Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
出版年份 2016 全文链接
标题
Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
作者
关键词
-
出版物
Acta Crystallographica Section D-Structural Biology
Volume 72, Issue 5, Pages 682-693
出版商
International Union of Crystallography (IUCr)
发表日期
2016-04-26
DOI
10.1107/s2059798316004502
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
- (2015) Paul R. Gavine et al. BMC CANCER
- MEK inhibitors beyond monotherapy: current and future development
- (2015) Ian E Templeton et al. CURRENT OPINION IN PHARMACOLOGY
- The ins and outs of selective kinase inhibitor development
- (2015) Susanne Müller et al. Nature Chemical Biology
- Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors
- (2014) Seungil Han et al. BIOCHEMICAL JOURNAL
- ERK5/BMK1 Is Indispensable for Optimal Colony-Stimulating Factor 1 (CSF-1)-Induced Proliferation in Macrophages in a Src-Dependent Fashion
- (2014) E. Rovida et al. JOURNAL OF IMMUNOLOGY
- A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
- (2014) Apirat Chaikuad et al. Nature Chemical Biology
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones
- (2013) Xianming Deng et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor
- (2013) Jonathan M. Elkins et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
- (2013) Georgia Hatzivassiliou et al. NATURE
- Towards automated crystallographic structure refinement withphenix.refine
- (2012) Pavel V. Afonine et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2
- (2012) Mathew P. Martin et al. CHEMBIOCHEM
- Discovery of a Potential Allosteric Ligand Binding Site in CDK2
- (2011) Stephane Betzi et al. ACS Chemical Biology
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Presenting your structures: theCCP4mgmolecular-graphics software
- (2011) S. McNicholas et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Understanding the Impact of the P-loop Conformation on Kinase Selectivity
- (2011) Cristiano R. W. Guimarães et al. Journal of Chemical Information and Modeling
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein
- (2010) Qingkai Yang et al. CANCER CELL
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Expression of Erk5 in Early Stage Breast Cancer and Association with Disease Free Survival Identifies this Kinase as a Potential Therapeutic Target
- (2009) Juan Carlos Montero et al. PLoS One
- Identification of pharmacological inhibitors of the MEK5/ERK5 pathway
- (2008) Revati J. Tatake et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Non-redundant function of the MEK5–ERK5 pathway in thymocyte apoptosis
- (2008) Sue J Sohn et al. EMBO JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now