Article
Multidisciplinary Sciences
Lewis A. Ingram, Vincent K. Carroll, Annie A. Butler, Matthew A. Brodie, Simon C. Gandevia, Stephen R. Lord
Summary: The study evaluated the validity of the upper limb Physiological Profile Assessment (PPA) in people with Parkinson's disease (PD) and found that the PPA can effectively differentiate PD patients from healthy controls and detect differences in upper limb test domains between different medication states. Six key tests, including handgrip strength, finger-press reaction time, 9-hole peg test, bimanual pole test, arm stability, and shirt buttoning, were identified for assessing upper limb function in PD patients. These findings suggest that clinical assessments in PD patients should prioritize tests of muscle strength, unilateral movement and dexterity, bimanual coordination, arm stability and functional tasks.
Article
Clinical Neurology
Jose A. Pineda-Pardo, Alvaro Sanchez-Ferro, Mariana H. G. Monje, Nicola Pavese, Jose A. Obeso
Summary: The striatal dopaminergic deficit in Parkinson's disease follows a somatotopically related pattern, with an upper-limb onset and progression to other regions of the striatum. The denervation of the putamen was confirmed in both hemispheres and corresponding hemibodies. The findings suggest a precise somatotopic onset of nigrostriatal denervation in Parkinson's disease.
Article
Biology
Song'an Shang, Daixin Li, Youyong Tian, Rushuai Li, Hongdong Zhao, Liyun Zheng, Yingdong Zhang, Yu-Chen Chen, Xindao Yin
Summary: The study found that early asymmetric disruptions in putaminal dopamine concentrations and nigrostriatal pathway microstructure were detected using hybrid PET-MRI in Parkinson's Disease (PD) patients. Associations between DTI metrics and motor performance on the more affected side were significantly mediated by putaminal SUVR. These findings suggest that molecular degeneration mediates the effects of microstructural disorganization on motor dysfunction in the early stages of PD.
COMMUNICATIONS BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinchong Shi, Yang Yang, Lulu Jiang, Jinhua Chen, Chang Yi, Ganhua Luo, Lei Wu, Jianmin Chu, Jian Wang, Ling Chen, Xiangsong Zhang
Summary: This study compared two imaging tracers, F-18-DOPA and F-18-DTBZ, for PET/CT imaging in idiopathic Parkinson disease (PD). The results showed that both tracers could reflect the same level of dopaminergic neuron degeneration in early stages of PD, and they had consistent visual analysis results.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Eva Schaeffer, Thomas Vaterrodt, Laura Zaunbrecher, Inga Liepelt-Scarfone, Kirsten Emmert, Benjamin Roeben, Morad Elshehabi, Clint Hansen, Sara Becker, Susanne Nussbaum, Jan-Hinrich Busch, Matthis Synofzik, Daniela Berg, Walter Maetzler
Summary: Our independent analysis of three PD cohorts consisting of a total of 1124 PD patients found that patients taking Levodopa CR reported a significantly higher burden of nocturnal akinesia. Higher Levodopa intake and MDS-UPDRS part IV scores predicted worse quality of sleep and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Arnaldo Fim Neto, Julia Baldi de Luccas, Bruno Leonardo Bianqueti, Luiz Ricardo da Silva, Tiago Paggi Almeida, Andre Kazuo Takahata, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo, Slawomir J. Nasuto, Maria Sheila Guimaraes Rocha, Diogo Coutinho Soriano, Fabio Godinho
Summary: This study investigated the dynamics of subthalamic nucleus local field potentials (STN-LFP) in Parkinson's disease patients and found differences in low-frequency beta bursts between tremor-dominant and postural instability and gait disorder phenotypes. These differences were correlated with motor symptoms.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Behnam Faraji, Korosh Rouhollahi, Akram Nezhadi, Zahra Jamalpoor
Summary: Deep brain stimulation (DBS) is an effective treatment for movement problems caused by various neurodegenerative diseases, such as Parkinson's disease. Recent studies have developed closed-loop DBS techniques to reduce hand tremors, particularly in Parkinson's patients. This study contributes by demonstrating the correlation between hand tremor and rigidity symptoms and proposing a non-integer proportional integral derivative (PID) control technique based on proximal policy optimization (PPO) to simultaneously reduce hand tremor and stiffness.
IEEE SENSORS JOURNAL
(2023)
Review
Health Care Sciences & Services
Camille Marques Alves, Andressa Rastrelo Rezende, Isabela Alves Marques, Luanne Cardoso Mendes, Angela Abreu Rosa de Sa, Marcus Fraga Vieira, Edgard Afonso Lamounier Junior, Adriano Alves Pereira, Fabio Henrique Monteiro Oliveira, Luciane Pascucci Sande de Souza, Guy Bourhis, Pierre Pino, Adriano de Oliveira Andrade, Yann Morere, Eduardo Lazaro Martins Naves
Summary: A scope review was conducted to compile the main methods used for assessing wrist rigidity in Parkinson's disease (PD) and to study their validity and reliability. Twenty-eight studies were included, which presented various quantitative assessment methods using instruments such as force and inertial sensors. These methods showed good correlation with clinical scales and were useful for detecting and monitoring rigidity. However, developing a standardized quantitative method for assessing rigidity in clinical practice remains a challenge.
Article
Neurosciences
Petrice M. Cogswell, Audrey P. Fan
Summary: Quantitative susceptibility mapping (QSM) is used to study susceptibility changes based on tissue composition and mineral deposition. Iron plays a significant role in magnetic susceptibility changes, especially in neurodegeneration and aging. The association of QSM with other imaging metrics such as positron emission tomography (PET) can provide insights into the pathophysiology of diseases and determine the diagnostic utility of QSM as an indicator of disease processes typically evaluated with PET.
Article
Biochemistry & Molecular Biology
Shir Hazut Krauthammer, Dan Cohen, Einat Even-Sapir, Hedva Lerman
Summary: The interpretation of F-18-DOPA PET/CT for assessing nigrostriatal dysfunction (NSD) is usually done visually based on basal ganglia (BG) uptake. In this study, the diagnostic performance of an automated method for BG uptake (AM-BG) and methods for pineal body uptake are evaluated to enhance the accuracy of visual assessment alone. Results show that VA-BG has the highest sensitivity and accuracy, and combining VA-BG with AM-BG does not improve diagnostic accuracy. However, combining VA-BG with pineal body uptake assessment can increase sensitivity but decrease specificity, reducing false negative reports. Further research is needed to validate this approach and study the relationship between pineal body uptake and NSD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Wen-biao Xian, Xin-chong Shi, Gan-hua Luo, Chang Yi, Xiang-song Zhang, Zhong Pei
Summary: The study demonstrated that co-registration analysis of F-18-flurodeoxyglucose and F-18-fluorodopa PET images can effectively differentiate between Parkinson's disease and multiple system atrophy parkinsonian subtype (MSA-P). Parkinson's disease patients showed hypermetabolism in the bilateral putamen, while MSA-P patients exhibited hypometabolism in this region.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Haim Golan, Olga Volkov, Eli Shalom
Summary: This review provides a comprehensive analysis of Parkinson's disease-related imaging techniques. While there is a wide range of imaging tools available for early diagnosis and treatment assessment of PD, there is still a need for further research in areas such as PD genetics, pathology, and early diagnosis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arnoldo Piccardo, Roberto Cappuccio, Gianluca Bottoni, Diego Cecchin, Luca Mazzella, Alessio Cirone, Sergio Righi, Martina Ugolini, Pietro Bianchi, Pietro Bertolaccini, Elena Lorenzini, Michela Massollo, Antonio Castaldi, Francesco Fiz, Laura Strada, Angelina Cistaro, Massimo Del Sette
Summary: The study evaluated the performance of a 3D convolutional neural network in analyzing [F-18]DOPA PET/CT to identify patients with nigro-striatal neurodegeneration. After training and testing on a group of patients, the 3D CNN showed high sensitivity and accuracy in diagnosing movement disorders.
EUROPEAN RADIOLOGY
(2021)
Review
Neurosciences
Shivam Kumar, Lav Goyal, Shamsher Singh
Summary: Parkinson's disease is a neurodegenerative movement disorder that affects a significant portion of the elderly population. The disease is characterized by the loss of certain neurons in the brain and can result in symptoms such as tremors and rigidity. Understanding the various factors contributing to the disease is crucial for accurate diagnosis and treatment.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Review
Clinical Neurology
Michiel F. Dirkx, Matteo Bologna
Summary: This article reviews the dysfunctional network underlying tremor in PD, discusses the oscillations and synchronization changes in two central motor circuits, and emphasizes the pathophysiological consequences of the abnormal interaction between the two systems.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Jan F. Meilof, Anouk van der Hoorn, Junqing Zhu, Chunying Wu, Yanming Wang, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Erik F. J. de Vries
Summary: This study aimed to evaluate [C-11]MeDAS as a PET tracer for myelin imaging in humans. The 2T3k model was found to be the optimal compartment model, and MLAIR2 was the best simplified method for quantification. [C-11]MeDAS PET can be used for quantification of myelin density in MS patients and is able to distinguish differences in myelin density within MS lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neuroimaging
Josje Brouwer, Saliha Ergezen, Maxim Johan Heymen Laurence Mulder, Geert J. Lycklama A. Nijeholt, Adriaan C. G. M. van Es, Aad van der Lugt, Diederik W. J. Dippel, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, J. M. Coutinho, Bart J. Emmer
Summary: This study aims to describe the clinical manifestations, outcomes, and safety of EVT in isolated PCA occlusions. The results indicate that EVT should be considered in selected patients with moderate-severe neurological deficits, as it is technically feasible and about half of the patients had good clinical outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Nerea Arrarte Terreros, Agnetha A. E. Bruggeman, Henk van Voorst, Praneeta R. Konduri, Ivo G. H. Jansen, Manon Kappelhof, Manon L. Tolhuisen, Nikki Boodt, Diederik W. J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, H. Bart van der Worp, Bart J. Emmer, Frederick J. A. Meijer, Yvo B. W. E. M. Roos, Ed van Bavel, Henk A. Marquering, Charles B. L. M. Majoie
Summary: There were no significant differences in EVT procedural and clinical outcomes between bifurcated and main stem thrombus patterns in MCA occlusion.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Simone M. Uniken Venema, Jan Willem Dankbaar, Lennard Wolff, Adriaan C. G. M. van Es, Marieke Sprengers, Aad van der Lugt, Diederik W. J. Dippel, H. Bart van der Worp
Summary: This study found that collateral status is not associated with the probability of successful recanalization after EVT and does not modify the association between successful recanalization and functional outcome.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Medicine, General & Internal
Wouter van der Steen, Rob A. van de Graaf, Vicky Chalos, Hester F. Lingsma, Pieter Jan van Doormaal, Jonathan M. Coutinho, Bart J. Emmer, Inger de Ridder, Wim van Zwam, H. Bart van der Worp, Irene van der Schaaf, Rob A. R. Gons, Lonneke S. F. Yo, Jelis Boiten, Ido van den Wijngaard, Jeannette Hofmeijer, Jasper Martens, Wouter Schonewille, Jan Albert Vos, Anil Man Tuladhar, Karlijn F. de Laat, Boudewijn van Hasselt, Michel Remmers, Douwe Vos, Anouk Rozeman, Otto Elgersma, Maarten Uyttenboogaart, Reinoud P. H. Bokkers, Julia van Tuijl, Issam Boukrab, Reneprime van den Berg, Ludo F. M. Beenen, Stefan D. Roosendaal, Alida Annechien Postma, Menno Krietemeijer, Geert Lycklama, Frederick J. A. Meijer, Sebastiaan Hammer, Anouk van der Hoorn, Albert J. Yoo, Dick Gerrits, Martine T. B. Truijman, Sanne Zinkstok, Peter J. Koudstaal, Sanne Manschot, Henk Kerkhoff, Daan Nieboer, Olvert Berkhemer, Lennard Wolff, P. Matthijs van der Sluijs, Henk van Voorst, Manon Tolhuisen, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Julie Staals, Robert J. van Oostenbrugge, Sjoerd F. M. Jenniskens, Lukas C. van Dijk, Heleen M. den Hertog, Adriaan C. G. M. van Es, Aad van der Lugt, Diederik W. J. Dippel, Bob Roozenbeek
Summary: This study aimed to evaluate the safety and efficacy of intravenous aspirin and unfractionated heparin during endovascular treatment, as well as their impact on functional outcomes in patients. The results showed that both medications were associated with an increased risk of symptomatic intracranial hemorrhage without any significant improvement in functional outcomes.
Article
Multidisciplinary Sciences
Bart R. J. van Dijken, Alfred O. Ankrah, Gilles N. Stormezand, Rudi A. J. O. Dierckx, Peter Jan van Laar, Anouk van der Hoorn
Summary: In this retrospective study, volume-based parameters MTV and TLMM were found to be inversely correlated with overall survival in IDH wild type glioblastoma patients, while SUV-based parameters did not show a correlation.
Review
Radiology, Nuclear Medicine & Medical Imaging
Linda bm Weerink, Auke pa Appelman, Reina w Kloet, A. N. O. U. K. van der Hoorn
Summary: To correctly identify intracranial hemorrhage (ICH) and distinguish it from other lesions, it is necessary to understand the imaging characteristics of ICH on susceptibility weighted imaging (SWI). It is a common misconception that blood appears as a black signal on SWI, but the appearance of ICH on SWI varies at different stages. Additionally, a low signal on SWI does not always indicate the presence of blood products. This review discusses and illustrates the appearance of ICH on SWI at all stages and common causes of a low signal on SWI.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Debora E. Peretti, David Vallez Garcia, Remco J. Renken, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx, Ronald Boellaard
Summary: This study compared the disease-specific patterns (AD-DP) based on regional cerebral blood flow (rCBF) and 2-deoxy-2-[F-18]fluoroglucose (FDG) PET for the identification of Alzheimer's disease (AD) patients. The results suggest that rCBF images may serve as an alternative to FDG PET scans for AD patient identification.
Review
Radiology, Nuclear Medicine & Medical Imaging
Elze R. R. Timmers, Marrit R. R. Klamer, Ramesh S. S. Marapin, Adriaan A. A. Lammertsma, Bauke M. M. de Jong, Rudi A. J. O. Dierckx, Marina A. J. Tijssen
Summary: This study provides a comprehensive literature overview on alterations in regional cerebral glucose metabolism in conditions associated with hyperkinetic movement disorders and ataxia, using [F-18]FDG PET. The study included studies on tremors, tics, dystonia, ataxia, chorea, myoclonus, functional movement disorders, or mixed movement disorders due to autoimmune or metabolic causes. The results showed that glucose metabolism changes were found in various brain regions in all movement disorders, and clinical characteristics often correlated with glucose metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Hajo Hund, Nikki Boodt, Daniel M. Hansen, Willem L. Haffmans, Geert J. Lycklama a Nijeholt, Jeannette E. Hofmeijer, Diederik W. J. R. Dippel, Aad van der Lugt, Adriaan C. G. M. van Es, Heleen M. M. A. van Beusekom
Summary: Thrombus composition is significantly associated with stroke etiology, with an increase in red blood cell (RBC) content and a decrease in fibrin/platelet (F/P) content raising the odds for a non-cardioembolic cause. No difference in thrombus composition was observed between cardioembolic thrombi and those of undetermined origin.
Review
Neuroimaging
Ramesh S. Marapin, Harm J. van der Horn, A. M. Madelein van der Stouwe, Jelle R. Dalenberg, Bauke M. de Jong, Marina A. J. Tijssen
Summary: This article provides a comprehensive review of resting-state brain connectivity alterations in patients with hyperkinetic movement disorders (HMD) using rs-fMRI. The study identifies various types of connectivity abnormalities in different HMD phenotypes and highlights the involvement of specific brain regions. The findings contribute to a better understanding of the neural connectivity profiles in HMD.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Wouter M. Sluis, Wouter H. Hinsenveld, Robert-Jan B. Goldhoorn, Lianne H. Potters, Agnetha A. E. Bruggeman, Anouk van der Hoorn, Joseph C. J. Bot, Robert J. van Oostenbrugge, Hester F. Lingsma, Jeannette Hofmeijer, Wim H. van Zwam, Charles Blm Majoie, H. Bart van der Worp
Summary: This study assessed the causes, timing, and risk factors of death after endovascular thrombectomy (EVT), finding that pneumonia and intracranial hemorrhage were the most common causes of death, and hyperglycemia, functional dependency before stroke, and severe neurological deficit at 24-48 hours after treatment were the strongest risk factors for death.
EUROPEAN STROKE JOURNAL
(2023)
Article
Neuroimaging
Giulia Carli, Sanne K. Meles, Fransje E. Reesink, Bauke M. de Jong, Andrea Pilotto, Alessandro Padovani, Andrea Galbiati, Luigi Ferini-Strambi, Klaus L. Leenders, Daniela Perani
Summary: This study compared the use of univariate Statistical Parametric Mapping (SPM) and multivariate Scaled Subprofile Model/Principal Component Analysis (SSM/PCA) for analyzing brain metabolism patterns in patients with a-synucleinopathies. The results showed that SPM's visual rating method had higher accuracy in identifying the brain metabolism characteristics of a-synucleinopathies.
NEUROIMAGE-CLINICAL
(2023)
Meeting Abstract
Endocrinology & Metabolism
C. Van Der Weijden, J. Meilof, R. Dierckx, A. van der Hoorn, A. Willemsen, A. Lammertsma, E. de Vries
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Oncology
Hiska L. van der Weide, Justyna Klos, Johannes A. Langendijk, Charlotte L. Brouwer, Peter F. Sinnige, Ronald J. H. Borra, Rudi A. J. O. Dierckx, Rients B. Huitema, Sandra E. Rakers, Anne M. Buunk, Jacoba M. Spikman, Ingeborg B. Bosma, Roelien H. Enting, Merethe Blandhol, Roland K. Chiu, Anouk van der Hoorn, Miranda C. A. Kramer
Summary: The study found that radiotherapy has varying effects on cognitive function and brain structure in patients with LGG, with left-sided tumor patients showing weaker language abilities while right-sided tumor patients' memory performance is affected.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
