期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 2, 期 3, 页码 317-325出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00363
关键词
coordination bonding; pH-responsive; drug delivery; nanoparticles; cell imaging
资金
- National Natural Science Foundation of China [31371841]
Here, we reported a designable pH-responsive system on the basis of coordination bonded metal-tannic acid (TA) networks on zein/quaternized chitosan (HTCC) nanoparticles (NPs). Zein/HTCC NPs has been developed as a promising delivery system for natural bioactives in our lab previously. The coordination bonds between either the NH2-metal or the metal-TA are sensitive to pH variations that would release encapsulated drugs under designated pH conditions. Metal-TA film-coated zein/HTCC NPs had a spherical structure with particle size of 110-120 nm. Doxorubicin (DOX) was used as a model anticancer drug for release study and cell viability. The in vitro release profile of DOX loaded metal-TA films coated zein/HTCC NPs (DOX-zein/HTCC-TA/metal NPs) showed a significant pH-responsiveness when changing the amount or the type of metal ions. In in vitro cell assays, the blank zein/HTCC-TA/metal NPs showed low cytotoxicity, but the DOX-loaded NPs exhibited a high cytotoxic activity against HepG2. To impart enhanced imaging properties of metal-TA films, we used Eu-III to chelate with ligand named 2-thenoyltrifluoroacetone (TTA) to intense fluorescence intensities of Eu-III-TA films so as to develop pH-responsive zein/HTCC-TA/metal NPs for anticancer drug delivery as well as cell imaging.
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