Tiotropium in the add-on treatment of asthma in adults: clinical trial evidence and experience

Pharmacodynamics and Pharmacokinetics Following Once-Daily and Twice-Daily Dosing of Tiotropium Respimat®in Asthma Using Standardized Sample-Contamination Avoidance

(2016) Kai-Michael Beeh et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial

(2016) Eckard Hamelmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma

(2015) Michael E. Wechsler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cost-effectiveness of asthma therapy: a comprehensive review

(2015) Javier Domínguez-Ortega et al.   JOURNAL OF ASTHMA

The effect of fluticasone furoate/umeclidinium in adult patients with asthma: A randomized, dose-ranging study

(2015) Laurie A. Lee et al.   RESPIRATORY MEDICINE

A randomized, three-period crossover study of umeclidinium as monotherapy in adult patients with asthma

(2015) Laurie A. Lee et al.   RESPIRATORY MEDICINE

Once-daily tiotropium Respimat® 5 μg is an efficacious 24-h bronchodilator in adults with symptomatic asthma

(2015) Wolfgang Timmer et al.   RESPIRATORY MEDICINE

Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling

(2015) Loes E.M. Kistemaker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials

(2015) Huib A M Kerstjens et al.   Lancet Respiratory Medicine

Long-Term Once-Daily Tiotropium Respimat® Is Well Tolerated and Maintains Efficacy over 52 Weeks in Patients with Symptomatic Asthma in Japan: A Randomised, Placebo-Controlled Study

(2015) Ken Ohta et al.   PLoS One

Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data

(2014) Oznur Abadoglu et al.   Clinical Respiratory Journal

Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: A randomised dose-ranging study

(2014) Christian Vogelberg et al.   RESPIRATORY MEDICINE

Tiotropium Respimat® in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma

(2014) Kai-Michael Beeh et al.   RESPIRATORY RESEARCH

Predictors of response to tiotropium versus salmeterol in asthmatic adults

(2013) Stephen P. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treatment of Disorders Characterized by Reversible Airway Obstruction in Childhood: are Anti-cholinergic Agents the Answer?

(2012) Annabelle Quizon et al.   CURRENT PHARMACEUTICAL DESIGN

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

(2012) Huib A.M. Kerstjens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial

(2011) Huib A.M. Kerstjens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma

(2011) Eric D. Bateman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

(2010) Stephen P. Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Additive role of tiotropium in severe asthmatics and Arg16Gly inADRB2as a potential marker to predict response

(2009) H.-W. Park et al.   ALLERGY

Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype

(2008) H. Iwamoto et al.   EUROPEAN RESPIRATORY JOURNAL

Comparison of the Protective Effect Amongst Anticholinergic Drugs on Methacholine-Induced Bronchoconstriction in Asthma

(2008) Sposato Bruno et al.   JOURNAL OF ASTHMA