期刊
NEUROIMAGE-CLINICAL
卷 12, 期 -, 页码 737-745出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2016.10.001
关键词
White matter; MRI; Brain; Hypertension; Blood pressure; Heritability
类别
资金
- National Institute on Aging [R01 AG018386, R01 AG022381, R01 AG022982, R01 AG018384, R03 AG 046413, K08 AG047903]
- National Institute on Alcohol Abuse and Alcoholism [R01AA021187]
- NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH062512] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG022982, R01AG018384, R01AG050595, K08AG047903, R01AG018386, R01AG022381, R03AG046413] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA021187] Funding Source: NIH RePORTER
White matter disease in the brain increases with age and cardiovascular disease, emerging in midlife, and these associations may be influenced by both genetic and environmental factors. We examined the frequency, distribution, and heritability of abnormal white matter and its association with hypertension in 395 middle-aged male twins (61.9 +/- 2.6 years) from the Vietnam Era Twin Study of Aging, 67% of whom were hypertensive. A multi-channel segmentation approach estimated abnormal regions within the white matter. Using multivariable regression models, we characterized the frequency distribution of abnormal white matter in midlife and investigated associations with hypertension and Apolipoprotein E-epsilon 4 status and the impact of duration and control of hypertension. Then, using the classical twin design, we estimated abnormal white matter heritability and the extent of shared genetic overlap with blood pressure. Abnormal white matter was predominantly located in periventricular and deep parietal and frontal regions; associated with age (t = 1.9, p = 0.05) and hypertension (t= 2.9, p = 0.004), but not Apolipoprotein epsilon 4 status; and was greater in those with uncontrolled hypertension relative to controlled (t= 3.0, p= 0.003) and normotensive (t = 4.0, p= 0.0001) groups, suggesting that abnormal white matter may reflect currently active cerebrovascular effects. Abnormal white matterwas highly heritable (a(2) = 0.81) and shared some genetic influences with systolic blood pressure (r(A) = 0.26), although there was evidence for distinct genetic contributions and unique environmental influences. Future longitudinal research will shed light on factors impacting white matter disease presentation, progression, and potential recovery. (C) 2016 The Authors. Published by Elsevier Inc.
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