期刊
NANOMATERIALS
卷 6, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nano6060100
关键词
superparamagnetic iron oxide nanoparticles; nanoparticle ligand functionalization; contrast agents; magnetic resonance imaging; cell internalization
类别
资金
- Natural Sciences and Engineering Research Council (Canada)
- Fonds de Recherche du Quebec Nature et technologies (FRQNT, Quebec, Canada)
- Center for Self-assembled Chemical Structures (FQRNT, Quebec, Canada)
Stable superparamagnetic iron oxide nanoparticles (SPIONs), which can be easily dispersed in an aqueous medium and exhibit high magnetic relaxivities, are ideal candidates for biomedical applications including contrast agents for magnetic resonance imaging. We describe a versatile methodology to render water dispersibility to SPIONs using tetraethylene glycol (TEG)-based phosphonate ligands, which are easily introduced onto SPIONs by either a ligand exchange process of surface-anchored oleic-acid (OA) molecules or via direct conjugation. Both protocols confer good colloidal stability to SPIONs at different NaCl concentrations. A detailed characterization of functionalized SPIONs suggests that the ligand exchange method leads to nanoparticles with better magnetic properties but higher toxicity and cell death, than the direct conjugation methodology.
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