期刊
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
卷 9, 期 3, 页码 339-353出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1756283X16630718
关键词
enteric nervous system; gut-brain axis; interleukin 22; intestinal microbiota; serotonin; vagus nerve
资金
- Fondecyt [1130213, 1140776]
- PUCV-DI [037.470/2015, 037.386/2014]
The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.
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