期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 39, 期 10, 页码 1095-1103出版社
SPRINGER
DOI: 10.1007/s40618-016-0473-1
关键词
Epigenetics; DNA methylation; Type 2 diabetes; Obesity
资金
- European Foundation for the Study of Diabetes (EFSD)
- Ministero dell'Universita e della Ricerca Scientifica [PON 01_02460]
- Ministero dell'Universita e della Ricerca Scientifica (grant PRIN)
- Ministero dell'Universita e della Ricerca Scientifica (grant FIRB-MERIT)
- Societa Italiana di Diabetologia (SID-FO.DI.RI)
- P.O.R. Campania FSE, Project CREMe
Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.
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