Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Medicine, General & Internal
Christopher Byron, Christian R. Osadnik
Summary: People with hospitalised acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have low levels of physical activity and high risks of future exacerbations. This study evaluated the amount of physical activity accumulated during hospitalised AECOPDs and the effect on length of stay, physical activity recovery, and readmission risk. The findings suggest that sedentary behavior and light physical activity are the most promising metrics associated with clinically relevant outcomes following AECOPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yonghong Wu, Zhou Luo, Chuntao Liu
Summary: This study identified differences in fecal microbiome abundance and composition in AECOPD patients compared to stable COPD patients and normal subjects. The variations in fecal microbiota may be associated with the progression of COPD.
Article
Immunology
Xiaoyan Mao, Yao Li, Pengfei Shi, Ziwei Zhu, Juan Sun, Yu Xue, Zongren Wan, Dan Yang, Ting Ma, Jipeng Wang, Rong Zhu
Summary: This study analyzed the differences in sputum microbiota among COPD patients with different phenotypes during exacerbations. Significant microbial flora composition changes were observed between different phenotypes, and some key bacterial taxa were found to be correlated with clinical indicators.
MICROBIAL PATHOGENESIS
(2023)
Review
Medicine, General & Internal
Lorenzo Marinelli, Fabio Lanfranco, Giovanna Motta, Marco Zavattaro
Summary: Erectile dysfunction is a common issue in men with COPD, caused by various factors including hormonal imbalance, smoking, inflammation, endothelial dysfunction, chronic hypoxia, psychiatric disorders, and medications. This can significantly impact the quality of life for COPD patients, but healthcare providers often do not address sexual health concerns due to patients' reluctance to discuss intimate issues.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Respiratory System
Yan Li, Pingshu Zhang, Zhijie An, Chenyan Yue, Yamin Wang, Yunqiu Liu, Xiaodong Yuan, Ying Ma, Keli Li, Zundong Yin, Liye Wang, Huaqing Wang
Summary: This study aimed to evaluate the effectiveness of influenza and pneumococcal vaccines in patients with COPD. The results showed that both vaccines, when used separately or together, effectively reduced the risk of acute exacerbations, pneumonia, and hospitalizations in COPD patients, with the greatest effectiveness seen in preventing acute exacerbations.
Article
Biochemistry & Molecular Biology
Linfan Su, Yixian Qiao, Jinmei Luo, Rong Huang, Yi Xiao
Summary: Frequent acute exacerbations are the leading cause of high rates of hospitalization and mortality in chronic obstructive pulmonary disease (COPD). Reliable molecular markers for effective early diagnosis and prognosis of acute exacerbations are still lacking. In this study, we explored the interaction between host genetics and airway microbiome in the pathogenesis of frequent exacerbations. We identified candidate mutated genes and significant differences in bacterial diversity and composition between frequent-exacerbation phenotype (FE) and infrequent-exacerbation phenotype (IE) COPD patients. Our findings suggest that exomes and related microbiomes may serve as potential biomarkers for predicting frequent acute exacerbations in COPD patients.
Article
Critical Care Medicine
Surya P. Bhatt, Alvar Agusti, Mona Bafadhel, Stephanie A. Christenson, Jessica Bon, Gavin C. Donaldson, Don D. Sin, Jadwiga A. Wedzicha, Fernando J. Martinez
Summary: Chronic obstructive pulmonary disease is a major health problem with acute exacerbations that have limited improvements in outcomes. It is important to identify different etioendophenotypes to develop novel therapies.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Min Hyung Ryu, Jeong H. Yun, Jarrett D. Morrow, Aabida Saferali, Peter Castaldi, Robert Chase, Meryl Stav, Zhonghui Xu, Igor Barjaktarevic, MeiLan Han, Wassim Labaki, Yvonne J. Huang, Stephanie Christenson, Wanda O'Neal, Russell Bowler, Don D. Sin, Christine M. Freeman, Jeffrey L. Curtis, Craig P. Hersh
Summary: This study found a correlation between the transcriptome of circulating leukocytes and exacerbations of chronic obstructive pulmonary disease (COPD). Patients with decreased CD4 T cells in their blood were more susceptible to exacerbations. These findings provide new insights into the pathogenesis of COPD and potential strategies for its treatment and management.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Peter M. A. Calverley, Fernando J. Martinez, Jorgen Vestbo, Christine R. Jenkins, Robert Wise, David A. Lipson, Nicholas J. Cowans, Julie Yates, Courtney Crim, Bartolome R. Celli
Summary: Countries participating in COPD trials consistently differ in reporting exacerbations, which may explain why large studies are needed to show differences in exacerbation risk reduction between treatments.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Han Ni, Swe Zin Aye, Cho Naing
Summary: Magnesium sulfate may reduce hospital admissions, shorten hospital stays, and improve dyspnea scores in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, the evidence for other outcomes such as non-invasive ventilation, lung function, and blood gas measurements is inconclusive. Future large-scale studies are needed to further investigate the effects of magnesium sulfate.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Niamh Kelly, Lewis Winning, Christopher Irwin, Fionnuala T. Lundy, Dermot Linden, Lorcan McGarvey, Gerard J. Linden, Ikhlas A. El Karim
Summary: This systematic review explores the association between poor periodontal health and frequency of COPD exacerbations. Research suggests that periodontal treatment can reduce exacerbation frequency in COPD patients, leading to improved quality of life.
Article
Health Care Sciences & Services
Siyang Zeng, Mehrdad Arjomandi, Yao Tong, Zachary C. Liao, Gang Luo
Summary: This study developed a more accurate model to predict severe COPD exacerbations. The model showed high accuracy and can help identify high-risk COPD patients for preventive care management, thereby improving outcomes.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Clinical Neurology
Juan Huang, Yongjun Bian, Yuanchen Zhao, Zaiyan Jin, Li Liu, Guangxi Li
Summary: Anxiety and/or depression in stable COPD patients are significantly associated with a higher risk of acute exacerbation. Mental health care should be paid more attention to decrease the risk of acute exacerbation in COPD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Elisabetta Zinellu, Angelo Zinellu, Alessandro G. Fois, Maria Carmina Pau, Valentina Scano, Barbara Piras, Ciriaco Carru, Pietro Pirina
Summary: Studies show an imbalance between oxidant and antioxidant molecules favoring the former in exacerbations of COPD, suggesting the potential usefulness of targeting oxidative stress in monitoring disease progression, particularly in patients more prone to exacerbations. Additional research with standardized methods in well-characterized populations is needed.
Article
Pediatrics
Irene Braithwaite, Alistair W. Stewart, Robert J. Hancox, Richard Beasley, Rinki Murphy, Edwin A. Mitchell
Article
Respiratory System
Robert J. Hancox, Hayden H. Shin, Andrew R. Gray, Richie Poulton, Malcolm R. Sears
EUROPEAN RESPIRATORY JOURNAL
(2015)
Article
Endocrinology & Metabolism
Rinki Murphy, Alistair W. Stewart, Irene Braithwaite, Richard Beasley, Robert J. Hancox, Edwin A. Mitchell
Article
Cardiac & Cardiovascular Systems
Robert J. Hancox, Andrew R. Gray, Malcolm R. Sears, Richie Poulton
RESPIRATORY MEDICINE
(2016)
Article
Nutrition & Dietetics
Clare R. Wall, Alistair W. Stewart, Robert J. Hancox, Rinki Murphy, Irene Braithwaite, Richard Beasley, Edwin A. Mitchell
Article
Medicine, General & Internal
Paul M. Kelly, Tom Kotsimbos, Anna Reynolds, Richard Wood-Baker, Bob Hancox, Simon G. A. Brown, Mark Holmes, Graham Simpson, Simon Bowler, Grant Waterer, Louis B. Irving, Christine Jenkins, Phillip J. Thompson, Allen C. Cheng
MEDICAL JOURNAL OF AUSTRALIA
(2011)
Article
Pediatrics
R. J. Hancox, A. W. Stewart, I. Braithwaite, R. Beasley, R. Murphy, E. A. Mitchell