiefel, Joerg Hermsdorf, Stefan Kaierle, Joerg Wallaschek
Summary: New strategies are required in modern process chains to meet the constantly increasing demands on components and their resource-efficient production. The Collaborative Research Centre (CRC) 1153 "Tailored Forming" is investigating the production of hybrid solid components made from joined semi-finished products. Laser beam welding with ultrasonic assistance has proven to be advantageous in the production of semi-finished products due to its active influence on the microstructure. This study explores the feasibility of extending the monofrequency excitation of the melt pool used in welding to a multifrequency excitation, and the results show that it can be effectively realized.
Article
Optics
Tatiana O. Lipateva, Andrey G. Okhrimchuk, Alexey S. Lipatiev, Igor A. Karateev, Sergey S. Fedotov, Sergey V. Lotarev, Alexander V. Shestakov, Vladimir N. Sigaev
Summary: The laser-assisted yttrium aluminum garnet (YAG) crystal-to-crystal bonding with shear strength up to 110 MPa was investigated using various microscopy techniques. The presence of an amorphous phase, confirmed by electron microscopy, showed a nanoperiodic amorphous nanoplanes structure interleaved with crystalline regions. The results suggest a potential development of passive cooling technology for high-power solid-state lasers.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Optics
Cong Li, Kehong Wang, Jun Huang, Jikang Fan
Summary: Research has shown that adding indocyanine green flux can significantly enhance the strength of laser tissue welding, with better results when applied on the front side. Indocyanine green and methylene blue are significant organic chromophores in the laser welding process, promoting photo-thermal conversion efficiency, improving welding strength, and reducing thermal damage.
Article
Metallurgy & Metallurgical Engineering
Klaus Schricker, Jean Pierre Bergmann, Marcus Hopfeld, Lothar Spiess
Summary: This study investigated the mechanical properties of the joint between semi-crystalline polyamide 6 and aluminum EN AW 6082 in laser-based joining, finding that an increase in energy per unit length led to reduced crosshead displacement and decreased fatigue strength in short-term testing. Further material testing and analysis revealed that heat treatment was identified as a primary factor causing changes in mechanical properties of the thermoplastic material.
WELDING IN THE WORLD
(2021)
Article
Automation & Control Systems
Zheng-tian Wang, Zhen-yu Xiong, Shu-yuan Jiang, Yi-ping Chen, De-an Hu, Dong-hai Cheng
Summary: Magnetic field-assisted welding plays a significant role in improving weld bead properties. This study conducted a full-factor experiment and built a numerical simulation model to investigate the mechanism of magnetic field influence on the dissimilar laser wire feed weld brazing profile of aluminium and copper. The results showed that increasing the magnetic flux density significantly improved the properties of the weld bead, including wetting angle, fluid flow direction, and intermetallic compounds. The computed and measured distortions also demonstrated good agreement in the fusion zone.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2022)
Article
Optics
Yuxin Chen, Jun Huang, Shengnan Xia, Kehong Wang, Yunfeng Rui
Summary: In this study, the researchers investigated the effect of laser defocus amount on the macroscopic mechanical properties, microstructure characteristics, and thermal damage of skin tissue. They found that the change in defocus amount directly influenced the laser focusing radius and laser power density, subsequently affecting the fusion performance of skin tissue. By conducting laser welding experiments with different defocus values, the researchers measured and analyzed the mechanical properties and microstructure of the samples, and calculated the collagen content and thermal damage. The results showed that the fusion performance of skin tissue varied with the defocus amount, with the best performance observed at -1 mm defocus, which had the highest collagen content, superior microstructure homogenization, and the highest tensile strength (32.47 N/cm2).
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Kermit K. Murray
Summary: MALDI, introduced 35 years ago, has evolved from producing intact ions from large biomolecules to wide use in applications such as bacteria identification and tissue imaging, enabled by high energy pulsed lasers. Various laser sources with different wavelengths and pulse widths have been introduced for MALDI, including wavelength tunable sources and dual-pulse configurations for ionization in mass spectrometry.
JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Metallurgy & Metallurgical Engineering
Tao Tao, Jin-shui Liu, Dian-wu Zhou, Hui-ming LI, Xin-yu Wang
Summary: The experiments involved laser welding of AZ31B magnesium alloy and DP590 dual-phase steel with interlayer addition in an overlap magnesium-on-steel configuration. The interlayer elements were selected based on thermodynamic properties and intrinsic mechanical properties, and the resulting changes in microstructure and properties of the magnesium/steel joint were analyzed. The addition of Sn and Al interlayers increased the maximum load of the joint to 730 and 590 N, respectively, which were 2.04 times and 1.46 times higher than without interlayer. The formation of brittle Mg17Al12 compound at the magnesium/steel interface limited the mechanical performance improvement of the joint with Al interlayer, while the formation of relatively low brittleness Mg2Sn and ductile Fe3Sn at the magnesium/steel interface contributed to the higher properties of the joint with Sn interlayer.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2023)
Article
Biochemical Research Methods
Mengshi Jia, Jun Huang, Yuxin Chen, Jincheng Li, Kehong Wang
Summary: This experiment analyzed the influence of nine scanning paths on the surface morphology, degree of thermal damage, tensile strength, and microstructure of skin samples after welding. The results showed that the interrupted parallel mattress eversion sewing method with d = 0.2 mm resulted in no obvious color changes, high tensile strength of 12.80 N/cm(2), low thermal damage parameter of 1.08 x 10(-2), and clear and uniformly distributed microstructure.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Chemistry, Multidisciplinary
Oktawian Bialas, Tomasz Poloczek, Mateusz Lis, Adam Skowronek, Jacek Gorka, Marcin Adamiak
Summary: This study aims to enrich the surface layer of titanium with gold nanoparticles by picosecond laser treatment, potentially reducing inflammation and infections post-surgery. Evaluation of gold nanoparticles and titanium micromachining showed promising characteristics for future research and material property analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Dong Wang, Yongjia Zheng, Wei Dai, Ding Tang, Yinghong Peng
Summary: This paper proposes a quality inspection framework based on a two-branch network and conventional image processing to predict welding quality and output corresponding parameter information. Experimental results demonstrate that the proposed model achieves significant classification performance on an actual production line.
Article
Chemistry, Multidisciplinary
Wei Wang, Zhiguang Wu, Ling Yang, Tieyan Si, Qiang He
Summary: In this study, bio-inspired polyelectrolyte multilayer conical nanoswimmers with gold-nanoshell functionalization on different segments were designed using bottom-up controllable molecular assembly. The presence of gold nanoshells on the big openings of the nanoswimmers not only provided efficient directional propulsion but also minimized the impact from the external flow. The experiment demonstrated that the nanoswimmers with gold nanoshells could achieve acoustically powered propulsion against a flow velocity of up to 2.00 mm/s, which is higher than the blood velocity in capillaries, thus proving the concept of upstream nanoswimmers.
Article
Chemistry, Physical
Shurui Yuan, Xiankun Lin, Qiang He
Summary: The study focuses on the reconfigurable assembly of colloidal motors, which is driven and modulated by chemical reactions and external fields. It discusses the adaptive reconfiguration behaviors and mechanisms, aiming to develop interactive soft matter materials and systems with adaptation and interactive functions comparable to natural systems in the future.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Lin Wang, Sven Rutkowski, Tieyan Si, Tawheed Hashem, Bin Guo, Jie Xu, Anna Kozelskaya, Sergei Tverdokhlebov, Johannes Frueh
Summary: This study presents a method for creating liquid metal motors using biologically benign gallium. By laminating the motors with a biodegradable macromolecular thin film, the motors can retain their initial shape and be remotely guided using magnetic fields. The research demonstrates the technical realization and properties of this novel system, opening up new paths and potential applications.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Biophysics
Zewei Zhao, Tieyan Si, Anna I. Kozelskaya, Igor O. Akimchenko, Sergei I. Tverdokhlebov, Sven Rutkowski, Johannes Frueh
Summary: The speed and motion directionality of bubble-propelled micromotors depend on bubble lifetime, bubble formation frequency, and bubble stabilization. This study presents a fully biodegradable Janus structured micromotor driven by hydrogen bubbles. The presence and concentration of a surfactant reversibly change the micromotor's propulsion direction. Without a surfactant, the micromotor is pulled backward by bubble cavitation, while with a surfactant above the critical micelle concentration, it is pushed forward by the generated bubbles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Chang Zhou, Ling Yang, Yingjie Wu, Mingcheng Yang, Qiang He
Summary: Chemotactic colloidal motors have promising applications in the biomedical field, requiring submicrometer scale, strong chemotactic ability, and clear chemotactic mechanism.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Zhilei Sun, Igor A. Khlusov, Kirill E. Evdokimov, Maksim E. Konishchev, Oleg S. Kuzmin, Olga G. Khaziakhmatova, Vladimir V. Malashchenko, Larisa S. Litvinova, Sven Rutkowski, Johannes Frueh, Anna I. Kozelskaya, Sergei I. Tverdokhlebov
Summary: This article investigates the influence of nitrogen doping on titanium dioxide thin films used for coating metallic stents. It is found that different nitrogen doping levels affect the surface properties and cell adhesion of the films. Increasing nitrogen doping levels can enhance chondrogenic differentiation rate and have a positive effect on cell adhesion.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Physical
Qihan Zhang, Yuwei Yan, Jun Liu, Yingjie Wu, Qiang He
Summary: This feature article introduces the controllable self-assembly technology of supramolecular colloidal motors and their research progress in the fields of biomedicine and environment. The research provides new opportunities for precise fabrication of colloidal motors and explores the relationship between structure and propulsion.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Anna I. I. Kozelskaya, Sven Rutkowski, Johannes Frueh, Aleksey S. S. Gogolev, Sergei G. G. Chistyakov, Sergey V. V. Gnedenkov, Sergey L. L. Sinebryukhov, Andreas Frueh, Vladimir S. S. Egorkin, Evgeny L. L. Choynzonov, Mikhail Buldakov, Denis E. E. Kulbakin, Evgeny N. N. Bolbasov, Anton P. P. Gryaznov, Ksenia N. N. Verzunova, Margarita D. D. Apostolova, Sergei I. I. Tverdokhlebov
Summary: In this study, the micro-arc oxidation method was used to create surface-modified complex-structured titanium implant coatings, which significantly improved biocompatibility. Three different types of coatings were obtained by adjusting the electrolyte solution and process parameters, showing variations in coating thickness and composition that affected their biocompatibility. X-ray computed tomography was employed to analyze the structural uniformity of the coatings. Electrochemical studies demonstrated varying levels of corrosion protection provided by the coatings. In vitro and in vivo experiments confirmed high biocompatibility of the micro-arc oxidation coatings towards adult stem cells, as well as in vivo biocompatibility. The ratio of calcium and phosphorus in the coatings, as well as their phase composition, played a crucial role in determining the biological response of the coatings.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Arshad, Shafia Arshad, Muhammad K. Majeed, Johannes Frueh, Chun Chang, Ibtsam Bilal, Shah Iram Niaz, Muhammad Shahzeb Khan, Muhammad Adeel Tariq, Muhammad Yasir Mehboob
Summary: In this study, Ni and Zn-decorated Mg12O12 nanoclusters were used as efficient drug carriers for metformin. The decoration of Ni and Zn on the nanoclusters allowed for effective adsorption and detachment of the drug. The adsorption of metformin led to a reduction in the energy band gap and high charge transfer, making these systems promising for future drug carrier development.
Article
Engineering, Multidisciplinary
Anna I. Kozelskaya, Ksenia N. Verzunova, Igor O. Akimchenko, Johannes Frueh, Vsevolod I. Petrov, Galina B. Slepchenko, Olga V. Bakina, Marat I. Lerner, Leonid K. Brizhan, Denis V. Davydov, Artur A. Kerimov, Elena G. Cherempey, Sergey E. Krylov, Sven Rutkowski, Sergei I. Tverdokhlebov
Summary: A promising method for improving the functional properties of calcium-phosphate coatings is the incorporation of various antibacterial additives into their structure. This study investigated the fabrication and properties of zinc-containing calcium-phosphate coatings formed from three different electrolyte solutions. The results showed that coatings containing calcium acetate and zinc oxide had the highest zinc concentration and release, and exhibited the highest antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.
Article
Chemistry, Multidisciplinary
Muhammad Arshad, Shafia Arshad, Muhammad K. Majeed, Johannes Frueh, Chun Chang, Ibtsam Bilal, Shah Iram Niaz, Muhammad Shahzeb Khan, Muhammad Adeel Tariq, Muhammad Yasir Mehboob
Summary: Drug carriers have been effectively used in modern medication, and this study investigates the decoration of the Mg12O12 nanocluster with transition metals (Ni and Zn) for the adsorption of metformin (an anticancer drug). The results show that Ni and Zn decoration provides good attachment and detachment of the drug, with a reduction in the energy band gap and efficient charge transfer. The Ni and Zn-decorated Mg12O12 nanoclusters are recommended as efficient carriers for metformin, offering a novel direction for the future development of drug carriers.
Article
Materials Science, Multidisciplinary
Johannes Frueh, Sven Rutkowski, Tieyan Si, Meiyu Gai, Changyong Gao, Sergei Tverdokhlebov, Guangyu Qiu, Jean Schmitt, Qiang He, Yu-Xuan Ren, Jing Wang
Summary: This study presents a precise force measurement method and detailed analysis of the propulsion mechanisms of colloidal Janus micromotors. The findings reveal that thermophoretic and steam bubble forces are the key factors driving the propulsion of Janus micromotors, while the bubble force in the direction of light counteracts photophoretic force.
ADVANCED PHOTONICS RESEARCH
(2022)
Article
Engineering, Biomedical
Hongyue Zhang, Zesheng Li, Qiang He
Summary: Researchers have developed swimming hybrid cell-based robots composed of living cells to address the issue of immune clearance and fouling in synthetic swimming nanorobots. These swimming cellbots inherit biological functions from natural cells and can achieve various modes of locomotion through their synthetic parts. Dual-responsive neutrobots, as a representative example, have been utilized to cross the blood-brain barrier and target glioblastoma with high drug delivery efficiency. Swimming cellbots show potential in biomedical fields by loading different types of drugs and navigating through natural chemotaxis and external physical fields.
ADVANCED NANOBIOMED RESEARCH
(2022)
Article
Materials Science, Biomaterials
Hongyue Zhang, Liting Wang, Zesheng Li, Yuxing Ji, Zhiguang Wu, Qiang He
Summary: The toxicity effects of PTX-loaded magnetic neutrophil-hybrid swimming microrobots (neutrobots) were evaluated in mice after intravenous administration. Minimal immunotoxicity and liver and kidney toxicity were observed in mice 72 hours after receiving a dose of 3 x 10(6) PTX-loaded neutrobots. The low toxicity of drug-loaded neutrobots shows great promise for biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)